Effects of SARS-CoV-2 Spike S1 Subunit on the Interplay Between Hepatitis B and Hepatocellular Carcinoma Related Molecular Processes in Human Liver DOI Creative Commons
Giovanni Colonna

Livers, Journal Year: 2024, Volume and Issue: 5(1), P. 1 - 1

Published: Dec. 31, 2024

Background: This study addresses a particular aspect of the biological behavior Spike subunit S1 SARS-CoV-2. Researchers observed acting freely in human organism during and after COVID-19 vaccination. One its properties is that it interacts one-to-one with proteins. 12 specific proteins liver. Methods: We used these as seeds to extract their functional relationships from proteome through enrichment. The interactome representing set metabolic activities which they are involved shows several molecular processes (KEGG), including some linked HBV (hepatitis B) HCC (hepatocellular carcinoma) many genes/proteins involved. Reports show that, COVID patients, reactivated or progressed cancer. Results: analyzed approaches understand whether two pathologies have independent progressions common progression. All our efforts consistently showed involving both significantly present all we used, making difficult any useful information about fate. Through BioGRID, extracted experimental data vivo but derived model cell systems. lack patient STRING results prevents diagnosis prediction real disease progression; therefore, can consider them “aseptic” data. Conclusion: tells us genes HVB-related pathways potential activate processes. gold standard. It comparison similar interactions found individual phenotypes phenotype favors hinders also suggests how use features. These sets constitute “toolkit”. In fact, if compare patient, will provide on level phenotypic state driving disease. composition an entire group broader more detailed than single marker. Therefore, protein compositions serve reference system doctors cases for personalized medicine diagnoses.

Language: Английский

A Dual‐Targeting Biomimetic Nanoplatform Integrates SDT/CDT/Gas Therapy to Boost Synergistic Ferroptosis for Orthotopic Hepatocellular Carcinoma Therapy DOI Creative Commons
Wen Meng, Ting Chen, Xueping Li

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract The development of efficient therapeutic strategies to promote ferroptotic cell death offers significant potential for hepatocellular carcinoma (HCC) treatment. Herein, this study presents an HCC‐targeted nanoplatform that integrates bimetallic FeMoO 4 nanoparticles with CO‐releasing molecules, and further camouflaged SP94 peptide‐modified macrophage membrane enhanced ferroptosis‐driven multi‐modal therapy HCC. Leveraging the multi‐enzyme activities multivalent metallic elements, not only decomposes H 2 O generate oxygen alleviate tumor hypoxia but also depletes glutathione inactivate peroxides 4, which amplify sonodynamic under ultrasound (US) irradiation. Meanwhile, catalyzes Fenton reaction produce hydroxyl radicals chemodynamic therapy. Elevated intracellular reactive species trigger cascade release CO, leading lethal lipid peroxidation enhancing ferroptosis‐mediated This demonstrates robust anti‐tumor efficacy US irradiation favorable biosafety in both subcutaneous orthotopic HCC models, representing a promising approach Additionally, findings offer new insights into microenvironment modulation optimize US‐triggered cancer

Language: Английский

Citations

0
Mitochondrial alterations and signatures in hepatocellular carcinoma DOI Creative Commons
Tsung‐Hsien Chen, Shu-Hsien Lin, Ming‐Yang Lee

et al.

Cancer and Metastasis Reviews, Journal Year: 2025, Volume and Issue: 44(1)

Published: Feb. 18, 2025

Language: Английский

Citations

0
Overexpression and clinicopathological significance of zinc finger protein 71 in hepatocellular carcinoma DOI

Kai Qin,

Dandan Xiong,

Zhen Qin

et al.

World Journal of Hepatology, Journal Year: 2025, Volume and Issue: 17(2)

Published: Feb. 20, 2025

BACKGROUND Hepatocellular carcinoma (HCC) is one of the most prevalent and aggressive forms liver cancer, with high morbidity poor prognosis due to late diagnosis limited treatment options. Despite advances in understanding its molecular mechanisms, effective biomarkers for early detection targeted therapy remain scarce. Zinc finger protein 71 (ZNF71), a zinc-finger protein, has been implicated various cancers, yet role HCC remains largely unexplored. This gap knowledge underscores need further investigation into ZNF71 potential as diagnostic or therapeutic target HCC. AIM To explore expression levels, clinical relevance, mechanisms progression METHODS The study evaluated 235 specimens 13 noncancerous tissue samples using immunohistochemistry. High-throughput datasets were employed assess differential association pathological features. impact on cell line growth was examined through clustered regularly interspaced short palindromic repeat knockout screens. Co-expressed genes identified analyzed enrichment LinkedOmics Sangerbox 3.0, focusing significant correlations (P < 0.01, correlation coefficient ≥ 0.3). Furthermore, relationship between immune infiltration quantified TIMER2.0. RESULTS showed higher tissues vs non-tumorous tissues, statistical difference 0.05). Data from UALCAN platform indicated increased levels across mid-stage HCC, correlating disease severity analysis presented standardized mean 0.55 (95% confidence interval [CI]: 0.34-0.75). efficiency mRNA evaluated, yielding an area under curve 0.78 (95%CI: 0.75-0.82), sensitivity 0.63 0.53-0.72), specificity 0.82 0.73-0.89). Diagnostic likelihood ratios positive at 3.61 2.41-5.41) negative 0.45 0.36-0.56). strong such ZNF470, ZNF256, ZNF285. Pathway analyses highlighted associations herpes simplex virus type 1 infection, cycle, DNA replication. Negative involved metabolic pathways, peroxisomes, fatty acid degradation. TIMER2.0 demonstrated types, including CD4+ T cells, B regulatory monocytes, macrophages, myeloid dendritic cells. CONCLUSION significantly upregulated disease’s stages. It appears promote involving cycle metabolism associated infiltration. These findings suggest that could be novel diagnosing treating

