Diabetes mellitus and glaucoma DOI
Parveen Rewri

Published: May 1, 2024

Diabetes mellitus (DM) and glaucoma are two chronic disorders that independently affect the eye potential causes of vision impairment blindness. DM, being a micro-vasculopathy metabolic condition, affects functioning cells, including retinal ganglion cells (RGC). The association between epidemiology primary open-angle is not well understood. relationship DM secondary thoroughly investigated. Neovascular an important complication diabetic retinopathy, especially with proliferative type. also seems to influence biomechanical properties cornea, measurement intraocular pressure (IOP). Clinical control has been related progression surgical outcomes glaucoma. IOP lowering drugs blood glucose level; conversely, oral hypoglycemic agents insulin IOP.

Language: Английский

The role of neurotrophic factors in retinal ganglion cell resiliency DOI Creative Commons

Anina Abraham,

Michael Telias

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Jan. 29, 2025

Many retinal diseases are characterized by direct or indirect ganglion cell (RGC) neurodegeneration. In glaucoma and optic nerve neuropathies, RGCs the primary affected cells, whereas in photoreceptor dystrophies, RGC loss is secondary to death of rods cones. The either case will irreversibly cause vision, as sole output neurons retina. neurodegeneration affects certain preferentially, resulting subpopulations resilient susceptible cells. Neurotrophins (NTs) known mediate neuronal survival through downstream activation various anti-apoptotic pathways. this review, we summarize current methods identification quantification animal models neurodegeneration, describe advantages disadvantages associated with these techniques. Using techniques, multiple studies have uncovered potential role NTs protecting during BDNF NGF delivery promoting experimental glaucoma. fewer addressed similar questions where degeneration, yielding conflicting results. Our analysis suggests that seemingly contradictory results can be explained varying onset geographic distribution death.

Language: Английский

Citations

0
A Neuroprotective Peptide Modulates Retinal cAMP Response Element-Binding Protein (CREB), Synapsin I (SYN1), and Growth-Associated Protein 43 (GAP43) in Rats with Silicone Oil-Induced Ocular Hypertension DOI Creative Commons
Gretchen A. Johnson,

Raghu R. Krishnamoorthy,

Ram H. Nagaraj

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 219 - 219

Published: Feb. 3, 2025

This study evaluated the neuroprotective potential of peptain-1 conjugated to a cell-penetrating peptide (CPP-P1) in an ocular hypertension model glaucoma. Brown Norway (BN) rats were subjected intraocular pressure (IOP) elevation via intracameral injection silicone oil (SO), with concurrent intravitreal injections either CPP-P1 or vehicle. Retinal cross-sections analyzed for markers neuroprotection, including cAMP response element-binding protein (CREB), phosphorylated CREB (p-CREB), growth-associated protein-43 (GAP43), synapsin-1 (SYN1), and superoxide dismutase 2 (SOD2). Hematoxylin eosin staining was used assess retinal-layer thickness. SO-treated exhibited significant reductions thickness inner nuclear layer (INL, 41%, p = 0.016), plexiform (IPL, 52%, 0.0002), ganglion cell (GCL, 57%, 0.001). treatment mitigated these reductions, preserving INL by 32% (p 0.059), IPL 19% 0.119), GCL 31% 0.057). Increased levels 0.17) p-CREB 0.04) observed IOP-elevated, CPP-P1-treated retinas compared vehicle-treated retinas. Although overall GAP43 low, there modest increase expression within SO- 0.15 0.09, respectively) SO reduced SYN1 both 0.01), whereas significantly increased 0.03) 0.002). While SOD2 minimal across all groups, trend toward animals 0.16). The replicated removal after 7 days monitored 21 followed retinal flat-mount preparation (RGC) survival. A 42% loss RGCs 0.009) SO-injected eyes, which approximately 37% treatment. These findings suggest that is promising agent promotes survival preservation other neurons, potentially through enhanced signaling rat SO-induced hypertension.

Language: Английский

Citations

0
Systemically administered mini α-crystallin peptide delays cataract progression in streptozotocin-induced diabetic rats DOI

Pandarinath Savitikadi,

Lucky Dash,

Kiran Kumar Angadi

et al.

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2025, Volume and Issue: unknown, P. 130814 - 130814

Published: April 1, 2025

Language: Английский

Citations

0
Diabetes mellitus and glaucoma DOI
Parveen Rewri

Published: May 1, 2024

Diabetes mellitus (DM) and glaucoma are two chronic disorders that independently affect the eye potential causes of vision impairment blindness. DM, being a micro-vasculopathy metabolic condition, affects functioning cells, including retinal ganglion cells (RGC). The association between epidemiology primary open-angle is not well understood. relationship DM secondary thoroughly investigated. Neovascular an important complication diabetic retinopathy, especially with proliferative type. also seems to influence biomechanical properties cornea, measurement intraocular pressure (IOP). Clinical control has been related progression surgical outcomes glaucoma. IOP lowering drugs blood glucose level; conversely, oral hypoglycemic agents insulin IOP.

Language: Английский

Citations

0