Evaluation of the association of chronic inflammation and cancer: Insights and implications

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 164, P. 115015 - 115015

Published: June 15, 2023

Among the most extensively researched processes in development and treatment of cancer is inflammatory condition. Although acute inflammation essential for wound healing reconstruction tissues that have been damaged, chronic may contribute to onset growth a number diseases, including cancer. By disrupting signaling cells, which result induction, invasion, development, variety molecules are linked The microenvironment surrounding tumor greatly influenced by cells their subsequent secretions, also significantly tumor's growth, survivability, potential migration. These variables mentioned several publications as prospective diagnostic tools anticipating Targeting with various therapies can reduce response potentially limit or block proliferation cells. scientific medical literature from past three decades has studied determine how chemicals cell pathways related invasion metastasis related. current narrative review updates relevant while highlighting specifics possible therapeutic possibilities.

Language: Английский

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Functional roles of sphingolipids in immunity and their implication in disease

Experimental & Molecular Medicine, Journal Year: 2023, Volume and Issue: 55(6), P. 1110 - 1130

Published: June 1, 2023

Abstract Sphingolipids, which are components of cellular membranes and organ tissues, can be synthesized or degraded to modulate responses according environmental cues, the balance among different sphingolipids is important for directing immune responses, regardless whether they originate, as intra- extracellular events. Recent progress in multiomics-based analyses methodological approaches has revealed that human health diseases closely related homeostasis sphingolipid metabolism, disease-specific alterations enzymes prognostic markers disease progression. Accumulating clinical data from genome-wide association studies preclinical models provide support notion missing pieces supplement our understanding functions involved proteins nucleotides have been established. In this review, we analyze sphingolipid-related reported understand roles metabolism. We discuss defects metabolism disease, along with functional cells. also introduce several summaries research on modulators review should helpful studying investigation experimental molecular medicines.

Language: Английский

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Augmenting Immunotherapy via Bioinspired MOF‐Based ROS Homeostasis Disruptor with Nanozyme‐Cascade Reaction

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(49)

Published: Sept. 10, 2023

Despite its remarkable clinical breakthroughs, immune checkpoint blockade (ICB) therapy remains limited by the insufficient response in "cold" tumor. Nanozyme-based antitumor catalysis is associated with precise activation tumor microenvironment (TME). In this study, a cascade-augmented nanoimmunomodulator (CMZM) multienzyme-like activities, which includes superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and glutathione oxidase (GSHOx), that dissociates under an acidic abundant GSH TME, proposed for multimodal imaging-guided chemodynamic (CDT)/photodynamic (PDT) enhanced immunotherapy. Vigorous activities can not only produce O2 to alleviate hypoxia promote polarization of M2 M1 macrophages, but also generate ROS (•OH 1 ) deplete TME expose necrotic cell fragments reverse immunosuppressive eliciting maturation dendritic cells infiltration cytotoxic T lymphocytes (CTLs) tumors. Therefore, inhibitory effects on both primary distant tumors are achieved through synergy α-PD-L1 blocking antibody. This cascade multienzyme-based nanoplatform provides smart strategy highly efficient ICB immunotherapy against revising TME.

Language: Английский

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cGAS-STING pathway mediates activation of dendritic cell sensing of immunogenic tumors

Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)

Published: March 21, 2024

Abstract Type I interferons (IFN-I) play pivotal roles in tumor therapy for three decades, underscoring the critical importance of maintaining integrity IFN-1 signaling pathway radiotherapy, chemotherapy, targeted therapy, and immunotherapy. However, specific mechanism by which IFN-I contributes to these therapies, particularly terms activating dendritic cells (DCs), remains unclear. Based on recent studies, aberrant DNA cytoplasm activates cyclic GMP-AMP synthase (cGAS)- stimulator interferon genes (STING) pathway, turn produces IFN-I, is essential antiviral anticancer immunity. Notably, STING can also enhance immunity promoting autophagy, inflammation, glycolysis an IFN-I-independent manner. These research advancements contribute our comprehension distinctions between drugs agonists context oncology shed light challenges involved developing agonist drugs. Thus, we aimed summarize novel mechanisms underlying cGAS-STING-IFN-I signal activation DC-mediated antigen presentation its role cancer immune cycle this review.

