Unlocking the Untapped Potential of Photoresponsive Dual‐Gas Nanomedicine in Glaucoma Therapy

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract Glaucoma, a leading cause of irreversible blindness worldwide, is characterized by optic nerve damage often associated with elevated intraocular pressure (IOP). Although gas therapies hold promise for glaucoma treatment, the limitations single‐gas strategies constrain their therapeutic efficacy. Here, photoresponsive dual‐gas nanomedicine developed targeted therapy. The nanomedicine, PdH‐D‐S, engineered synthesizing mesoporous palladium hydride (meso‐PdH) efficient hydrogen (H₂) storage capacity and abundant pore channels, followed surface modification DSPE‐mPEG loading sodium nitroprusside (SNP) as nitric oxide (NO) donor. PdH‐D‐S penetrates cornea to reach IOP‐regulating tissues, including trabecular meshwork Schlemm's canal. Upon 808 nm laser excitation, releases H₂ NO in controlled manner. activates AKT/p‐AKT/eNOS/sGC signaling pathway, while binds soluble guanylate cyclase (sGC), converting guanosine triphosphate (GTP) cyclic monophosphate (cGMP), relaxing cells enhancing aqueous humor outflow. This system demonstrates high efficacy lowering IOP offers mechanistic advancement treatment through synergistic

Language: Английский

Magnesium-assisted hydrogen improves isoproterenol-induced heart failure

Medical Gas Research, Journal Year: 2025, Volume and Issue: 15(4), P. 459 - 470

Published: April 29, 2025

Heart failure (HF) is a leading cause of mortality among patients with cardiovascular disease and often associated myocardial apoptosis endoplasmic reticulum stress (ERS). While hydrogen has demonstrated potential in reducing oxidative ERS, recent evidence suggests that magnesium may aid release within the body, further enhancing these protective effects. This study aimed to investigate cardioprotective effects ERS through rat model isoproterenol (ISO)-induced HF. Magnesium was administered orally ISO-induced HF rats, which improved cardiac function, reduced fibrosis hypertrophy, lowered plasma levels creatine kinase-MB, troponin-I, N-terminal B-type natriuretic peptide precursor rats. It also inhibited cardiomyocyte by upregulating B-cell lymphoma-2, downregulating Bcl-2-associated X protein, suppressing markers (glucose-related protein 78, activating transcription factor 4, C/EBP-homologous protein). elevated blood, plasma, tissue, as well artificial gastric juice pure water, where lasted for at least four hours. Additionally, complementary vitro experiments were conducted using H9C2 injury models, hydrogen-rich culture medium intervention. Hydrogen-rich survival proliferation ISO-treated cells, cell surface area, apoptosis, downregulated pathway proteins. However, negated tunicamycin (an inducer ERS) cells. In conclusion, exerts significant cardioprotection mitigating

Language: Английский

Frailty and Visual Impairment in Elderly Individuals: Improving Outcomes and Modulating Cognitive Decline Through Collaborative Care Between Geriatricians and Ophthalmologists

Diseases, Journal Year: 2024, Volume and Issue: 12(11), P. 273 - 273

Published: Nov. 1, 2024

: As life expectancy increases, the prevalence of frailty and eye diseases (cataracts, glaucoma, age-related macular degeneration (AMD), diabetic retinopathy) in elderly global population is rising. Eye visual impairment not only contribute to a high incidence falls, fractures, depression, social isolation but they also herald cognitive decline (vision-cognitive impairment).

Language: Английский