Days-old zebrafish rapidly learn to recognize threatening agents through noradrenergic and forebrain circuits DOI Creative Commons
Dhruv Zocchi, Mileena T. Nguyen, Emmanuel Márquez-Legorreta

et al.

Current Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Animals need to rapidly learn recognize and avoid predators. This ability may be especially important for young animals due their increased vulnerability. It is unknown whether, how, nascent vertebrates are capable of such rapid learning. Here, we used a robotic predator-prey interaction assay show that 1 week after fertilization-a developmental stage where they have approximately 1% the number neurons adults-zebrafish larvae robustly stationary object as threat pursues fish ∼1 min. Larvae continue threatening it stops moving can distinguish from non-threatening objects different color. Whole-brain functional imaging revealed multi-timescale activity noradrenergic forebrain circuits encoded threat. Chemogenetic ablation those populations prevented Thus, multiregional network underlies potential predators within first life.

Language: Английский

Visual recognition of social signals by a tectothalamic neural circuit DOI Creative Commons
Johannes M. Kappel, Dominique Förster, Katja Slangewal

et al.

Nature, Journal Year: 2022, Volume and Issue: 608(7921), P. 146 - 152

Published: July 13, 2022

Abstract Social affiliation emerges from individual-level behavioural rules that are driven by conspecific signals 1–5 . Long-distance attraction and short-distance repulsion, for example, jointly set a preferred interanimal distance in swarms 6–8 However, little is known about their perceptual mechanisms executive neural circuits 3 Here we trace the neuronal response to self-like biological motion 9,10 , visual trigger developing zebrafish 2,11 Unbiased activity mapping targeted volumetric two-photon calcium imaging revealed 21 hotspots distributed throughout brain as well clustered biological-motion-tuned neurons multimodal, socially activated nucleus of dorsal thalamus. Individual thalamus encode local acceleration stimuli mimicking typical fish kinetics but insensitive global or continuous motion. Electron microscopic reconstruction synaptic input optic tectum projections into hypothalamic areas with conserved social function 12–14 Ablation selectively disrupted without affecting repulsion. This tectothalamic pathway thus serves recognition conspecifics, dissociates control repulsion during affiliation, revealing circuit underpinning collective behaviour.

Language: Английский

Citations

59
Collective behavior from surprise minimization DOI Creative Commons
Conor Heins, Beren Millidge, Lancelot Da Costa

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(17)

Published: April 17, 2024

Collective motion is ubiquitous in nature; groups of animals, such as fish, birds, and ungulates appear to move a whole, exhibiting rich behavioral repertoire that ranges from directed movement milling disordered swarming. Typically, macroscopic patterns arise decentralized, local interactions among constituent components (e.g., individual fish school). Preeminent models this process describe individuals self-propelled particles, subject self-generated “social forces” short-range repulsion long-range attraction or alignment. However, organisms are not particles; they probabilistic decision-makers. Here, we introduce an approach modeling collective behavior based on active inference. This cognitive framework casts the consequence single imperative: minimize surprise. We demonstrate many empirically observed phenomena, including cohesion, milling, motion, emerge naturally when considering driven by Bayesian inference—without explicitly building rules goals into agents. Furthermore, show inference can recover generalize classical notion social forces agents attempt suppress prediction errors conflict with their expectations. By exploring parameter space belief-based model, reveal nontrivial relationships between beliefs group properties like polarization tendency visit different states. also explore how about uncertainty determine decision-making accuracy. Finally, update generative model over time, resulting collectively more sensitive external fluctuations encode information robustly.

Language: Английский

Citations

15
Functional neuronal circuits emerge in the absence of developmental activity DOI Creative Commons
Dániel L. Barabási, Gregor F. P. Schuhknecht, Florian Engert

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 8, 2024

The complex neuronal circuitry of the brain develops from limited information contained in genome. After genetic code instructs birth neurons, emergence regions, and formation axon tracts, it is believed that temporally structured spiking activity shapes circuits for behavior. Here, we challenge learning-dominated assumption required circuit by quantifying its contribution to development visually-guided swimming larval zebrafish. We found visual experience had no effect on optomotor response (OMR) dark-reared then raised animals while pharmacologically silencing action potentials with sodium channel blocker tricaine. washout anesthetic, fish could swim performed 75-90% accuracy OMR paradigm. Brain-wide imaging confirmed came 'online' fully tuned, without requiring activity-dependent plasticity. Thus, sensory-guided behaviors can emerge through activity-independent developmental mechanisms.

