Nutrients,
Journal Year:
2024,
Volume and Issue:
16(17), P. 2814 - 2814
Published: Aug. 23, 2024
Stress
is
a
critical
factor
in
the
development
of
mental
disorders
such
as
addiction,
underscoring
importance
stress
resilience
strategies.
While
ketogenic
diet
(KD)
has
shown
efficacy
reducing
alcohol
consumption
male
mice
without
cognitive
impairment,
its
impact
on
response
and
addiction
development,
especially
females,
remains
unclear.
This
study
examined
KD's
effect
increasing
ethanol
intake
due
to
vicarious
social
defeat
(VSD)
female
mice.
Sixty-four
OF1
were
divided
into
two
dietary
groups:
standard
(
Metabolic Brain Disease,
Journal Year:
2025,
Volume and Issue:
40(1)
Published: Jan. 8, 2025
Abstract
Current
treatment
approaches
for
Autism
spectrum
disorder
(ASD)
primarily
focus
on
symptom
management
rather
than
addressing
underlying
dysfunctions.
The
ketogenic
diet
(KD),
a
high-fat,
low-carbohydrate
inducing
nutritional
ketosis,
has
shown
promise
in
treating
epilepsy
and
may
offer
therapeutic
benefits
ASD
by
modulating
metabolic
neuroprotective
pathways.
This
review
examined
the
potential
impact
of
KD
mechanisms
ASD.
While
evidence
from
human
studies
is
limited,
animal
research
large
overlap
modulated
dysfunctions
As
such,
targeting
multiple
disrupted
pathways
at
once,
presents
multifaceted
approach
However,
more
needed
effectiveness
modulation
Additionally,
precision
medicine
could
help
identify
individuals
who
would
benefit
most
intervention,
potentially
extending
its
use
to
other
psychiatric
conditions
with
similar
patterns.
Consequently,
interventions
might
show
induce
drastic
paradigm
shift
understanding
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: May 14, 2024
Background
There
is
little
data
that
describe
the
use
of
ketogenic
metabolic
therapy
to
achieve
full
remission
major
depression
and
generalized
anxiety
disorder
in
clinical
practice.
We
present
a
retrospective
case
series
three
adults
with
complex
comorbidity,
treated
personalized
therapy,
who
achieved
complete
improvements
flourishing,
self-compassion,
health.
Methods
Three
adults,
ages
32–36,
depression,
anxiety,
other
disorders,
comorbid
psychiatric
conditions
were
for
12–16
weeks
whole
food
animal-based
(1.5:1
ratio)
specialized
psychiatry
Interventions
included
twice-weekly
visits
an
experienced
registered
dietitian;
daily
photo
journaling
capillary
blood
BHB/glucose/GKI
monitoring;
virtual
groups;
family/friends
support;
nature
walks
talks
several
times
per
week,
community
building.
Successful
adoption
diet
was
defined
as
achievement
maintenance
BHB
≥
0.8
mmol/L
GKI
<
6.
Remission
assessed
by
GAD-7
PHQ-9,
quality
life
subjectively
validated
scales
flourishing
self-compassion.
Metabolic
health
laboratories/biometric
measures.
Results
Two
patients
(PHQ-9
≤
4)
(GAD-7
within
7
therapeutic
nutritional
ketosis;
one
required
12
weeks.
Anxiety
responded
remitted
more
quickly
than
depression.
Flourishing
self-compassion
increased
steadily.
Patients
lost
10.9
14.8%
their
initial
body
weight
improved
metabolically;
optimal
Conclusion
Complete
occurred
7–12
ketosis
during
treatment
(ratio
1.5:1)
engaged
program.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(6), P. 979 - 979
Published: March 11, 2025
Drug-resistant
epilepsy
(DRE)
affects
20–30%
of
patients
with
who
fail
to
achieve
seizure
control
antiseizure
medications,
posing
a
significant
therapeutic
challenge.
