Influence of the Mediterranean Diet on Healthy Aging

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4491 - 4491

Published: Feb. 24, 2023

The life expectancy of the global population has increased. Aging is a natural physiological process that poses major challenges in an increasingly long-lived and frail population. Several molecular mechanisms are involved aging. Likewise, gut microbiota, which influenced by environmental factors such as diet, plays crucial role modulation these mechanisms. Mediterranean well components present it, offer some proof this. Achieving healthy aging should be focused on promotion lifestyle habits reduce development pathologies associated with aging, order to increase quality In this review we analyze influence diet pathways microbiota more favorable patterns, its possible anti-aging treatment.

Language: Английский

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Control of immune cell function by the unfolded protein response

Nature reviews. Immunology, Journal Year: 2023, Volume and Issue: 23(9), P. 546 - 562

Published: Feb. 8, 2023

Language: Английский

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IRE1 signaling increases PERK expression during chronic ER stress

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(4)

Published: April 18, 2024

The Unfolded Protein Response (UPR) is an essential cellular process activated by the accumulation of unfolded proteins within Endoplasmic Reticulum (ER), a condition referred to as ER stress. Three anchored receptors, IRE1, PERK and ATF6 act stress sensors monitoring health ER. Upon detection stress, initiate downstream signaling pathways collectively UPR. overarching aim UPR restore homeostasis reducing however if that not possible, transitions from pro-survival pro-death response. While our understanding key central well defined, same true subtle events help fine tune UPR, supporting its ability adapt varying amplitudes or durations In this study, we demonstrate cross talk between IRE1 branches wherein via XBP1s helps sustain expression during prolonged Our findings suggest aids adaptiveness thereby helping support plasticity responses.

Language: Английский

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Cellular and Molecular Mechanisms Underlying Prostate Cancer Development: Therapeutic Implications

Medicines, Journal Year: 2019, Volume and Issue: 6(3), P. 82 - 82

Published: July 30, 2019

Prostate cancer is the most frequent nonskin and second common cause of cancer-related deaths in man. a clinically heterogeneous disease with many patients exhibiting an aggressive progression, metastasis, other showing indolent low tendency to progression. Three stages development human prostate tumors have been identified: intraepithelial neoplasia, adenocarcinoma androgen-dependent, androgen-independent or castration-resistant. Advances molecular technologies provided very rapid progress our understanding genomic events responsible for initial progression cancer. These studies shown that genome displays relatively mutation rate compared cancers few chromosomal loss gains. The ensemble these has led suggest existence two main groups cancers: one characterized by presence ERG rearrangements (~50% harbor recurrent gene fusions involving ETS transcription factors, fusing 5′ untranslated region androgen-regulated TMPRSS2 nearly coding sequence family factor ERG) features chemoplexy (complex developing from coordinated simultaneous event), absence mutations E3 ubiquitin ligase adapter SPOP and/or deletion CDH1, chromatin remodeling factor, interchromosomal are early during development. During epigenomic abnormalities accrued converged on pathways, leading highly transcriptomic landscape, hyperactive androgen receptor signaling axis.

Language: Английский

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ER Stress and the UPR in Shaping Intestinal Tissue Homeostasis and Immunity

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10

Published: Dec. 4, 2019

An imbalance in the correct protein folding milieu of endoplasmic reticulum (ER) can cause ER stress, which leads to activation unfolded response (UPR). The UPR constitutes a highly conserved and intricately regulated group pathways that serve restore homeostasis through adaptation or apoptosis. Numerous studies over last decade have shown plays critical role shaping immunity inflammation, resulting recognition as key player pathological processes including complex inflammatory, autoimmune neoplastic diseases. intestinal epithelium, with its many secretory cells, forms an important barrier messenger between luminal environment host immune system. It is not surprising, numerous associated stress diseases such inflammatory bowel disease (IBD) colorectal cancer (CRC). In this review, we discuss our current understanding roles responses maintaining tissue homeostasis. Furthermore, played by disease, particularly emphasis ion inflammation cancerIBD CRC, described here. As has been increasingly recognized pharmacological target development therapeutic strategies for immune-mediated pathologies. We summarize available targeting their implications. Understanding balance pathophysiology, well means manipulating balance, provides avenue future research.

Language: Английский

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IRE1α–XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain

Science, Journal Year: 2019, Volume and Issue: 365(6450)

Published: July 18, 2019

A “sUPR” target for pain management? The unfolded protein response (UPR) is initiated when or misfolded proteins accumulate in the endoplasmic reticulum. One highly conserved arm of UPR, IRE1α–XBP1 signaling pathway, also plays a role various other UPR-independent processes, including hypoxia, angiogenesis, and inflammation. Chopra et al. report that this pathway additionally regulates production two molecules, cyclooxygenase 2 microsomal prostaglandin E synthase 1, help mediate inflammation-induced (see Perspective by Avril Chevet). When elements were knocked out, behaviors reduced different mouse models pain. Targeting may result improved management therapies. Science , issue p. eaau6499 ; see 224

Language: Английский

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The emerging role of XBP1 in cancer

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 127, P. 110069 - 110069

Published: April 12, 2020

X-box binding protein 1 (XBP1) is a unique basic-region leucine zipper (bZIP) transcription factor whose dynamic form controlled by an alternative splicing response upon disturbance of homeostasis in the endoplasmic reticulum (ER) and activation unfolded (UPR). XBP1 was first distinguished as key regulator major histocompatibility complex (MHC) class II gene expression B cells. communicates with foremost conserved signalling component UPR essential for cell fate determination to ER stress (ERS). Here, we review recent advances our understanding this multifaceted translation cancer. In review, briefly discuss role mediators transcriptional function XBP1. addition, describe how operates tumour progression metastasis. We mainly XBP1's expression, prognostic value research on solid tumours. Finally, multiple approaches, especially those involving XBP1, that overcome immunosuppressive effect cancer could potentially be useful antitumour therapies.

Language: Английский

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Pharmacological Targeting of IRE1 in Cancer

Trends in cancer, Journal Year: 2020, Volume and Issue: 6(12), P. 1018 - 1030

Published: Aug. 26, 2020

Language: Английский

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Dysregulation of the splicing machinery is directly associated to aggressiveness of prostate cancer

EBioMedicine, Journal Year: 2020, Volume and Issue: 51, P. 102547 - 102547

Published: Jan. 1, 2020

Language: Английский

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Antioxidant Role of Kaempferol in Prevention of Hepatocellular Carcinoma

Antioxidants, Journal Year: 2021, Volume and Issue: 10(9), P. 1419 - 1419

Published: Sept. 5, 2021

Reactive oxygen species (ROS) are noxious to cells because their increased level interacts with the body’s defense mechanism. These also cause mutations and uncontrolled cell division, resulting in oxidative stress (OS). Prolonged is responsible for incorrect protein folding endoplasmic reticulum (ER), causing a stressful condition, ER stress. cellular stresses (oxidative stress) well-recognized biological factors that play prominent role progression of hepatocellular carcinoma (HCC). HCC critical global health problem third leading cancer-related mortality. The application anti-oxidants from herbal sources significantly reduces Kaempferol (KP) naturally occurring, aglycone dietary flavonoid present various plants (Crocus sativus, Coccinia grandis, Euphorbia pekinensis, varieties Aloe vera, etc.) It capable interacting pleiotropic proteins human body. Efforts progress develop KP as potential candidate prevent no adverse effects. This review emphasizes molecular mechanism treating HCC, targeting

Language: Английский

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