Impact of moderate environmental heat stress during running exercise on circulating markers of gastrointestinal integrity in endurance athletes DOI Creative Commons
Thomas Beiter, Gunnar Erz,

Anna Würden

et al.

Physiological Reports, Journal Year: 2025, Volume and Issue: 13(7)

Published: April 1, 2025

In the present study, we aimed to determine effect of moderate ambient heat stress on exercise-provoked patterns "leaky gut" biomarkers and markers in well-trained athletes. Eleven triathletes performed a strenuous 1-h treadmill run, both under normal conditions (N, 18-21°C) as well environmental (H, 28-30°C). Core body temperature (Tc), heart rate (HR), rating perceived exertion (RPE) significantly increased conditions, with higher values during after H run. We observed significant main acute exercise circulating leukocyte numbers, release cell-free human DNA (cfDNA) but not bacterial (bacDNA), plasma levels intestinal fatty-acid binding protein (I-FABP), lipopolysaccharide-binding (LBP), endotoxin (LPS), D-lactate. Exercising accelerated mobilization neutrophils lymphocytes, affected cfDNA, D-lactate, I-FABP, creatinine, blood potassium levels. Multiple correlation analysis revealed association between Tc, max cfDNA (r = 0.583, p 0.012) I-FABP 0.554, 0.026). Our data indicate that exercising may only affect paracellular also transcellular permeability.

Language: Английский

Impact of moderate environmental heat stress during running exercise on circulating markers of gastrointestinal integrity in endurance athletes DOI Creative Commons
Thomas Beiter, Gunnar Erz,

Anna Würden

et al.

Physiological Reports, Journal Year: 2025, Volume and Issue: 13(7)

Published: April 1, 2025

In the present study, we aimed to determine effect of moderate ambient heat stress on exercise-provoked patterns "leaky gut" biomarkers and markers in well-trained athletes. Eleven triathletes performed a strenuous 1-h treadmill run, both under normal conditions (N, 18-21°C) as well environmental (H, 28-30°C). Core body temperature (Tc), heart rate (HR), rating perceived exertion (RPE) significantly increased conditions, with higher values during after H run. We observed significant main acute exercise circulating leukocyte numbers, release cell-free human DNA (cfDNA) but not bacterial (bacDNA), plasma levels intestinal fatty-acid binding protein (I-FABP), lipopolysaccharide-binding (LBP), endotoxin (LPS), D-lactate. Exercising accelerated mobilization neutrophils lymphocytes, affected cfDNA, D-lactate, I-FABP, creatinine, blood potassium levels. Multiple correlation analysis revealed association between Tc, max cfDNA (r = 0.583, p 0.012) I-FABP 0.554, 0.026). Our data indicate that exercising may only affect paracellular also transcellular permeability.

Language: Английский

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