Hepatic inflammatory responses in liver fibrosis

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2023, Volume and Issue: 20(10), P. 633 - 646

Published: July 3, 2023

Language: Английский

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Immunosuppressive tumor microenvironment and immunotherapy of hepatocellular carcinoma: current status and prospectives

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: April 29, 2024

Abstract Hepatocellular carcinoma (HCC) is a major health concern worldwide, with limited therapeutic options and poor prognosis. In recent years, immunotherapies such as immune checkpoint inhibitors (ICIs) have made great progress in the systemic treatment of HCC. The combination treatments based on ICIs been trend this area. Recently, dual blockade durvalumab plus tremelimumab has also emerged an effective for advanced However, majority HCC patients obtain benefits. Understanding immunological rationale exploring novel ways to improve efficacy immunotherapy drawn much attention. review, we summarize latest area, ongoing clinical trials immune-based therapies, well strategies chimeric antigen receptor T cells, personalized neoantigen vaccines, oncolytic viruses, bispecific antibodies.

Language: Английский

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Antitumor immunostimulatory activity of the traditional Chinese medicine polysaccharide on hepatocellular carcinoma

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 22, 2024

Hepatocellular carcinoma (HCC) is a prevalent malignancy, often associated with compromised immune function in affected patients. This can be attributed to the secretion of specific factors by liver cancer cells, which hinder response and lead state suppression. Polysaccharides derived from traditional Chinese medicine (TCM) are valuable constituents known for their immunomodulatory properties. review aims look into effects TCM polysaccharides on HCC. The primarily manifested through activation effector T lymphocytes, dendritic NK macrophages against hepatocellular both vivo vitro settings. Furthermore, have demonstrated remarkable adjuvant antitumor HCC clinical Therefore, utilization holds promising potential development novel therapeutic agents or adjuvants advantageous properties

Language: Английский

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Investigating the impact of antibiotic-induced dysbiosis on protection from Clostridium difficile colitis by mouse colonic innate lymphoid cells

mBio, Journal Year: 2024, Volume and Issue: 15(3)

Published: Feb. 20, 2024

ABSTRACT Innate lymphoid cells (ILCs) play a critical role in maintaining intestinal health homeostatic and diseased conditions. During Clostridium difficile infection (CDI), IL-33 activates ILC2 to protect from colonic damage mortality. The function of ILC is tightly regulated by the microbiota. We set out determine impact antibiotic-induced disruption microbiome on function. Our goal was understand changes susceptibility C. colitis mouse model. utilized high-throughput single-cell RNAseq investigate phenotypic features at baseline, after antibiotic administration with or without treatment. identified heterogeneous landscape ILCs gene signatures inflammatory, anti-inflammatory, migratory, progenitor, plastic, antigen-presenting ILCs. Antibiotic treatment decreased while coordinately increasing ILC1 ILC3 phenotypes. Notably, Ifng + , Ccl5 Il23r increased antibiotics. counteracted effect downregulating activating ILC2. In addition, markedly induced expression type 2 genes, including Areg Il5. Finally, we amphiregulin, produced ILC2, as protective during infection. Together, our data expand understanding how antibiotics induce through their subsets IMPORTANCE (CDI) accounts for around 500,000 symptomatic cases over 20,000 deaths annually United States alone. A major risk factor CDI dysbiosis gut. Microbiota-regulated innate are important determining outcomes Understanding alter phenotype colon identify potential therapeutics. Here, performed collected treatment, subpopulations all three subtypes colon. analysis revealed several pathways antibiotic-mediated discovery that abundantly expressed ILCs, protection mice amphiregulin suggests amphiregulin-epidermal growth receptor pathway therapeutic target treating colitis.