Language: Английский

Citations

0
Triggering Pyroptosis in Cancer DOI Creative Commons

Daniel E. Johnson,

Zhibin Cui

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 348 - 348

Published: Feb. 28, 2025

Pyroptosis is an inflammatory programmed cell death recently identified as a crucial cellular process in various diseases, including cancers. Unlike other forms of death, canonical pyroptosis involves the specific cleavage gasdermin by caspase-1, resulting membrane damage and release pro-inflammatory cytokines IL-1β IL-18. Initially observed innate immune cells responding to external pathogens or internal signals, pyroptotic has now been numerous types. Recent studies have extensively explored different ways trigger solid tumors, presenting promising avenue for cancer treatment. This review outlines mechanisms both noncanonical pertinent primarily focuses on biomolecules that can induce malignancies. strategy aims not only eliminate but also promote improved tumor microenvironment. Furthermore, emerging research indicates targeting pathways may improve effectiveness existing treatments, making them more potent against resistant types, offering new hope overcoming treatment resistance aggressive

Language: Английский

Citations

0
Machine learning analysis identified NNMT as a potential therapeutic target for hepatocellular carcinoma based on PCD-related genes DOI Creative Commons

Fuqun Wei,

P.C. Huang, Bing Zhang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 3, 2025

Language: Английский

Citations

0
Inflammation and cancer: molecular mechanisms and clinical consequences DOI Creative Commons
Hikmet Akkız, Cem Şimşek, Deniz Balcı

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 17, 2025

Inflammation, a hallmark of cancer, has been associated with tumor progression, transition into malignant phenotype and efficacy anticancer treatments in cancer. It affects all stages from the initiation carcinogenesis to metastasis. Chronic inflammation induces immunosup-pression, providing an environment conducive carcinogenesis, whereas acute antitumor immune response, leading suppression. Solid tumors have inflammatory microenvironment (TME) containing cancer cells, stromal soluble molecules, which plays key role progression therapy response. Both cells TME are highly plastic constantly change their phenotypic functional properties. Cancer-associated inflammation, majority consists innate important cell plasticity, development drug resistance. Today, combined used advanced technologies, such as single-cell RNA sequencing spatial molecular imaging analysis, pathways linking chronic largely elucidated. In this review article, we highlighted cellular mechanisms involved cancer-associated its effects on treatment We also comprehensively setting GI cancers.

Language: Английский

Citations

0
Mixed lineage kinase domain-like protein in liver diseases: Cell-type-specific functions and dual roles DOI
Ming‐Xing Liang, Ying Zhou, Shuren Li

et al.

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(14)

Published: April 9, 2025

In this letter, we comment on the article by Xuan Yuan et al, published in recent issue of World Journal Gastroenterology. Mixed lineage kinase domain-like protein (MLKL) exhibits cell-type-specific functions liver parenchymal and non-parenchymal cells, playing dual roles pathogenesis diseases. hepatocytes, MLKL primarily mediates necroptosis inhibits autophagy, thereby exacerbating injury. Conversely, modulates inflammatory responses promotes fibrotic processes, driving disease progression. Notably, also demonstrates protective under specific conditions. For instance, can inhibit intracellular bacterial replication, promote endosomal trafficking, facilitate generation release extracellular vesicles, potentially exerting hepatoprotective effects. Understanding these mechanisms action, including its promoting injury providing protection, is crucial for elucidating complex diseases developing targeted therapeutic strategies.

Language: Английский

Citations

0
Analysis and identification of PTBP2 as an oncogene in hepatocellular carcinoma DOI Creative Commons
Yuxuan Li,

Fengguang Zhai,

Lili Kong

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 12, 2025

Language: Английский

Citations

0
Effects of SARS-CoV-2 Spike S1 Subunit on the Interplay Between Hepatitis B and Hepatocellular Carcinoma Related Molecular Processes in Human Liver DOI Creative Commons
Giovanni Colonna

Livers, Journal Year: 2024, Volume and Issue: 5(1), P. 1 - 1

Published: Dec. 31, 2024

Background: This study addresses a particular aspect of the biological behavior Spike subunit S1 SARS-CoV-2. Researchers observed acting freely in human organism during and after COVID-19 vaccination. One its properties is that it interacts one-to-one with proteins. 12 specific proteins liver. Methods: We used these as seeds to extract their functional relationships from proteome through enrichment. The interactome representing set metabolic activities which they are involved shows several molecular processes (KEGG), including some linked HBV (hepatitis B) HCC (hepatocellular carcinoma) many genes/proteins involved. Reports show that, COVID patients, reactivated or progressed cancer. Results: analyzed approaches understand whether two pathologies have independent progressions common progression. All our efforts consistently showed involving both significantly present all we used, making difficult any useful information about fate. Through BioGRID, extracted experimental data vivo but derived model cell systems. lack patient STRING results prevents diagnosis prediction real disease progression; therefore, can consider them “aseptic” data. Conclusion: tells us genes HVB-related pathways potential activate processes. gold standard. It comparison similar interactions found individual phenotypes phenotype favors hinders also suggests how use features. These sets constitute “toolkit”. In fact, if compare patient, will provide on level phenotypic state driving disease. composition an entire group broader more detailed than single marker. Therefore, protein compositions serve reference system doctors cases for personalized medicine diagnoses.

Language: Английский

Citations

0