The Role of Immune Cells in the Progression of Idiopathic Pulmonary Fibrosis DOI
Xin Wang

Highlights in Science Engineering and Technology, Journal Year: 2025, Volume and Issue: 139, P. 63 - 70

Published: April 28, 2025

Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease of unknown etiology, characterized by the excessive deposition fibrotic tissue in lungs. The global incidence IPF on rise, and associated with poor prognosis high mortality rate, median survival time only 2 to 5 years after diagnosis. Pathologically, most commonly classified into two subtypes: Usual Interstitial Pneumonia (UIP) Non-Specific (NSIP). Current research suggests that injury alveolar epithelial cells plays pivotal role initiation IPF. Damaged secrete variety cytokines chemokines, which recruit immune cells, including macrophages, T B neutrophils, tissue. These contribute local dysregulation, leading further irreversible activation myofibroblasts, turn accelerates progression fibrosis. This review focuses roles different cell populations pathogenesis idiopathic pulmonary

Language: Английский

Translational Regulators in Pulmonary Fibrosis: MicroRNAs, Long Non-Coding RNAs, and Transcript Modifications DOI Creative Commons
Sandra Gill, Richard H. Gomer

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 536 - 536

Published: April 3, 2025

Fibrosing disorders including idiopathic pulmonary fibrosis (IPF) are progressive irreversible diseases, often with poor prognoses, characterized by the accumulation of excessive scar tissue and extracellular matrix. Translational regulation has emerged as a critical aspect gene expression control, dysregulation key effectors is associated disease pathogenesis. This review examines current literature on translational regulators in IPF, focusing microRNAs (miRNAs), long non-coding RNAs (lncRNAs), RNA transcript modifications alternative polyadenylation chemical modification. Some these potentiate fibrosis, some inhibit fibrosis. In profibrotic upregulated, antifibrotic downregulated. Correcting defects IPF-associated could be an intriguing avenue for therapeutics.

Language: Английский

Citations

0
The Role of Immune Cells in the Progression of Idiopathic Pulmonary Fibrosis DOI
Xin Wang

Highlights in Science Engineering and Technology, Journal Year: 2025, Volume and Issue: 139, P. 63 - 70

Published: April 28, 2025

Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease of unknown etiology, characterized by the excessive deposition fibrotic tissue in lungs. The global incidence IPF on rise, and associated with poor prognosis high mortality rate, median survival time only 2 to 5 years after diagnosis. Pathologically, most commonly classified into two subtypes: Usual Interstitial Pneumonia (UIP) Non-Specific (NSIP). Current research suggests that injury alveolar epithelial cells plays pivotal role initiation IPF. Damaged secrete variety cytokines chemokines, which recruit immune cells, including macrophages, T B neutrophils, tissue. These contribute local dysregulation, leading further irreversible activation myofibroblasts, turn accelerates progression fibrosis. This review focuses roles different cell populations pathogenesis idiopathic pulmonary

Language: Английский

Citations

0