NK cell-derived IFNγ mobilizes free fatty acids from adipose tissue to promote early B cell activation during viral infection

Nature Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

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A Dual‐Targeting Biomimetic Nanoplatform Integrates SDT/CDT/Gas Therapy to Boost Synergistic Ferroptosis for Orthotopic Hepatocellular Carcinoma Therapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract The development of efficient therapeutic strategies to promote ferroptotic cell death offers significant potential for hepatocellular carcinoma (HCC) treatment. Herein, this study presents an HCC‐targeted nanoplatform that integrates bimetallic FeMoO 4 nanoparticles with CO‐releasing molecules, and further camouflaged SP94 peptide‐modified macrophage membrane enhanced ferroptosis‐driven multi‐modal therapy HCC. Leveraging the multi‐enzyme activities multivalent metallic elements, not only decomposes H 2 O generate oxygen alleviate tumor hypoxia but also depletes glutathione inactivate peroxides 4, which amplify sonodynamic under ultrasound (US) irradiation. Meanwhile, catalyzes Fenton reaction produce hydroxyl radicals chemodynamic therapy. Elevated intracellular reactive species trigger cascade release CO, leading lethal lipid peroxidation enhancing ferroptosis‐mediated This demonstrates robust anti‐tumor efficacy US irradiation favorable biosafety in both subcutaneous orthotopic HCC models, representing a promising approach Additionally, findings offer new insights into microenvironment modulation optimize US‐triggered cancer

Language: Английский

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Association between serum cotinine concentrations on red blood cell folate concentrations in pregnant women and the mediating role of lymphocytes: an NHANES Study

Archives of Public Health, Journal Year: 2025, Volume and Issue: 83(1)

Published: Feb. 21, 2025

Folate is essential for DNA synthesis and cell division, particularly during pregnancy, where insufficient levels can lead to adverse outcomes like neural tube defects preterm birth. Tobacco smoke exposure, indicated by serum cotinine levels, a known risk factor reduced folate levels. However, the mechanisms underlying this relationship, especially role of lymphocytes, are not well understood. This study evaluates relationship between RBC concentrations in pregnant women, explores mediating lymphocyte count, identifies susceptibility factors that could guide targeted interventions. We conducted cross-sectional analysis using NHANES data from 1999 2018, including 1,021 women. Serum were used as biomarker tobacco while long-term status. Linear regression, restricted cubic spline, mediation analyses performed assess these relationships. significantly negatively correlated with (P < 0.001). A nonlinear revealed more pronounced depletion at higher Mediation showed elevated count mediated 19.3% cotinine-folate association. Factors such smoking history, advanced maternal age, heavy alcohol consumption exacerbated negative effect. exposure(as reflected levels) reduces playing role. These findings underscore need public health interventions mitigate tobacco-related risks pregnancy.

Language: Английский

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Tissue-specific antiviral immunity

Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: 21(9), P. 941 - 942

Published: Aug. 13, 2024

Language: Английский

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