Interplay between gut microbiome, host genetic and epigenetic modifications in MASLD and MASLD-related hepatocellular carcinoma

Gut, Journal Year: 2024, Volume and Issue: 74(1), P. 141 - 152

Published: June 29, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a wide spectrum of injuries, ranging from hepatic steatosis, metabolic steatohepatitis (MASH), fibrosis, cirrhosis to MASLD-associated hepatocellular carcinoma (MASLD-HCC). Recent studies have highlighted the bidirectional impacts between host genetics/epigenetics and gut microbial community. Host genetics influence composition microbiome, while microbiota their derived metabolites can induce epigenetic modifications affect development MASLD. The exploration intricate relationship microbiome genetic/epigenetic makeup is anticipated yield promising avenues for therapeutic interventions targeting MASLD its associated conditions. In this review, we summarise effects alterations in MASLD-HCC. We further discuss research findings demonstrating genetics/epigenetics, emphasising significance interconnection prevention treatment.

Language: Английский

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Chronic arsenic exposure-provoked biotoxicity involved in liver-microbiota-gut axis disruption in chickens based on multi-omics technologies

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Arsenic has been ranked as the most hazardous substance by U.S. Agency for Toxic Substances and Disease Registry. Environmental arsenic exposure-evoked health risks have become a vital public concern worldwide owing to widespread existence of arsenic. Multi-omics is revolutionary technique data analysis providing an integrated view bioinformation comprehensively systematically understanding elaborate mechanism diseases. This study aimed at uncovering potential contribution liver-microbiota-gut axis in chronic inorganic exposure-triggered biotoxicity chickens based on multi-omics technologies. Forty Hy-Line W-80 laying hens were chronically exposed sodium arsenite with dose-dependent manner (administered drinking water containing 10, 20, or 30 mg/L arsenic, respectively) 42 d, followed transcriptomics, serum non-targeted metabolome, 16S ribosomal RNA gene sequencing accordingly. intervention induced serious chicken liver dysfunction, especially severe fibrosis, simultaneously altered ileal microbiota populations, impaired intestinal barrier, further drove enterogenous lipopolysaccharides translocation via portal vein circulation aggravating damage. Furtherly, injured disturbed bile acids (BAs) homoeostasis through strongly up-regulating BAs synthesis key rate-limiting enzyme CYP7A1, inducing excessive total accumulation, accompanied massive primary BA—chenodeoxycholic acid. Moreover, concentrations secondary BAs—ursodeoxycholic acid lithocholic markedly repressed, which might involve repressed dehydroxylation Ruminococcaceae Lachnospiraceae families. Abnormal metabolism turn promoted injury, ultimately perpetuating pernicious circle chickens. Notably, obvious depletion abundance four profitable microbiota, Christensenellaceae, Ruminococcaceae, Muribaculaceae, Faecalibacterium, correlated tightly this hepato-intestinal process Our demonstrates that exposure evokes disruption establishes scientific basis evaluating risk environmental pollutant

Language: Английский

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The association between the dietary index for gut microbiota and metabolic dysfunction-associated fatty liver disease: a cross-sectional study

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 17, 2025

The relationship between the gut microbiome and metabolic dysfunction-associated fatty liver disease (MAFLD) has garnered increasing attention. However, association dietary index for microbiota (DI-GM), a measure of diversity, MAFLD yet to be fully explored. Data from 2017-2020 National Health Nutrition Examination Survey (NHANES) were analyzed, including 7243 participants. DI-GM was investigated using weighted logistic regression, restricted cubic spline (RCS), subgroup analyses. A notable inverse identified prevalence MAFLD, with each 1-point increase in corresponding 6.1% reduction (OR = 0.939, 95% CI: 0.901-0.980). Individuals score 6 or higher had an adjusted OR 0.794 (95% 0.665-0.947) compared those 0-3. RCS analysis further revealed linear risk. Additionally, analyses suggested that race may modify (P interaction < 0.05). is inversely associated prevalence, appears significant modifier this relationship.

Language: Английский

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Lactobacillus lactis and Pediococcus pentosaceus‐driven reprogramming of gut microbiome and metabolome ameliorates the progression of non‐alcoholic fatty liver disease

Clinical and Translational Medicine, Journal Year: 2021, Volume and Issue: 11(12)

Published: Dec. 1, 2021

Language: Английский

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Intestinal dysbiosis in nonalcoholic fatty liver disease (NAFLD): focusing on the gut–liver axis

Critical Reviews in Food Science and Nutrition, Journal Year: 2021, Volume and Issue: 63(12), P. 1689 - 1706

Published: Aug. 18, 2021

Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic disorders in humans, partly because it closely related to metabolic with increasing prevalence. NAFLD begins hepatic lipid accumulation, which may cause inflammation and eventually lead fibrosis liver. Numerous studies have demonstrated close relationship between gut dysfunction (especially microbiota its metabolites) occurrence progression NAFLD. The bidirectional communication liver, named gut-liver axis, mainly mediated by metabolites derived from both through biliary tract, portal vein, systemic circulation. Herein, we review effects axis on pathogenesis We also comprehensively describe potential molecular mechanisms perspective role liver-derived gut-related components metabolism health, respectively. study provides insights into underlying current summarizations that support intricate interactions a disordered can provide novel strategies lessen prevalence consequence

Language: Английский

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