ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(5), P. 8233 - 8243
Published: May 2, 2022
Photovoltaic
biointerfaces
offer
wireless
and
battery-free
bioelectronic
medicine
via
photomodulation
of
neurons.
Near-infrared
(NIR)
light
enables
communication
with
neurons
inside
the
deep
tissue
application
high
photon
flux
within
ocular
safety
limit
exposure.
For
that,
nonsilicon
are
highly
demanded
for
thin
flexible
operation.
Here,
we
devised
a
quantum
dot
(QD)-based
photovoltaic
biointerface
that
stimulates
cells
spectral
transparency
window
by
using
NIR
(λ
=
780
nm).
Integration
an
ultrathin
QD
layer
25
nm
into
multilayered
architecture
transduction
to
safe
capacitive
ionic
currents
leads
reproducible
action
potentials
on
primary
hippocampal
success
rates.
The
exhibit
low
in
vitro
toxicity
robust
photoelectrical
performance
under
different
stability
tests.
Our
findings
show
colloidal
dots
can
be
used
brain,
heart,
retina.
Advanced Drug Delivery Reviews,
Journal Year:
2020,
Volume and Issue:
170, P. 396 - 424
Published: Sept. 26, 2020
Electroactive
materials
are
employed
at
the
interface
of
biology
and
electronics
due
to
their
advantageous
intrinsic
properties
as
soft
organic
electronics.
We
examine
most
recent
literature
electroactive
material-based
biosensors
emerging
role
theranostic
devices
for
delivery
therapeutic
agents.
consider
through
lens
smart
drug
systems
that
enable
release
cargo
in
response
specific
physiological
external
stimuli
discuss
way
these
mechanisms
integrated
into
medical
with
examples
latest
advances.
Studies
harness
features
unique
conductive
polymers
emphasized;
lastly,
we
highlight
new
perspectives
future
research
direction
this
technology
challenges
remain
overcome.
Advanced Healthcare Materials,
Journal Year:
2021,
Volume and Issue:
10(17)
Published: April 25, 2021
Abstract
Owing
to
their
excellent
mechanical
flexibility,
mixed‐conducting
electrical
property,
and
extraordinary
chemical
turnability,
conjugated
polymers
have
been
demonstrated
be
an
ideal
bioelectronic
interface
deliver
therapeutic
effect
in
many
different
chronic
diseases.
This
review
article
summarizes
the
latest
advances
implantable
electronics
using
as
electroactive
materials
identifies
remaining
challenges
opportunities
for
developing
electronic
medicine.
Examples
of
polymer‐based
devices
are
selectively
reviewed
human
clinical
studies
or
animal
with
potential
adoption.
The
unique
properties
highlighted
exemplified
solutions
address
specific
Journal of the American Chemical Society,
Journal Year:
2022,
Volume and Issue:
144(11), P. 4853 - 4862
Published: March 9, 2022
Conducting
polymers
(CPs)
find
applications
in
energy
conversion
and
storage,
sensors,
biomedical
technologies
once
processed
into
thin
films.
Hydrophobic
CPs,
like
poly(3,4-ethylenedioxythiophene)
(PEDOT),
typically
require
surfactant
additives,
such
as
poly(styrenesulfonate)
(PSS),
to
aid
their
aqueous
processability
However,
excess
PSS
diminishes
CP
electrochemical
performance,
biocompatibility,
device
stability.
Here,
we
report
the
electrosynthesis
of
PEDOT
films
at
a
polarized
liquid|liquid
interface,
method
nonreliant
on
conductive
solid
substrates
that
produces
free-standing,
additive-free,
biocompatible,
easily
transferrable,
scalable
2D
any
shape
or
size
single
step
ambient
conditions.
Electrochemical
control
film
nucleation
growth
interface
allows
over
morphology,
transitioning
from
(flat
both
sides
with
thickness
<50
nm)
“Janus”
3D
(with
flat
rough
sides,
each
showing
distinct
physical
properties,
>850
The
were
p-doped
(approaching
theoretical
limit),
showed
high
π–π
conjugation,
directly
without
insulating
thus
highly
post-processing.
This
work
demonstrates
interfacial
distinctive
molecular
architectures
inaccessible
bulk
solution
electrode–electrolyte
interfaces
emergent
properties
facilitate
technological
advances.
In
this
regard,
demonstrate
film’s
superior
biocompatibility
scaffolds
for
cellular
growth,
opening
immediate
organic
transistor
(OECT)
devices
monitoring
cell
behavior
extended
time
periods,
bioscaffolds,
medical
devices,
needing
physiologically
unstable
poorly
biocompatible
PSS.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: June 27, 2022
Abstract
Retinal
prostheses
hold
the
potential
for
artificial
vision
in
blind
people
affected
by
incurable
diseases
of
outer
retinal
layer.
Available
technologies
provide
only
a
small
field
view:
significant
limitation
totally
people.
To
overcome
this
problem,
we
recently
proposed
large
and
high-density
photovoltaic
epiretinal
device,
known
as
POLYRETINA.
Here,
report
vivo
assessment
First,
characterise
model
chemically-induced
blindness
Göttingen
minipigs.
Then,
develop
test
minimally
invasive
injection
procedure
to
insert
implant
into
eye.
Last,
show
that
POLYRETINA
restores
light-evoked
cortical
responses
animals
at
safe
irradiance
levels.
These
results
indicate
holds
patients
retinitis
pigmentosa.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(10), P. 3326 - 3352
Published: Jan. 1, 2023
This
review
summarizes
optical
nanomaterials,
devices,
and
systems
for
neuromodulation.
