Hepatology,
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 10, 2023
Liver
cancer,
primarily
HCC,
exhibits
highly
heterogeneous
histological
and
molecular
aberrations
across
tumors
within
individual
tumor
nodules.
Such
intertumor
intratumor
heterogeneities
may
lead
to
diversity
in
the
natural
history
of
disease
progression
various
clinical
disparities
patients.
Recently
developed
multimodality,
single-cell,
spatial
omics
profiling
technologies
have
enabled
interrogation
intertumor/intratumor
heterogeneity
cancer
cells
immune
microenvironment.
These
features
influence
efficacy
emerging
therapies
targeting
novel
pathways,
some
which
had
been
deemed
undruggable.
Thus,
comprehensive
characterization
at
levels
facilitate
discovery
biomarkers
that
enable
personalized
rational
treatment
decisions,
optimize
while
minimizing
risk
adverse
effects.
companion
will
also
refine
HCC
algorithms
stages
for
cost-effective
patient
management
by
optimizing
allocation
limited
medical
resources.
Despite
this
promise,
complexity
ever-expanding
inventory
therapeutic
agents
regimens
made
evaluation
translation
increasingly
challenging.
To
address
issue,
trial
designs
proposed
incorporated
into
recent
studies.
In
review,
we
discuss
latest
findings
landscape
their
potential
utility
as
biomarkers,
framework
application
predictive/prognostic
ongoing
biomarker-guided
trials.
new
developments
revolutionize
care
substantially
impact
still
dismal
mortality.
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2024,
Volume and Issue:
43(1)
Published: Feb. 2, 2024
Abstract
Tumor-infiltrating
T
cells
recognize,
attack,
and
clear
tumor
cells,
playing
a
central
role
in
antitumor
immune
response.
However,
certain
can
impair
this
response
help
escape.
Therefore,
exploring
the
factors
that
influence
T-cell
infiltration
is
crucial
to
understand
immunity
improve
therapeutic
effect
of
cancer
immunotherapy.
The
use
single-cell
RNA
sequencing
(scRNA-seq)
allows
high-resolution
analysis
precise
composition
with
different
phenotypes
other
microenvironmental
factors,
including
non-immune
stromal
related
molecules
microenvironment
various
types.
In
review,
we
summarized
research
progress
on
crosstalk
cytokines
during
using
scRNA-seq
provide
insights
into
mechanisms
regulating
contribute
new
perspectives
Hepatology,
Journal Year:
2022,
Volume and Issue:
75(4), P. 1038 - 1049
Published: Jan. 13, 2022
Abstract
In
association
with
the
pandemic
spreading
of
obesity
and
metabolic
syndrome,
prevalence
NAFLD‐related
HCC
is
increasing
almost
exponentially.
recent
years,
many
underlining
multifactorial
causes
NAFLD
have
been
identified,
cellular
mechanisms
sustaining
disease
development
dissected
up
to
single‐cell
level.
However,
there
still
an
urgent
need
provide
clinicians
more
therapeutic
targets,
particular
attention
on
NAFLD‐induced
HCC,
where
immune
checkpoint
inhibitors
do
not
work
as
efficiently.
Whereas
much
effort
has
invested
in
elucidating
role
innate
response
hepatic
microenvironment,
only
past
decade
novel
critical
roles
unraveled
for
T
cells
driving
chronic
inflammation
toward
HCC.
The
microenvironment
interact
recreate
a
tumor‐promoting
immune‐suppressive
terrain,
responsible
resistance
anticancer
therapy.
this
article,
we
will
review
specific
functions
several
T‐cell
populations
involved
NAFLD‐driven
We
illustrate
crosstalk
other
cells,
regulatory
networks
or
stimulatory
effects
these
interactions,
influencing
cell
functionality.
Finally,
present
pros
cons
current
strategies
against
delineate
possible
approaches
future.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Sept. 11, 2023
Male
breast
cancer
(MBC)
is
a
rare
but
aggressive
malignancy
with
cellular
and
immunological
characteristics
that
remain
unclear.
Here,
we
perform
transcriptomic
analysis
for
111,038
single
cells
from
tumor
tissues
of
six
MBC
thirteen
female
(FBC)
patients.
We
find
has
significantly
lower
infiltration
T
relative
to
FBC.
Metastasis-related
programs
are
more
active
in
MBC.
The
activated
fatty
acid
metabolism
involved
FASN
related
cell
metastasis
low
immune
show
activation
p38
MAPK
lipid
oxidation
pathways,
indicating
dysfunctional
state.
In
contrast,
FBC
exhibit
higher
expression
cytotoxic
markers
pathways
mediated
by
immune-modulatory
cytokines.
Moreover,
identify
the
inhibitory
interactions
between
Our
study
provides
important
information
understanding
immunology
Protein & Cell,
Journal Year:
2023,
Volume and Issue:
15(2), P. 98 - 120
Published: June 28, 2023
Aging
increases
the
risk
of
liver
diseases
and
systemic
susceptibility
to
aging-related
diseases.
However,
cell
type-specific
changes
underlying
mechanism
aging
in
higher
vertebrates
remain
incompletely
characterized.
Here,
we
constructed
first
single-nucleus
transcriptomic
landscape
primate
aging,
which
resolved
gene
expression
fluctuation
hepatocytes
across
three
zonations
detected
aberrant
cell-cell
interactions
between
niche
cells.
Upon
in-depth
dissection
this
rich
dataset,
identified
impaired
lipid
metabolism
upregulation
chronic
inflammation-related
genes
prominently
associated
with
declined
functions
during
aging.
In
particular,
hyperactivated
sterol
regulatory
element-binding
protein
(SREBP)
signaling
was
a
hallmark
aged
liver,
consequently,
forced
activation
SREBP2
human
primary
recapitulated
vivo
phenotypes,
manifesting
as
detoxification
accelerated
cellular
senescence.
This
study
expands
our
knowledge
informs
development
diagnostics
therapeutic
interventions
for
