Loss of transcriptional plasticity but sustained adaptive capacity after adaptation to global change conditions in a marine copepod

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: March 3, 2022

Abstract Adaptive evolution and phenotypic plasticity will fuel resilience in the geologically unprecedented warming acidification of earth’s oceans, however, we have much to learn about interactions costs these mechanisms resilience. Here, using 20 generations experimental followed by three reciprocal transplants, investigated relationship between adaptation marine copepod, Acartia tonsa , future global change conditions (high temperature high CO 2 ). We found parallel genes related stress response, gene expression regulation, actin developmental processes, energy production. However, transplantation showed that resulted a loss transcriptional plasticity, reduced fecundity, population growth when change-adapted animals were returned ambient or reared low food conditions. after successive transplant generations, able match ambient-adaptive profile. Concurrent changes allele frequencies erosion nucleotide diversity suggest this recovery occurred via back ancestral These results demonstrate while facilitated initial survival conditions, it eroded as populations adapted, limiting new stressors previously benign environments.

Language: Английский

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A global meta‐analysis reveals higher variation in breeding phenology in urban birds than in their non‐urban neighbours

Ecology Letters, Journal Year: 2022, Volume and Issue: 25(11), P. 2552 - 2570

Published: Sept. 22, 2022

Cities pose a major ecological challenge for wildlife worldwide. Phenotypic variation, which can result from underlying genetic variation or plasticity, is an important metric to understand eco-evolutionary responses environmental change. Recent work suggests that urban populations might have higher levels of phenotypic than non-urban counterparts. This prediction, however, has never been tested across species nor over broad geographical range. Here, we conducted meta-analysis the avian literature compare versus means and in phenology (i.e. lay date) reproductive effort clutch size, number fledglings). First, show reproduce earlier smaller broods conspecifics. Second, laying date populations. arises differences between within breeding seasons, conceivably due landscape heterogeneity habitats. These findings reveal novel effect urbanisation on animal life histories with potential implications adaptation environments (which will require further investigation). The birds subjected disturbance could plastic heterogeneous environment, phenology, possibly linked evolutionary potential.

Language: Английский

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The evolution of plasticity at geographic range edges

Trends in Ecology & Evolution, Journal Year: 2023, Volume and Issue: 38(9), P. 831 - 842

Published: May 12, 2023

Language: Английский

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Learning to predict RNA sequence expressions from whole slide images with applications for search and classification

Communications Biology, Journal Year: 2023, Volume and Issue: 6(1)

Published: March 22, 2023

Deep learning methods are widely applied in digital pathology to address clinical challenges such as prognosis and diagnosis. As one of the most recent applications, deep models have also been used extract molecular features from whole slide images. Although tests carry rich information, they often expensive, time-consuming, require additional tissue sample. In this paper, we propose tRNAsformer, an attention-based topology that can learn both predict bulk RNA-seq image represent a glass simultaneously. The tRNAsformer uses multiple instance solve weakly supervised problem while pixel-level annotation is not available for image. We conducted several experiments achieved better performance faster convergence comparison state-of-the-art algorithms. proposed assist computational tool facilitate new generation search classification by combining morphology fingerprint biopsy samples.

Language: Английский

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Toward Accurate Photoluminescence Nanothermometry Using Rare-Earth Doped Nanoparticles for Biomedical Applications

Accounts of Chemical Research, Journal Year: 2024, Volume and Issue: 57(18), P. 2653 - 2664

Published: Aug. 28, 2024

ConspectusPhotoluminescence nanothermometry can detect the local temperature at submicrometer scale with minimal contact object under investigation. Owing to its high spatial resolution, this technique shows great potential in biomedicine both fundamental studies as well preclinical research. Photoluminescence exploits temperature-dependent optical properties of various nanoscale probes including organic fluorophores, quantum dots, and carbon nanostructures. At vanguard these diverse probes, rare-earth doped nanoparticles (RENPs) have demonstrated remarkable capabilities photoluminescence nanothermometry. They distinguish themselves from other luminescent nanoprobes owning their unparalleled versatile that include narrow emission bandwidths, photostability, tunable lifetimes microseconds milliseconds, multicolor emissions spanning ultraviolet, visible, near-infrared (NIR) regions, ability undergo upconversion, all excitation a single, biologically friendly NIR wavelength. Recent advancements design novel RENPs led new breakthroughs Moreover, driven by excellent biocompatibility,

