Obesity and the accelerated decline in total sleep time increases the self-reported diagnoses of diabetes DOI Creative Commons
Lijing L. Yan, Huanhuan Sun, Yuling Chen

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: May 12, 2025

The aim of this study was to investigate the relationship between obesity and accelerated decline in Total Sleep Time (TST) its potential impact on self-reported diagnoses diabetes. Our addresses gap by analyzing trends a longitudinal cohort conducted China, using data from China Health Nutrition Survey (CHNS). Employing joint model, inter-individual variability intra-individual TST, diabetes were considered. findings reveal that prevalence rose 1.10% 2004 3.06% 2015, accompanied decrease average TST 8.12 7.80. With age, decreased 0.01 per year. Among coffee or tea consumers, it 0.03, while alcohol users saw 0.07. obese group experienced 0.05, overweight normal weight 0.01. Each 1-hour associated with substantial 3.61-fold increase risk (95% CI: 2.92-4.44). Specifically, individuals higher baseline tend experience smaller changes over time, whereas those lower larger changes. For obese, decreases at an rate which contributes underscore role sleep loss risk, implications for public policy. Future research interventions should emphasise management, particularly metabolic health, develop more effective prevention treatment strategies.

Language: Английский

Raptin, a novel brain hormone links sleep health to body weight gain DOI Creative Commons

Leonie Cabot,

Henning Fenselau

Cell Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

Citations

0
Caveolin-1 negatively regulates the calcitonin receptor-like receptor and neuroinflammation in a female mouse model of migraine DOI Creative Commons
Yanjie Zhou, Chen Wu, Yu Zhang

et al.

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: May 21, 2025

Caveolin-1 (CAV1), a scaffolding protein critical for caveolae formation, regulates G-protein-coupled receptor (GPCR) signaling via caveolae-mediated endocytosis. The calcitonin receptor-like (CLR), GPCR and core subunit of the gene-related peptide (CGRP) receptor, is therapeutic target migraine. However, role CAV1 in CLR regulation migraine remains unclear. A model was established female mice dural inflammatory soup (IS) application. Migraine-like behaviors were assessed using Von Frey filament, spontaneous pain behavior counts, light/dark box, acetone test. overexpressed by lentivirus downregulated small interfering RNA (siRNA) technology. Methyl-β-cyclodextrin (MβCD) used to inhibit molecular mechanism on neuroinflammation investigated biochemistry, multiplex immunohistochemistry staining, internalization assay, co-immunoprecipitation. Repeated IS stimulation elevated expression trigeminal nucleus caudalis (TNC), concurrently activating ERK/CREB signaling, promoting microglial activation, increasing cytokines (TNFα, IL-1β). directly interacted with CLR, its degradation. knockdown TNC exacerbated pathology, characterized accumulation, enhanced phosphorylation, amplified neuroinflammation. Conversely, overexpression or MβCD-mediated disruption normalized levels, reduced hyperactivity, reversed nociceptive behaviors. negatively stability, suppressing inflammation preclinical model. These findings suggest that contributes migraine-related hyperalgesia may represent novel treatment.

Language: Английский

Citations

0
Obesity and the accelerated decline in total sleep time increases the self-reported diagnoses of diabetes DOI Creative Commons
Lijing L. Yan, Huanhuan Sun, Yuling Chen

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: May 12, 2025

The aim of this study was to investigate the relationship between obesity and accelerated decline in Total Sleep Time (TST) its potential impact on self-reported diagnoses diabetes. Our addresses gap by analyzing trends a longitudinal cohort conducted China, using data from China Health Nutrition Survey (CHNS). Employing joint model, inter-individual variability intra-individual TST, diabetes were considered. findings reveal that prevalence rose 1.10% 2004 3.06% 2015, accompanied decrease average TST 8.12 7.80. With age, decreased 0.01 per year. Among coffee or tea consumers, it 0.03, while alcohol users saw 0.07. obese group experienced 0.05, overweight normal weight 0.01. Each 1-hour associated with substantial 3.61-fold increase risk (95% CI: 2.92-4.44). Specifically, individuals higher baseline tend experience smaller changes over time, whereas those lower larger changes. For obese, decreases at an rate which contributes underscore role sleep loss risk, implications for public policy. Future research interventions should emphasise management, particularly metabolic health, develop more effective prevention treatment strategies.

Language: Английский

Citations

0