miRNA signatures associated with vulnerability to food addiction in mice and humans DOI Creative Commons
Alejandra García‐Blanco, Laura Domingo‐Rodriguez, Judit Cabana‐Domínguez

et al.

Journal of Clinical Investigation, Journal Year: 2022, Volume and Issue: 132(10)

Published: March 29, 2022

Food addiction is characterized by a loss of behavioral control over food intake and associated with obesity other eating disorders. The mechanisms underlying this disorder are largely unknown. We aimed to investigate the changes in miRNA expression promoted animals humans their involvement hallmarks disorder. found sharp similitudes between signatures medial prefrontal cortex (mPFC) our animal cohort circulating levels human cohort, which allowed us identify several miRNAs potential interest development Tough decoy (TuD) inhibition miRNA-29c-3p mouse mPFC persistence response enhanced vulnerability developing addiction, whereas miRNA-665-3p compulsion-like behavior also vulnerability. In contrast, we that miRNA-137-3p did not lead addiction. Therefore, could be acting as protective factors regard believe elucidation these epigenetic will advances toward identifying innovative biomarkers possible future interventions for related disorders based on strategies now available modify activity expression.

Language: Английский

Psychedelics and Other Psychoplastogens for Treating Mental Illness DOI Creative Commons
Maxemiliano V. Vargas, Retsina Meyer, Arabo A. Avanes

et al.

Frontiers in Psychiatry, Journal Year: 2021, Volume and Issue: 12

Published: Oct. 4, 2021

Psychedelics have inspired new hope for treating brain disorders, as they seem to be unlike any treatments currently available. Not only do produce sustained therapeutic effects following a single administration, also appear broad potential, demonstrating efficacy depression, post-traumatic stress disorder (PTSD), anxiety substance abuse disorder, and alcohol use among others. belong more general class of compounds known psychoplastogens, which robustly promote structural functional neural plasticity in key circuits relevant health. Here we discuss the importance treatment neuropsychiatric diseases, well evidence that psychedelics are most effective chemical modulators studied date. Furthermore, provide theoretical framework with potential explain why psychedelic long-lasting across wide range disorders. Despite their promise broadly efficacious neurotherapeutics, there several issues associated psychedelic-based medicines drastically limit clinical scalability. We these challenges how might overcome through development non-hallucinogenic psychoplastogens. The other psychoplastogenic marks paradigm shift neuropsychiatry toward approaches relying on selective modulation small molecule drugs. Psychoplastogen research brings us one step closer actually curing mental illness by rectifying underlying pathophysiology disorders like moving beyond simply disease symptoms. However, determining effectively deploy at scale will an important consideration field moves forward.

Language: Английский

Citations

116
Gut microbiota signatures of vulnerability to food addiction in mice and humans DOI Creative Commons
S. Samulenaite, Alejandra García‐Blanco, Jordi Mayneris‐Perxachs

et al.

Gut, Journal Year: 2024, Volume and Issue: 73(11), P. 1799 - 1815

Published: June 26, 2024

Food addiction is a multifactorial disorder characterised by loss of control over food intake that may promote obesity and alter gut microbiota composition. We have investigated the potential involvement in mechanisms underlying addiction.

Language: Английский

Citations

11
The nucleus accumbens in reward and aversion processing: insights and implications DOI Creative Commons
Ying Xu, Yingjie Lin, Ming Yu

et al.

Frontiers in Behavioral Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 9, 2024

The nucleus accumbens (NAc), a central component of the brain's reward circuitry, has been implicated in wide range behaviors and emotional states. Emerging evidence, primarily drawing from recent rodent studies, suggests that function NAc aversion processing is multifaceted. Prolonged stress or drug use induces maladaptive neuronal which results pathological conditions. This review aims to provide comprehensive up-to-date insights on role motivated behavior regulation highlights areas demand further in-depth analysis. It synthesizes latest findings how distinct populations pathways contribute opposite valences. examines neuromodulators, especially monoamines, influence NAc's control over various motivational Furthermore, it delves into complex underlying mechanisms psychiatric disorders such as addiction depression evaluates prospective interventions restore functionality.

Language: Английский

Citations

9
Binge eating, overeating and food addiction: Approaches for examining food overconsumption in laboratory rodents DOI Creative Commons
Robyn M. Brown, Morgan H. James

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2023, Volume and Issue: 123, P. 110717 - 110717

Published: Jan. 6, 2023

Language: Английский

Citations

20
Whole-brain tracking of cocaine and sugar rewards processing DOI Creative Commons
Łukasz Bijoch, Joanna Klos, Monika Pawłowska

et al.

