HYPERGRAVITY INFLUENCES MOUSE ERYTHROCYTE MEMBRANE LIPID COMPOSITION AND ANTIOXIDANT POTENTIAL

Acta Astronautica, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Integrative in silico and in vitro analysis of Pinus roxburghii essential oil: unveiling its antioxidant, antidiabetic, and antiglycation potential

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 29, 2025

Essential Oils (EOs) are a rich source of secondary metabolites that exhibit various biological activities. This study includes GCMS analysis Pinus roxburghii EO, computational investigation including drug likeness, ADMET properties, molecular docking, and in vitro evaluations for possible antioxidant, antidiabetic, anti-AGEs actions. identified β-pinene (30%) as major component, succeeded by caryophyllene (29.37%), o-xylene (8.98%), aromadendrine (8.29%), α-himachalene (6.82%). Molecular docking showed significant interaction transcription regulators 1JIJ with Caryophyllene oxide (ΔG -7.5 (kJ mol-1), 3TOP -6.8 mol-1) 4F5S -7.7 mol-1). The EO exhibited elevated phenolic content (26.3±0.45 mg/G GAE) considerable antioxidant capacity DPPH (14.2±0.62), H2O2 (73.3±1.7), FRAP assays (312±14.6 μg). antidiabetic demonstrated notable inhibition α-glucosidase (IC50 0.12 mg/mL) advanced glycation end products (AGEs) both non-oxidative 0.052 oxidative modes 1.61 mg/mL). During mechanistic investigations it was observed exerts protective effect against β-amyloid formation significantly entraps carbonyl moieties. It P. has properties these finding support good potential management diabetes allied co-morbidities. In future formulation design studies can be helpful pharmaceutical industry to opt the formulation.

Language: Английский

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Harnessing nutrition to combat MASLD: a comprehensive guide to food-based therapeutic strategies

Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)

Published: May 6, 2025

Language: Английский

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Redox-Driven Epigenetic Modifications in Sperm: Unraveling Paternal Influences on Embryo Development and Transgenerational Health

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 570 - 570

Published: May 9, 2025

Male-factor infertility accounts for nearly half of all cases, and mounting evidence points to oxidative stress as a pivotal driver sperm dysfunction, genetic instability, epigenetic dysregulation. In particular, the DNA lesion 8-hydroxy-2′-deoxyguanosine (8-OHdG) has emerged central mediator at interface damage regulation. We discuss how this can disrupt key mechanisms such methylation, histone modifications, small non-coding RNAs, thereby influencing fertilization outcomes, embryo development, offspring health. propose that interplay between reprogramming is further exacerbated by aging in both paternal maternal germlines, creating “perfect storm” increases risk heritable (epi)mutations. The consequences unresolved lesions thus persist beyond fertilization, contributing transgenerational health risks. Finally, we explore promise potential pitfalls antioxidant therapy strategy mitigate damage. While supplementation may hold significant therapeutic value men with subfertility experiencing elevated stress, careful, personalized approach essential avoid reductive unintended disruptions. Recognizing dual role shaping genome epigenome underscores need integrating redox biology into reproductive medicine, aim improving fertility treatments safeguarding future generations.

Language: Английский

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Spent LiFePO4 to High-Value LiF: Enhanced Mechanical Chlorination Coupled with a Fluorination Reaction Mechanism

Processes, Journal Year: 2025, Volume and Issue: 13(5), P. 1478 - 1478

Published: May 12, 2025

LiFePO4 (LFP) batteries are among the earliest commercialized and most discarded lithium-ion batteries. Although existing recovery technologies focus on conversion of to Li2CO3, challenges associated with achieving near-full high-value products remain. This study proposes a strategy for spent LiF by mechanical chlorination coupled fluorination reaction. The optimum conditions were determined be ball-to-powder ratio (BPR) = 15, NH4Cl:LFP 3, H2O2 2.0 mL, rotation speed 600 rpm, grinding time 12 h. Results showed that 97.14% Li was converted into LiCl H2O2–NH4Cl chlorination. When chlorinated intermediates immersed in water, FePO4 could harvested, 96.79% recovered as purity 99.50% after adding NH4F. Cl-functionalized renewable resin used exchange 99.89% F−, 0.63 g NH4Cl per litre residual liquid derived. favourable results attributed 1O2 generated H2O2, which had strong electron affinity break Li–O bonds provided superior combination Cl. During fluorination, formation reduced ion concentration, entropy decreased, contributing spontaneous Therefore, proposed method paves way LiFePO4.

