Lipid Metabolism and Immune Response in Hepatocellular Carcinoma: Interplay Driving Tumor Progression DOI Creative Commons
Tiffany Ching-Yun Yu, Yu‐Man Tsui, Xin Zhang

et al.

Published: April 4, 2025

With the rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD), it has become a significant risk factor for hepatocellular carcinoma (HCC). This review focuses on roles lipid metabolism aberrations and reprogramming in HCC development. We begin with brief overview relevant lipids to HCC, including fatty acyls, glycerolipids, glycerophospholipids sterol lipids, discuss particularly how associated its promotes chemoresistance HCC. then explore heterogeneity distribution across different stages includes intra-tissue spatial histological structure zonated regions liver, interpatient tumor at various degrees resolutions, from single cell bulk tissue levels. Next, we describe plasticity MASLD advent immunotherapy also examine relationship between anti-tumor immunity Finally, address challenges future perspectives targeting as dual approach improve treatment.

Language: Английский

Metabolic Reprogramming of Tumor Microenviroment by Engineered Bacteria DOI
Heng Wang, Fang Xu, Chao Wang

et al.

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Lipid Metabolism and Immune Response in Hepatocellular Carcinoma: Interplay Driving Tumor Progression DOI Creative Commons
Tiffany Ching-Yun Yu, Yu‐Man Tsui, Xin Zhang

et al.

Published: April 4, 2025

With the rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD), it has become a significant risk factor for hepatocellular carcinoma (HCC). This review focuses on roles lipid metabolism aberrations and reprogramming in HCC development. We begin with brief overview relevant lipids to HCC, including fatty acyls, glycerolipids, glycerophospholipids sterol lipids, discuss particularly how associated its promotes chemoresistance HCC. then explore heterogeneity distribution across different stages includes intra-tissue spatial histological structure zonated regions liver, interpatient tumor at various degrees resolutions, from single cell bulk tissue levels. Next, we describe plasticity MASLD advent immunotherapy also examine relationship between anti-tumor immunity Finally, address challenges future perspectives targeting as dual approach improve treatment.

Language: Английский

Citations

0