Language: Английский

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Type 2 immunity in allergic diseases

Cellular and Molecular Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

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Infinite Coordination Polymer Polydopamine Nanocomposites Dual‐Pathway Multistep Induction of Long‐Term Hyperimmunity Combined With Photothermal‐Chemo Synergistic Therapy Colorectal Cancer

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

ABSTRACT To improve the long‐term therapeutic efficacy of colorectal cancer, we propose a synergistic treatment strategy involving dual‐pathway, multistep induction hyperimmunity combined with photothermal‐chemotherapy. implement this strategy, infinite coordination polymer nanoparticles (SN38‐Mn(II)‐EGCG ICP NPs) were prepared by coordinating SN38, EGCG, and Mn 2+ . These then coated polydopamine (PDA) grafted folate‐PEG‐thiol (FA‐PEG‐SH) onto their surfaces, producing tumor‐targeting folate‐modified PDA nanocomposites (ICP@FA‐PDA nanocomposites). exhibit particle size 94.9 ± 1.6 nm high drug loading capacity (83.3% 1.5%), release under acidic conditions while maintaining stability in physiological environments. Furthermore, each component within serves multiple functions. Notably, incorporation components triggers powerful antitumor immune effect establishes enduring memory through dual‐pathway approach, which is produced activation cGAS‐STING pathway immunogenic cell death (ICD) four‐component process. Under low‐dose regimen, approach induces generates ultra‐long immunological memory, marked ninefold increase CD8 + T infiltration, fourfold CD4 lymphocytes, reduction Treg cells, fivefold cells. The remarkable therapy achieved combination SN38 EGCG chemotherapy photothermal therapy. In vivo studies demonstrated that mice treated ICP@FA‐PDA complete eradication cancer 21 days, no recurrence observed 60 days. hold significant promise potential for future clinical translation.

Language: Английский

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Dual-Enzyme-Instructed Peptide Self-Assembly to Boost Immunogenic Cell Death by Coordinating Intracellular Calcium Overload and Chemotherapy

ACS Nano, Journal Year: 2025, Volume and Issue: 19(1), P. 488 - 503

Published: Jan. 4, 2025

The concept of immunogenic cell death (ICD) induced by chemotherapy as a potential synergistic modality for cancer immunotherapy has been widely discussed. Unfortunately, most chemotherapeutic agents failed to dictate effective ICD responses due their defects in inducing potent signaling. Here, we report dual-enzyme-instructed peptide self-assembly platform CPMC (CPT-GFFpY-PLGVRK-Caps) that cooperatively utilizes camptothecin (CPT) and capsaicin (Caps) promote engage systemic adaptive immunity tumor rejection. Although CPT Caps respectively prevent progression inhibiting type-I DNA topoisomerase activating transient receptor cation channel subfamily V member 1 (TRPV1) intracellular calcium overload, neither alone effectively stimulates sufficient signaling meet immunotherapeutic needs. CPMC, sequentially allowing an active derivative VRK-Caps release extracellularly intracellularly, can synergize two distinct apoptosis pathways stimulated increase immunogenicity elicit T-cell-based immunity. Consequently, facilitates the generation improved tumor-specific cytotoxic T-cell sustained immunological memory, successfully suppressing both primary distant tumors. Moreover, render tumors susceptible PD-L1 blockade with antiprogrammed death-ligand (aPDL1) antibody inhibition. Combining drugs low ICD-stimulating capacity using strategy was demonstrated boost potentiate immunotherapy.

Language: Английский

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Ice-pop making inspired photothermal ultra-swelling microneedles to facilitate loading and intradermal vaccination of tumor antigen

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 77 - 88

Published: Jan. 8, 2025

Language: Английский

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The tumor microenvironment and dendritic cells: Developers of pioneering strategies in colorectal cancer immunotherapy?

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: 1880(2), P. 189281 - 189281

Published: Feb. 8, 2025

Language: Английский

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Kinsenoside attenuates liver fibro-inflammation by suppressing dendritic cells via the PI3K-AKT-FoxO1 pathway

Pharmacological Research, Journal Year: 2022, Volume and Issue: 177, P. 106092 - 106092

Published: Jan. 21, 2022

Language: Английский

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