Translational Psychiatry, Journal Year: 2023, Volume and Issue: 13(1)

Published: Jan. 23, 2023

Abstract Natural rewards, such as food, and sex are appetitive stimuli available for animals in their natural environment. Similarly, addictive rewards drugs of abuse possess strong, positive valence, but action relies on pharmacological properties. Nevertheless, it is believed that both these kinds activate similar brain circuitry. The present study aimed to discover which parts the process experience rewards. To holistically address this question, we used a single-cell whole-brain imaging approach find patterns activation acute prolonged sucrose cocaine exposure. We analyzed almost 400 structures created brain-wide map specific, c-Fos-positive neurons engaged by Acute not exposure triggered massive c-Fos expression throughout brain. Cocaine other hand potentiated with use, engaging more than treatment. functional connectivity analysis unraveled an increase modularity after initial types This was increased repeated cocaine, sucrose, intake. check whether discrepancies between processing can be found cellular level, further studied nucleus accumbens, one most strongly activated experience. high overlap level expression. Electrophysiological measurements correlates synaptic plasticity revealed alike induce accumulation silent synapses. These results strengthen hypothesis accumbens cause maladaptive neuronal circuitry typically processes

Language: Английский

Citations

17
Suppression of Corticostriatal Circuit Activity Improves Cognitive Flexibility and Prevents Body Weight Loss in Activity-Based Anorexia in Rats DOI
Laura K Milton, Paul N. Mirabella,

Erika Greaves

et al.

Biological Psychiatry, Journal Year: 2020, Volume and Issue: 90(12), P. 819 - 828

Published: July 2, 2020

Language: Английский

Citations

45
Food craving-like episodes during pregnancy are mediated by accumbal dopaminergic circuits DOI
Roberta Haddad-Tóvolli, Sara Ramírez, Emma Muñoz‐Moreno

et al.

Nature Metabolism, Journal Year: 2022, Volume and Issue: 4(4), P. 424 - 434

Published: April 4, 2022

Language: Английский

Citations

24
Corticostriatal Activity Driving Compulsive Reward Seeking DOI Creative Commons
Masaya Harada, Vincent Pascoli,

Agnès Hiver

et al.

Biological Psychiatry, Journal Year: 2021, Volume and Issue: 90(12), P. 808 - 818

Published: Sept. 2, 2021

Activation of the mesolimbic dopamine system is positively reinforcing. After repeated activation, some individuals develop compulsive reward-seeking behavior, which a core symptom addiction. However, underlying neural mechanism remains elusive.We trained mice in seek-take chain, rewarded by optogenetic neuron self-stimulation. compulsivity was evaluated, AMPA/NMDA ratio measured at three distinct corticostriatal pathways confirmed retrograde labeling and anterograde synaptic connectivity. Fiber photometry method chemogenetics were used to parse contribution orbitofrontal cortex afferents onto dorsal striatum (DS) during behavioral task. We established causal link between DS activity using inhibition.Mice that persevered when seeking punished exhibited an increased selectively synapses. In addition, peak spiny projection neurons moment signaled reward availability detected. Chemogenetic inhibition curbed reduced seeking, as did hyperpolarization time-locked cue predicting availability.Our results suggest display stronger neuronal even risk punishment, nurturing further seeking.

Language: Английский

Citations

32
The Role of the Endocannabinoid System in Binge Eating Disorder DOI Open Access

Romain Bourdy,

Katia Befort

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9574 - 9574

Published: May 31, 2023

Eating disorders are multifactorial that involve maladaptive feeding behaviors. Binge eating disorder (BED), the most prevalent of these in both men and women, is characterized by recurrent episodes large amounts food a short period time, with subjective loss control over behavior. BED modulates brain reward circuit humans animal models, which involves dynamic regulation dopamine circuitry. The endocannabinoid system plays major role intake, centrally periphery. Pharmacological approaches together research using genetically modified animals have strongly highlighted predominant behaviors, specific modulation addictive-like purpose present review to summarize our current knowledge on neurobiology models highlight development maintenance BED. A proposed model for better understanding underlying mechanisms involving discussed. Future will be necessary develop more treatment strategies reduce symptoms.

Language: Английский

Citations

11
The ion channel TRPA1 is a modulator of the cocaine reward circuit in the nucleus accumbens DOI Creative Commons

Young-Jung Kim,

Su Jeong Choi,

Sa-Ik Hong

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(11), P. 3607 - 3622

Published: May 31, 2024

Abstract Drug addiction therapies commonly fail because continued drug use promotes the release of excessive and pleasurable dopamine levels. Because connection between pleasure becomes hard-wired in nucleus accumbens (NAc), which interfaces motivation, effective need to modulate this mesolimbic reward system. Here, we report that mice with knockdown cation channel TRPA1 (transient receptor potential ankyrin 1) were resistant drug-seeking behavior effects cocaine compared their wildtype litter mates. In our study, demonstrate inhibition NAc reduces activity release, conversely, is critical for cocaine-induced synaptic strength 1-expressing medium spiny neurons. Taken together, data support reward-related are controlled by suggest has therapeutic as a target misuse therapies.

Language: Английский

Citations

4