In
this
narrative
review,
we
examine
the
clinical
efficacy
and
safety
classic
ketogenic
diet
(cKD)
its
variants,
including
modified
Atkins
(MAD),
medium-chain
triglyceride
(MCTD),
low
glycemic
index
treatment
(LGIT),
in
genetically
confirmed
drug-resistant
epilepsy.
These
diets
induce
metabolic
shift
from
glucose
ketones,
enhance
mitochondrial
function,
modulate
neurotransmitter
balance,
exert
anti-inflammatory
effects.
However,
genetic
factors
strongly
influence
cKD,
absolute
indications
transporter
type
1
deficiency
syndrome
(GLUT1DS)
pyruvate
dehydrogenase
complex
(PDCD).
Preferred
adjunctive
applications
KD
include
epilepsies,
such
as
SCN1A-related
Dravet
syndrome,
TSC1/TSC2-related
tuberous
sclerosis
complex,
UBE3A-related
Angelman
syndrome.
because
risk
decompensation,
cKD
is
contraindicated
pathogenic
variants
carboxylase
SLC22A5.
Recent
advancements
precision
medicine
suggest
that
microbiome
profiling
may
refine
patient
selection
optimize
KD-based
dietary
interventions.
Genome-wide
association
studies
multiomics
approaches
have
identified
key
pathways
influencing
response
these
pave
way
for
individualized
strategies.
Future
research
should
integrate
genomic,
metabolomic,
data
develop
biomarker-driven
protocols
improved
safety.
As
therapies
continue
evolve,
personalized
medical
approach
essential
maximize
their
utility
refractory
syndromes.
ACS Pharmacology & Translational Science,
Journal Year:
2025,
Volume and Issue:
8(3), P. 841 - 853
Published: Feb. 20, 2025
Alprazolam
(Alp),
a
commonly
used
sleep
medication
in
clinical
practice,
has
several
potential
limitations,
including
narrow
therapeutic
dosage
range
and
delayed
onset.
CGS21680
(CGS),
selective
agonist
of
the
adenosine
A2A
receptor,
exhibits
neuroinhibitory
properties.
This
study
aimed
to
evaluate
effects
CGS
on
properties
Alp.
The
sleep-inducing
Alp
were
assessed
through
righting
reflex,
while
sedative
evaluated
by
spontaneous
activity
detection.
synergistic
effect
was
using
electroencephalography
electromyography.
results
indicate
that
we
optimized
selected
ED5
dose
ED50
for
coadministration.
reduced
latency
induced
extended
duration.
distribution
brain
mass
spectrometry
imaging
(MSI).
blood-brain
barrier
(BBB)
model
established
impact
transmittance
indicated
influenced
across
various
regions
increased
Alp's
BBB.
metabolic
pathways
GABA,
glutamate,
glutamine
MSI
enzyme
verification.
coadministration
resulted
regulation
during
maintenance
periods,
respectively.
In
conclusion,
potentiating
is
attributed
its
ability
modulate
enhancing
BBB
permeability
influence
Alp-induced
neurotransmitter
release.
Annals of Clinical and Translational Neurology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 25, 2025
ABSTRACT
Dietary
manipulations
like
ketogenic
diets
are
established
interventions
for
recalcitrant
epilepsy.
However,
it
remains
unknown
whether
specific
macronutrient
exposure
through
dietary
environments
could
possibly
extend
to
primary
preventive
qualities,
associated
with
changes
in
epilepsy
disease
burden
(prevalence
and
incidence).
Here,
supply,
GDP,
idiopathic
data
were
collated
from
more
than
150
countries
1990
2018.
Nutritional
geometry
generalized
additive
mixed
models
(GAMMs)
modeling
unraveled
that
high‐fat
low‐carbohydrate
supplies
linked
lower
incidence
prevalence.
Our
analyses
suggested
a
plausible
role
of