Language: Английский

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Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata

eLife, Journal Year: 2023, Volume and Issue: 12

Published: March 9, 2023

Here, we have explored the involvement of innate lymphoid cells-type 1 (ILC1) in pathogenesis alopecia areata (AA), because found them to be significantly increased around lesional and non-lesional HFs AA patients. To further explore these unexpected findings, first co-cultured autologous circulating ILC1-like cells (ILC1lc) with healthy, but stressed, organ-cultured human scalp hair follicles (HFs). ILClc induced all hallmarks ex vivo: they promoted premature, apoptosis-driven HF regression (catagen), cytotoxicity/dystrophy, most important for pathogenesis, collapse physiological immune privilege. NKG2D-blocking or IFNγ-neutralizing antibodies antagonized this. In vivo, intradermal injection activated, NKG2D+/IFNγ-secreting ILC1lc into healthy skin xenotransplanted onto SCID/beige mice sufficed rapidly induce characteristic lesions. This provides evidence that ILC1lc, which are positive ILC1 phenotype negative classical NK markers, suffice previously vivo questions conventional wisdom is always an autoantigen-dependent, CD8 +T cell-driven autoimmune disease.

Language: Английский

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The aryl hydrocarbon receptor: a rehabilitated target for therapeutic immune modulation

Nature Reviews Drug Discovery, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

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Circulating innate lymphoid cells are dysregulated in patients with prostate cancer

Cellular & Molecular Biology Letters, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 18, 2025

Language: Английский

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Decoding innate lymphoid cells and innate-like lymphocytes in asthma: pathways to mechanisms and therapies

Journal of Biomedical Science, Journal Year: 2025, Volume and Issue: 32(1)

Published: May 12, 2025

Abstract Asthma is a chronic inflammatory lung disease driven by complex interplay between innate and adaptive immune components. Among these, lymphoid cells (ILCs) innate-like lymphocytes have emerged as crucial players in shaping the phenotype. Within ILC family, group 2 ILCs (ILC2s), particular, contribute significantly to type inflammation through their rapid production of cytokines such IL-5 IL-13, promoting airway eosinophilia hyperreactivity. On other hand, invariant natural killer T (iNKT) can play either pathogenic or protective roles asthma, depending on stimuli microenvironment. Regulatory mechanisms, including cytokine signaling, metabolic dietary cues, interactions with cells, critical modulating functions. In this review, we highlight current findings role asthma development pathogenesis. We also examine underlying mechanisms regulating function cells. Finally, explore therapies targeting these effector for management.

Language: Английский

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NK cell marker gene-based model shows good predictive ability in prognosis and response to immunotherapies in hepatocellular carcinoma

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: May 5, 2023

Abstract Hepatocellular carcinoma (HCC) is the fourth leading cause of malignancy worldwide, and its progression influenced by immune microenvironment. Natural killer (NK) cells are essential in anti-tumor response have been linked to immunotherapies for cancers. Therefore, it important unify validate role NK cell-related gene signatures HCC. In this study, we used RNA-seq analysis on HCC samples from public databases. We applied ConsensusClusterPlus tool construct consensus matrix cluster based their expression profile data. employed least absolute shrinkage selection operator regression identify hub genes. Additionally, utilized CIBERSORT ESTIMATE web-based methods perform immune-related evaluations. Our results showed that gene-based classification divided patients into three clusters. The C3 was activated activation signaling pathways better prognosis good clinical features. contrast, C1 remarkably enriched cell cycle pathways. stromal score, score were much higher than those C2 C1. Furthermore, identified six genes: CDC20, HMOX1, S100A9, CFHR3, PCN1, GZMA. genes-based risk subgroups demonstrated a subgroup poorer prognosis. summary, our findings suggest genes play an prediction therapeutic potential promoting antitumor immunity. may serve as useful biomarkers novel targets.

Language: Английский

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Impact of immune tolerance mechanisms on the efficacy of immunotherapy in primary and secondary liver cancers

Translational Gastroenterology and Hepatology, Journal Year: 2023, Volume and Issue: 8, P. 29 - 29

Published: July 1, 2023

: The liver is a functionally unique organ with an immunosuppressive microenvironment. the sixth most common site of primary cancer in humans and frequent metastasis from other solid tumors. development effective therapies for metastatic has been challenging due to complex metabolic immune microenvironment liver. tumor (TME) secondary (metastatic) cancers heterogenous consists stromal cell populations. Crosstalk between these populations cells creates within which potentiates progression. Immune checkpoint inhibitors (ICIs) are now clinically approved management can partially overcome tolerance, but their efficacy limited. In this review, we describe use immunotherapy cancer. We discuss emerging combination strategies utilizing locoregional systemic therapy approaches may enhance A deeper understanding will inform novel therapeutic combinations order improve outcomes patients

Language: Английский

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