The Journal of Physiology,
Journal Year:
2022,
Volume and Issue:
601(22), P. 5011 - 5031
Published: March 23, 2022
Extended
periods
of
bed
rest
and
limb
immobilization
are
required
for
healing
post-injury
or
disease,
yet
disuse
can
result
in
significant
muscle
atrophy
decreased
quality
life
older
adults.
Physical
rehabilitation
is
commonly
prescribed
to
recover
these
deficits,
accumulation
reactive
oxygen
species
sustained
rates
protein
degradation
persist
during
the
period
that
significantly
delay
prevent
recovery.
Pericytes,
considered
primary
mesenchymal
vascular
stromal
cell
skeletal
muscle,
secrete
beneficial
factors
maintain
baseline
mass,
minimal
information
exists
regarding
pericyte
response
In
current
study,
single-cell
RNA
sequencing
functional
assays
were
performed
demonstrate
pericytes
mouse
lose
capacity
synthesize
antioxidants
This
was
used
guide
design
a
strategy
which
healthy
donor
stimulated
with
hydrogen
peroxide
(H
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Sept. 2, 2023
Abstract
Reprogramming
of
vascular
smooth
muscle
cell
(VSMC)
differentiation
plays
an
essential
role
in
abdominal
aortic
aneurysm
(AAA).
However,
the
underlying
mechanisms
are
still
unclear.
We
explore
expression
FAM3A,
a
newly
identified
metabolic
cytokine,
and
whether
how
FAM3A
regulates
VSMC
AAA.
discover
that
is
decreased
aortas
plasma
AAA
patients
murine
models.
Overexpression
or
supplementation
significantly
attenuate
formation,
manifested
by
maintenance
well-differentiated
status
inhibition
transformation
toward
macrophage-,
chondrocyte-,
osteogenic-,
mesenchymal-,
fibroblast-like
subpopulations.
Importantly,
induces
KLF4
ubiquitination
reduces
its
phosphorylation
nuclear
localization.
Here,
we
report
as
fate-shaping
regulator
reveal
mechanism
associated
with
stability,
which
may
lead
to
development
strategies
based
on
restore
homeostasis
The FASEB Journal,
Journal Year:
2020,
Volume and Issue:
34(6), P. 7500 - 7519
Published: April 12, 2020
Mitochondrial
abnormalities
play
critical
roles
in
diabetic
tubular
injury
progression.
Dipeptidyl
peptidase-4
(DPP4)
inhibitors
are
widely
used
antihyperglycemic
agents
that
exert
renal
protective
and
positive
effects
against
mitochondrial
dysfunction
kidney
disease
(DKD).
However,
their
underlying
mechanism
remains
unclear.
In
this
study,
DPP4
upregulation,
fragmentation,
altered
dynamics-associated
protein
expression
were
observed
the
tubules
of
DBA2/J
(D2)
mice
with
unilateral
nephrectomy
albumin-stimulated
cells.
The
inhibition
by
sitagliptin
(Sita)
ameliorated
these
perturbations
both
vivo
vitro,
whereas
overexpression
aggravated
fusion-fission
disorder
cell
albumin-treated
HK-2
Downstream
DPP4,
SDF-1α/CXCR4
pathway
was
significantly
suppressed
tubules.
After
Sita
treatment,
signaling
restored,
dynamics
improved.
Furthermore,
a
direct
interaction
between
STAT3
OPA1
found
mitochondria
cells,
effect
weakened
overloading
albumin
CXCR4
siRNA
suggesting
possible
link
DPP4-mediated
SDF-1α/CXCR4/STAT3
results
suggest
novel
links
enzyme
to
impaired
homeostasis
during
DKD
highlight
could
become
potential
target
for
managing
DKD.
Proceedings of the National Academy of Sciences,
Journal Year:
2021,
Volume and Issue:
118(13)
Published: March 22, 2021
Significance
This
work
investigated
the
in
vivo
role
of
Paxbp1,
a
poorly
studied
nuclear
protein,
regulating
adult
mouse
muscle
stem
cells
(MuSCs).
By
deleting
Paxbp1
quiescent
MuSCs,
we
found
that
-null
MuSCs
were
unable
to
reenter
cell
cycle
proliferate
upon
injury
and
subsequently
underwent
apoptosis,
resulting
total
failure
injury-induced
regeneration.
Mechanistically,
controls
late
cell-growth
checkpoint
by
targeting
mTORC1.
Loss
led
increased
levels
reactive
oxygen
species
turn
triggered
p53
activation
induction
multiple
target
genes,
some
which
contributed
cell-cycle
arrest
(e.g.,
Cdkn1a
),
apoptosis
Apaf1
impaired
mTORC1
signaling
Sesn2
Ddit4
).
Antioxidants and Redox Signaling,
Journal Year:
2020,
Volume and Issue:
34(4), P. 294 - 307
Published: March 31, 2020
Significance:
Senescence
is
a
cellular
state
induced
by
internal
or
external
stimuli,
which
result
in
cell
cycle
arrest,
morphological
changes,
and
dysfunctions
mitochondrial
lysosomal
functionality
as
well
the
senescence-associated
secretory
phenotype.
Senescent
cells
accumulate
tissues
physiological
pathological
conditions
such
development,
tissue
repair,
aging,
cancer.
Recent
Advances:
Growing
evidences
indicate
that
senescent
vivo
are
heterogeneous
population
due
to
different
cell-autonomous
activated
pathways
distinct
microenvironmental
contexts.
Critical
Issues:
In
this
review,
we
discuss
contexts
where
senescence
assumes
key
role
with
beneficial
harmful
outcomes.
The
nature
of
pushes
toward
resolution
specific
molecular
profile
secretome
typify
Future
Directions:
research
will
enable
exploring
heterogeneity
precisely
map
progression
through
trajectories
study
impact
therapeutic
advantage
senolytic
drugs
for
translational
strategies
supporting
health
span.
Antioxid.
Redox
Signal.
34,
294–307.
The Journal of Physiology,
Journal Year:
2022,
Volume and Issue:
601(22), P. 5011 - 5031
Published: March 23, 2022
Extended
periods
of
bed
rest
and
limb
immobilization
are
required
for
healing
post-injury
or
disease,
yet
disuse
can
result
in
significant
muscle
atrophy
decreased
quality
life
older
adults.
Physical
rehabilitation
is
commonly
prescribed
to
recover
these
deficits,
accumulation
reactive
oxygen
species
sustained
rates
protein
degradation
persist
during
the
period
that
significantly
delay
prevent
recovery.
Pericytes,
considered
primary
mesenchymal
vascular
stromal
cell
skeletal
muscle,
secrete
beneficial
factors
maintain
baseline
mass,
minimal
information
exists
regarding
pericyte
response
In
current
study,
single-cell
RNA
sequencing
functional
assays
were
performed
demonstrate
pericytes
mouse
lose
capacity
synthesize
antioxidants
This
was
used
guide
design
a
strategy
which
healthy
donor
stimulated
with
hydrogen
peroxide
(H