Language: Английский

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Environmentally robust cis -regulatory changes underlie rapid climatic adaptation

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(39)

Published: Sept. 19, 2023

Changes in gene expression are thought to play a major role adaptive evolution. While it is known that highly sensitive the environment, very few studies have determined influence of genetic and environmental effects on differences natural populations. Here, we utilize allele-specific characterize cis trans regulatory divergence temperate tropical house mice two metabolic tissues under thermal conditions. First, show pervasive between populations across conditions, with roughly 5 10% genes exhibiting genotype-by-environment interactions. Second, found most was due cis-regulatory changes were stable temperatures. In contrast, patterns plasticity largely attributable trans-effects, which showed greater sensitivity temperature. Nonetheless, small subset temperature-dependent changes, thereby identifying loci underlying plasticity. Finally, performed scans for selection wild identify genomic signatures rapid adaptation. Genomic outliers enriched evidence divergence. Notably, these associated phenotypes affected body weight metabolism, suggesting possible mechanism size evolution Our results plasticity, controlled trans, may facilitate colonization new environments, but evolved cis, illustrating nongenetic mechanisms establishment environments.

Language: Английский

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Urban evolutionary ecology brings exaptation back into focus

Trends in Ecology & Evolution, Journal Year: 2023, Volume and Issue: 38(8), P. 719 - 726

Published: April 4, 2023

Language: Английский

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Microhabitat level thermal physiology and thermoregulation of a diurnal gecko in an urban landscape

Frontiers in Amphibian and Reptile Science, Journal Year: 2025, Volume and Issue: 2

Published: Jan. 10, 2025

Urban areas comprise a matrix of natural and human-made microhabitats, with associated variation in microclimates. Since reptiles are dependent on environmental temperature for optimal functioning, their survival cities depends how well they can navigate microhabitat-level thermal heterogeneity. For the Mysore Day gecko ( Cnemaspis mysoriensis ) urban environment Bengaluru, we determined if shifts physiology or behavioural thermoregulatory strategies were used to adapt microhabitats (e.g. walls) compared (tree trunks roots). We collected active body temperatures field, measured preferred (T set ), tolerance limits (CT max CT min performance curve (TPC) locomotion lab. found that had slightly higher more variable than microhabitats. Thermal physiological variables , TPC) lizards caught from these distinct did not vary, implying conserved within species. However, given wild, seem be better quality, providing suitable range is closer Hence, spaces, thermoregulate accurately. demonstrate even small differences conditions at microhabitat scale influence accuracy thermoregulation city. Our result emphasise importance retaining habitats cityscape effective ectotherms, like C. .

Language: Английский

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Non‐lethal effects of climate change and infectious disease: An energetics approach to understanding population impacts

Functional Ecology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Climate change and infectious disease jointly impact species worldwide. In addition to causing conspicuous mortality events, these threats produce a range of non‐lethal effects that are often overlooked, yet can affect individual survival fecundity, ultimately, population viability. We develop an energetic framework structures the study climate their downstream demographic consequences. The identifies pathways by which acquisition, storage mobilisation energy required for organismal reproduction. joint disease, while non‐lethal, reduce fitness increasing demands, exacerbating trade‐offs accelerating physiological ageing. Considering mechanisms underlying explain when why recurrent and/or chronic events associated with be important limiting forces populations species. Read free Plain Language Summary this article on Journal blog.

Language: Английский

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Plastic responses to past environments shape adaptation to novel selection pressures

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(5)

Published: Jan. 30, 2025

Phenotypic plasticity may pave the way for rapid adaptation to newly encountered environments. Although it is often contested, there growing evidence that initial plastic responses of ancestral populations new environmental cues promote subsequent adaptation. However, we do not know whether present in habitat (past-cue plasticity) can facilitate novel cues. Conceivably, this could occur if are coincidentally optimal both past and (i.e., preadaptive) or they transferred during Past phenotype values also become fixed environment. To uncover role past-cue adaptation, tested gene expression two parallel mine-waste-adapted Silene uniflora their closest coastal relatives. Plants were exposed salt zinc, which revealed mine waste, diminishes. Despite this, our results show has a substantial impact on zinc. For third genes have evolved zinc populations, been response. Furthermore, quarter differences between similar responses. Alongside provide clear indication play key rapid, habitats.

Language: Английский

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