Single prolonged stress induces behavior and transcriptomic changes in the medial prefrontal cortex to increase susceptibility to anxiety-like behavior in rats DOI Creative Commons
Javed Iqbal,

Geng-Di Huang,

Dan Shen

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 19, 2024

Transcriptomic studies offer valuable insights into the pathophysiology of traumatic stress-induced neuropsychiatric disorders, including generalized anxiety disorder and post-traumatic stress (PTSD). The medial prefrontal cortex (mPFC) has been implicated in emotion, cognitive function, psychiatric disorders. Alterations function mPFC have observed PTSD patients. However, specific transcriptomic mechanisms governed by genes within under remain elusive.

Language: Английский

Novel insight into astrocyte-mediated gliotransmission modulates the synaptic plasticity in major depressive disorder DOI
Lan Lei, Yufei Wang,

Cong-Ya Chen

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 355, P. 122988 - 122988

Published: Aug. 15, 2024

Language: Английский

Citations

9
Causal relationship between gut microbiota, lipids, and neuropsychiatric disorders: A Mendelian randomization mediation study DOI
Nan Zhang, Xiaoyu Dong

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Neurexin 3 is differentially methylated and downregulated following chronic ethanol use. DOI Creative Commons
Clara C. Lowe,

Frances Miller,

Dongqin Zhu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Abstract Background: Increasing evidence confirms the value of unbiased epigenomic and transcriptomic profiling in identification neuroadaptations alcohol use disorder (AUD). Through this integrated omics analysis, we identified neurexin3 (NRXN3) as a critical player mediating alcohol’s effects on cortex primates mice. Neurexins are presynaptic cell adhesion molecules synaptic adaptations. Although has been linked to substance disorders, specific regulatory mechanisms that enable NRXN3’s transcript/isoform diversity downstream dynamics contributing AUD remain unknown. Methods: We conducted genome-wide DNA methylation (DNAm) RNAseq analyses dorsolateral prefrontal (dlPFC) rhesus macaques remained alcohol-naïve (controls) or self-administered ethanol for 12 months. qPCR immunohistochemistry were used measure levels Nrxn3 transcripts isoforms parvalbumin interneurons prelimbic (PLC) mice following chronic exposure. Results: Our sex-specific differences DNAm gene expression. However, there was shared enrichment signaling pathways neurotransmission plasticity. Specifically, found differential mapping NRXN3, downregulation transcript NRXN3b. further showed conserved use, occurred PLC. Conclusions: research provides significant insights into complex by which affects expression NRXN3within PFC/PLC how might be modulating plasticity type manner.

Language: Английский

Citations

0
Single prolonged stress induces behavior and transcriptomic changes in the medial prefrontal cortex to increase susceptibility to anxiety-like behavior in rats DOI Creative Commons
Javed Iqbal,

Geng-Di Huang,

Dan Shen

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 19, 2024

Transcriptomic studies offer valuable insights into the pathophysiology of traumatic stress-induced neuropsychiatric disorders, including generalized anxiety disorder and post-traumatic stress (PTSD). The medial prefrontal cortex (mPFC) has been implicated in emotion, cognitive function, psychiatric disorders. Alterations function mPFC have observed PTSD patients. However, specific transcriptomic mechanisms governed by genes within under remain elusive.

Language: Английский

Citations

0