NIH Music-Based Intervention Toolkit

Neurology, Journal Year: 2023, Volume and Issue: 100(18), P. 868 - 878

Published: Jan. 14, 2023

Music-based interventions (MBIs) show promise for managing symptoms of various brain disorders. To fully realize the potential MBIs and dispel outdated misconception that are rooted in soft science, NIH is promoting rigorously designed, well-powered MBI clinical trials. The pressing need guidelines scientifically rigorous studies with enhanced data collection brought together Renée Fleming Foundation, Foundation NIH, Trans-NIH Music Health Working Group, an interdisciplinary scientific expert panel to create Toolkit research on music health across lifespan. defines building blocks MBIs, including a consolidated set common elements protocols, core datasets outcome measures biomarkers disorders aging researchers may select their studies. Utilization guiding principles this will be strongly recommended NIH-funded MBIs.

Language: Английский

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Continuous speech processing

Current Opinion in Physiology, Journal Year: 2020, Volume and Issue: 18, P. 25 - 31

Published: July 28, 2020

Language: Английский

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Neural generators of the frequency-following response elicited to stimuli of low and high frequency: A magnetoencephalographic (MEG) study

NeuroImage, Journal Year: 2021, Volume and Issue: 231, P. 117866 - 117866

Published: Feb. 15, 2021

The frequency-following response (FFR) to periodic complex sounds has gained recent interest in auditory cognitive neuroscience as it captures with great fidelity the tracking accuracy of sound features ascending system. Seminal studies suggested FFR a correlate subcortical encoding, yet aiming locate its sources challenged this assumption, demonstrating that receives some contribution from cortex. Based on frequency-specific phase-locking capabilities along hierarchy, we hypothesized FFRs higher frequencies would receive less cortical than those lower frequencies, hence supporting major involvement for these high frequency sounds. Here, used magnetoencephalographic (MEG) approach trace neural elicited healthy adults (N = 19) low (89 Hz) and (333 were clearly observable MEG comparable obtained simultaneous electroencephalographic recordings. Distributed source modeling analyses revealed midbrain, thalamic, contributions FFR, arranged configurations. Our results showed main high-frequency originated inferior colliculus medial geniculate body thalamus, no significant contribution. In contrast, low-frequency had located cortices, also received originating midbrain thalamic structures. These findings support multiple generator hypothesis are relevant our understanding encoding suggesting hierarchical organization periodicity encoding.

Language: Английский

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Short- and long-term neuroplasticity interact during the perceptual learning of concurrent speech

Cerebral Cortex, Journal Year: 2024, Volume and Issue: 34(2)

Published: Jan. 11, 2024

Abstract Plasticity from auditory experience shapes the brain’s encoding and perception of sound. However, whether such long-term plasticity alters trajectory short-term during speech processing has yet to be investigated. Here, we explored neural mechanisms interplay between short- neuroplasticity for rapid perceptual learning concurrent sounds in young, normal-hearing musicians nonmusicians. Participants learned identify double-vowel mixtures ~ 45 min training sessions recorded simultaneously with high-density electroencephalography (EEG). We analyzed frequency-following responses (FFRs) event-related potentials (ERPs) investigate correlates at subcortical cortical levels, respectively. Although both groups showed learning, faster behavioral decisions than nonmusicians overall. Learning-related changes were not apparent brainstem FFRs. was highly evident cortex, where ERPs revealed unique hemispheric asymmetries suggestive different strategies (musicians: right hemisphere bias; nonmusicians: left hemisphere). Source reconstruction early (150–200 ms) time course these effects localized learning-induced auditory-sensory brain areas. Our findings reinforce domain-general benefits musicianship but reveal that successful sound is driven by a critical long- plasticity, which first emerge level.

Language: Английский

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Attention reinforces human corticofugal system to aid speech perception in noise

NeuroImage, Journal Year: 2021, Volume and Issue: 235, P. 118014 - 118014

Published: March 30, 2021

Perceiving speech-in-noise (SIN) demands precise neural coding between brainstem and cortical levels of the hearing system. Attentional processes can then select prioritize task-relevant cues over competing background noise for successful speech perception. In animal models, brainstem-cortical interplay is achieved via descending corticofugal projections from cortex that shape midbrain responses to behaviorally-relevant sounds. engagement feedback may assist SIN understanding but has never been confirmed remains highly controversial in humans. To resolve these issues, we recorded source-level, anatomically constrained frequency-following (FFRs) event-related potentials (ERPs) high-density EEG while listeners performed rapid identification tasks. We varied attention with active vs. passive listening scenarios whereas task difficulty was manipulated additive interference. Active (but not arousal-control tasks) exaggerated both ERPs FFRs, confirming attentional gain extends lower subcortical processing. used functional connectivity measure directed strength coupling characterize "bottom-up" "top-down" (corticofugal) signaling within auditory pathway. While strengthened bidirectionally, transmission disengaged under active) listening. Our findings (i) show enhances brain's transcription even prior (ii) establish a direct role human system as an aid cocktail party

Language: Английский

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Oscillatory Entrainment of the Frequency-following Response in Auditory Cortical and Subcortical Structures

Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 41(18), P. 4073 - 4087

Published: March 17, 2021

There is much debate about the existence and function of neural oscillatory mechanisms in auditory system. The frequency-following response (FFR) an index periodicity encoding that can provide a vehicle to study entrainment frequency ranges relevant speech music processing. Criteria for include presence poststimulus oscillations phase alignment between stimulus endogenous activity. To test hypothesis entrainment, experiment 1 we collected FFR data repeated syllable using magnetoencephalography (MEG) electroencephalography 20 male female human adults. We observed significant activity after offset cortex subcortical nuclei, consistent with entrainment. In these structures, fundamental converged from lower value over 100 ms frequency, alignment, diverged offset, relaxation preferred frequency. 2, tested how transitions frequencies affected MEG train tone pairs 30 people. found was by preceding up 40 at levels, even longer durations cortical levels. Our results suggest may be integral part periodic sound representation throughout neuraxis. functional role this mechanism unknown, but it could serve as fine-scale temporal predictor information, enhancing stability reducing susceptibility degradation useful real-life noisy environments. SIGNIFICANCE STATEMENT Neural are proposed ubiquitous aspect function, their contribution not clear, particularly higher associated pitch encoding. experiment, converging evidence has component according established criteria: resonance, progressive toward original state on offset. second amplitude tones stimuli. These findings support intrinsic sound, raise new questions roles, possibly including stabilization low-level predictive coding.

Language: Английский

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Challenges and Approaches in the Study of Neural Entrainment

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(40), P. e1234242024 - e1234242024

Published: Oct. 2, 2024

When exposed to rhythmic stimulation, the human brain displays activity across sensory modalities and regions. Given ubiquity of this phenomenon, how rhythms are transformed into neural remains surprisingly inconclusive. An influential model posits that endogenous oscillations entrain external rhythms, thereby encoding environmental dynamics shaping perception. However, research on entrainment faces multiple challenges, from ambiguous definitions methodological difficulties when need be identified disentangled other stimulus-related mechanisms can lead similar phase-locked responses. Yet, recent years have seen novel approaches overcome these including computational modeling, insights dynamical systems theory, sophisticated stimulus designs, study neuropsychological impairments. This review outlines key challenges in research, delineates state-of-the-art approaches, integrates findings animal neurophysiology provide a broad perspective usefulness, validity, constraints oscillatory models brain-environment interaction.

Language: Английский

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Neural tracking of the fundamental frequency of the voice: The effect of voice characteristics

European Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 53(11), P. 3640 - 3653

Published: April 17, 2021

Abstract Traditional electrophysiological methods to study temporal auditory processing of the fundamental frequency voice (f0) often use unnaturally repetitive stimuli. In this study, we investigated f0 meaningful continuous speech. EEG responses evoked by stories in quiet were analysed with a novel method based on linear modelling that characterizes neural tracking f0. We studied both strength and spatio‐temporal properties f0‐tracking response. Moreover, different samples speech (six four speakers: two male female) used investigate effect characteristics The results indicated response is inversely related rate change throughout story. As result, male‐narrated (low steady f0) stronger compared female‐narrated (high variable f0), for which many not significant. analysis revealed generators fixed brainstem but voice‐dependent as well. Voices high subcortically dominated latency between 7 12 ms. low are (latency 13–15 ms) cortically 23–26 generated, right primary cortex likely cortical source. Finally, additional experiments greatly improves voices strong higher harmonics, particularly useful boost small

Language: Английский

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The Early Subcortical Response at the Fundamental Frequency of Speech Is Temporally Separated from Later Cortical Contributions

Journal of Cognitive Neuroscience, Journal Year: 2024, Volume and Issue: 36(3), P. 475 - 491

Published: Jan. 1, 2024

Abstract Most parts of speech are voiced, exhibiting a degree periodicity with fundamental frequency and many higher harmonics. Some neural populations respond to this temporal fine structure, in particular at the frequency. This frequency-following response consists both subcortical cortical contributions can be measured through EEG as well magnetoencephalography (MEG), although differ aspects activity that they capture: is sensitive radial tangential sources deep sources, whereas MEG more restrained measurement superficial activity. responses continuous have shown an early contribution, latency around 9 msec, agreement measurements short tokens, not yet revealed such component. Here, we analyze long segments speech. We find latencies 4–11 followed by later right-lateralized activities delays 20–58 msec potential activities. Our results show component FFR from participants its agrees EEG. They furthermore temporally separated contributions, enabling independent assessment components toward further processing.

Language: Английский

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From Perception to Pleasure

Oxford University Press eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 23, 2023

Abstract How does perception of abstract tonal patterns—music—lead to the pleasure we experience from these sounds? The answer presented in this book is that music arises interactions between cortical loops enable processing sound patterns and subcortical circuits responsible for reward valuation. auditory cortex its ventral-stream connections encode acoustical features their relationships, maintain them working memory, form internal representations statistical which predictions are made about how evolve time. Disruption pathway leads amusia. dorsal stream allows sensory-motor transformations, production, metrical representation, leading when events will occur. These predictive processes play a central role creating expectancies musical transmitted dopaminergic system, where hedonic responses generated according well an event fits with predictions. linked balance predictability surprise patterns. perceptual systems anhedonia. Engagement system also related movement vocal cues, social factors, preference, emotion regulation.

Language: Английский

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