Language: Английский

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Effects of Carotenoid Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

International Journal of Sport Nutrition and Exercise Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: Jan. 1, 2025

Objective : This study aims to investigate the potential effects of carotenoid supplementation on mitigating exercise-induced oxidative stress and provide guidance for future research. Methods We conducted a systematic review meta-analysis using Preferred Reporting Items Systematic Reviews Meta-Analyses guidelines. searched multiple databases from inception August 2024 randomized clinical trials investigating biomarkers stress, inflammatory markers, antioxidant levels, metabolic parameters in context stress. The search terms included “carotenoids,” “supplementation,” “exercise,” “oxidative stress,” “inflammation,” “antioxidants,” “metabolic parameters,” their synonyms. Two reviewers independently extracted data, with disagreements resolved by third reviewer. Quality was assessed Cochrane risk-of-bias method. Random fixed models were used analysis standard mean differences (SMD) or weighted (MDs) 95% confidence intervals (CI). Results A total 12 studies final analysis. Carotenoid led significant assessing induced exercise (overall stress: SMD = −0.55, CI [−1.04, −0.06]; malondialdehyde: MD −0.05, [−0.09,−0.02]; capacity: 0.03, [0.02, 0.03]; 8-isoprostane: −35.70, [−59.32, −12.09]; lipid peroxide: −1.07, [−1.94, −0.20]; nitric oxide: −8.07, [−12.54,−3.59]), markers (inflammatory levels: 1.63, [0.81, 2.46]; interleukin 1.54, [0.69, 2.40]; C-reactive protein: 4.56, [0.97, 8.14]), levels (SMD 0.84, [0.14, 1.53]), (energy expenditure: −0.52, [−0.78, −0.26]; p < .05). Conclusion appears attenuate response improve capabilities. However, these results may be influenced participant variability methodological differences. Further research larger sample sizes, longer periods, higher doses, bioavailability is needed confirm findings.

Language: Английский

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From Inflammation to Infertility: How Oxidative Stress and Infections Disrupt Male Reproductive Health

Metabolites, Journal Year: 2025, Volume and Issue: 15(4), P. 267 - 267

Published: April 11, 2025

Inflammation, infections, and oxidative stress (OS) all have an impact on male infertility, which is a complicated, multifaceted illness. OS affects motility fertilization capability. It accomplishes this through damaging sperm DNA, oxidizing proteins, triggering lipid peroxidation. These effects occur due to imbalance between reactive oxygen species (ROS) antioxidant defenses. This review aims evaluate the of inflammation infertility by assessing recent literature. Pro-inflammatory cytokines, like TNF-α IL-6, interfere with spermatogenesis promote damage. Additionally, infections caused pathogens Escherichia coli Chlamydia trachomatis alter reproductive microenvironment, leading dysfunction inflammation. Early detection targeted treatment are essential intricate interactions among these elements. Microbiota-modulating techniques, antimicrobial therapies, anti-inflammatory drugs, antioxidants therapeutic approaches that may help reduce damage enhance fertility.

Language: Английский

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Antioxidants in cancer therapy mitigating lipid peroxidation without compromising treatment through nanotechnology

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 24, 2025

Cancer treatments often exploit oxidative stress to selectively kill tumour cells by disrupting their lipid peroxidation membranes and inhibiting antioxidant enzymes. However, plays a dual role in cancer progression, acting as both promoter suppressor. Balancing through therapy remains challenge, excessive activity may compromise the efficacy of chemotherapy radiotherapy. This review explores antioxidants mitigating while maintaining treatment efficacy. It highlights recent advancements nanotechnology-based targeted delivery optimize therapeutic outcomes. A comprehensive literature was conducted using reputable databases, including PubMed, Scopus, Web Science, ScienceDirect. The search focused on publications from past five years (2020-2025), supplemented relevant studies earlier years. Keywords such "antioxidants," "lipid peroxidation," "nanotechnology therapy," "oxidative stress" were utilized. Relevant articles critically analysed, graphical illustrations created. Emerging evidence suggests that nanoparticles, liposomes, polymeric metal-organic frameworks, others, can effectively encapsulate control release minimizing systemic toxicity. Stimuli-responsive carriers with tumour-specific targeting mechanisms further enhance delivery. Studies indicate these strategies help preserve normal cells, mitigate stress-related damage, improve challenges bioavailability, stability, potential interactions standard therapies remain. Integrating nanotechnology antioxidant-based interventions presents promising approach for optimizing therapy. Future research should focus refining modulation strategies, assessing profiles during treatment, employing biomarkers determine optimal dosing. balanced use adverse effects.

Language: Английский

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