We
describe
their
structures,
working
principles
bioelectronic
applications
with
challenges
prospects.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: May 27, 2024
Abstract
Retinal
degeneration,
a
leading
cause
of
irreversible
low
vision
and
blindness
globally,
can
be
partially
addressed
by
retina
prostheses
which
stimulate
remaining
neurons
in
the
retina.
However,
existing
electrode-based
treatments
are
invasive,
posing
substantial
risks
to
patients
healthcare
providers.
Here,
we
introduce
completely
noninvasive
ultrasonic
prosthesis,
featuring
customized
ultrasound
two-dimensional
array
allows
for
simultaneous
imaging
stimulation.
With
synchronous
three-dimensional
guidance
auto-alignment
technology,
prosthesis
generate
programmed
waves
dynamically
precisely
form
arbitrary
wave
patterns
on
Neuron
responses
brain’s
visual
center
mirrored
these
patterns,
evidencing
successful
artificial
creation,
was
further
corroborated
behavior
experiments.
Quantitative
analysis
spatial-temporal
resolution
field
view
demonstrated
advanced
performance
elucidated
biophysical
mechanism
retinal
As
could
lead
more
effective,
widely
acceptable
treatment
blind
patients.
Its
real-time
imaging-guided
stimulation
strategy
with
single
array,
also
benefit
neurostimulation
other
diseases.
Advanced Materials Interfaces,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 7, 2025
Abstract
Light
activated
local
stimulation
and
sensing
of
biological
cells
hold
great
promise
for
minimally
invasive
bioelectronic
interfaces.
Organic
semiconductors
are
particularly
appealing
these
applications
due
to
their
optoelectronic
properties
biocompatibility.
This
study
examines
the
material
necessary
localize
optical
excitation
achieve
transduction
with
high
spatial
resolution.
Using
photovoltage
photocurrent
microscopy,
we
investigate
broadening
in
Phthalocyanine/3,4,9,10‐Perylenetetracarboxylic
diimide
(H
2
PC/PTCDI)
planar
heterojunctions.
Our
measurements
reveal
that
resolution
losses
tied
effective
diffusion
length
charge
carriers
at
heterojunction.
For
H
PC/PTCDI
heterojunction,
is
determined
be
λ
d
=
1.5
±
0.1
µm,
attributed
reduced
carrier
mobility.
Covering
heterojunction
poly(3,4‐ethylenedioxythiophene)
polystyrene
sulfonate
(PEDOT:PSS)
improves
generation
performance
but
increases
7.0
0.3
µm
longer
lifetime
higher
These
findings
elucidate
physical
mechanisms
underlying
provide
design
principles
organic
semiconductor
devices
aimed
achieving
efficiency
wireless
optically
bioelectronics.
Frontiers in Neuroscience,
Journal Year:
2018,
Volume and Issue:
12
Published: Sept. 19, 2018
Reducing
the
mechanical
mismatch
between
stiffness
of
a
neural
implant
and
softness
tissue
is
still
an
open
challenge
in
neuroprosthetics.
The
emergence
conductive
hydrogels
last
few
years
has
considerably
widened
spectrum
possibilities
to
tackle
this
issue.
Nevertheless,
despite
advancements
field,
further
improvements
on
fabrication
hydrogel-based
electrodes
are
required.
In
work,
we
report
microelectrode
array
for
recording
using
hybrid
material
composed
poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)
alginate.
properties
hydrogel
have
been
investigated
imaging
techniques,
while
electrode
arrays
electrochemically
characterized
at
each
step
successfully
validated
both
in-vitro
in-vivo.
presence
hydrogel,
selectively
electrodeposited
onto
platinum
microelectrodes,
allowed
achieving
superior
electrochemical
characteristics,
leading
lower
electrical
noise
during
recordings.
These
findings
represent
advancement
design
soft
neuroprosthetic
applications.
Physiological Reviews,
Journal Year:
2020,
Volume and Issue:
unknown
Published: March 19, 2020
Impairments
of
vision
and
hearing
are
highly
prevalent
conditions
limiting
the
quality
life
presenting
a
major
socioeconomic
burden.
For
long,
retinal
cochlear
disorders
have
remained
intractable
for
causal
therapies,
with
sensory
rehabilitation
limited
to
glasses,
aids,
electrical
or
implants.
Recently,
application
gene
therapy
optogenetics
eye
ear
has
generated
hope
fundamental
improvement
restoration.
To
date,
one
restoration
been
approved
undergoing
clinical
trials
will
broaden
its
including
replacement,
genome
editing,
regenerative
approaches.
Moreover,
optogenetics,
i.e.
controlling
activity
cells
by
light,
offers
more
general
alternative
strategy.
Over
little
than
decade,
optogenetic
approaches
developed
applied
better
understand
function
biological
systems,
while
protein
engineers
identified
designed
new
opsin
variants
desired
physiological
features.
Considering
potential
applications
spotlight
is
on
systems.
Multiple
efforts
undertaken
restore
lost
hampered
in
ear.
Optogenetic
stimulation
promises
overcome
shortcomings
stimulation,
namely
poor
spatial
resolution
cellular
specificity,
accordingly
deliver
detailed
information.
This
review
aims
at
providing
comprehensive
reference
current
therapeutic
research
relevant
vision.
We
introduce
gene-therapeutic
discuss
biotechnological
optoelectronic
aspects