Language: Английский

Citations

14
Development of neural circuits for social motion perception in schooling fish DOI Creative Commons
David Zada, Lisanne Schulze, Jo‐Hsien Yu

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(15), P. 3380 - 3391.e5

Published: July 17, 2024

The collective behavior of animal groups emerges from the interactions among individuals. These social produce coordinated movements bird flocks and fish schools, but little is known about their developmental emergence neurobiological foundations. By characterizing visually based schooling micro glassfish Danionella cerebrum, we found that development progresses sequentially, with animals first acquiring ability to aggregate, followed by postural alignment partners. This maturation was accompanied neural populations in midbrain were preferentially driven visual stimuli resemble shape fish. Furthermore, isolation over course impaired both encoding motion adults. work demonstrates selective for form conspecifics emerge experience-dependent movement.

Language: Английский

Citations

12
Active interactions between animals and technology: biohybrid approaches for animal behaviour research DOI Creative Commons
Marina Papadopoulou,

M. Ball,

Palina Bartashevich

et al.

Animal Behaviour, Journal Year: 2025, Volume and Issue: unknown, P. 123160 - 123160

Published: April 1, 2025

Language: Английский

Citations

1
Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish DOI Creative Commons
Caroline Lei Wee, Erin Song,

Maxim Nikitchenko

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: May 11, 2022

Abstract Animal brains have evolved to encode social stimuli and transform these representations into advantageous behavioral responses. The commonalities differences of across species are not well-understood. Here, we show that isolation activates an oxytocinergic (OXT), nociceptive circuit in the larval zebrafish hypothalamus chemical cues released from conspecific animals potent modulators this circuit’s activity. We delineate olfactory subpallial pathway transmits OXT circuitry, where they transformed diverse outputs simultaneously regulating avoidance feeding behaviors. Our data allow us propose a model through which integrated within fundamental neural mediate adaptive behaviours.

Language: Английский

Citations

36
Parallelized computational 3D video microscopy of freely moving organisms at multiple gigapixels per second DOI
Kevin C. Zhou, Mark Harfouche, Colin Cooke

et al.

Nature Photonics, Journal Year: 2023, Volume and Issue: 17(5), P. 442 - 450

Published: March 20, 2023

Language: Английский

Citations

20
Visual processing and collective motion-related decision-making in desert locusts DOI Creative Commons
Itay Bleichman, Pratibha Yadav, Amir Ayali

et al.

Proceedings of the Royal Society B Biological Sciences, Journal Year: 2023, Volume and Issue: 290(1991)

Published: Jan. 18, 2023

Collectively moving groups of animals rely on the decision-making locally interacting individuals in order to maintain swarm cohesion. However, complex and noisy visual environment poses a major challenge extraction processing relevant information. We addressed this by studying swarming-related desert locust last-instar nymphs. Controlled stimuli, form random dot kinematograms, were presented tethered nymphs trackball set-up, while monitoring movement trajectory walking parameters. In complementary set experiments, neurophysiological basis observed behavioural responses was explored. Our results suggest that locusts use filtering discrimination upon encountering multiple stimuli simultaneously. Specifically, we show are sensitive differences speed at individual conspecific level, coherence group may these filter out non-relevant stimuli. The also discriminate assign different weights with an interactive effect stimulus size, relative abundance motion direction. findings provide insights into cognitive abilities domain visual-based collective motion, support as model for investigating sensory-motor integration motion-related intricate environment.

Language: Английский

Citations

18
Diving into the zebrafish brain: exploring neuroscience frontiers with genetic tools, imaging techniques, and behavioral insights DOI Creative Commons
Olga Doszyn, Tomasz Dulski, Justyna Zmorzyńska

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: March 12, 2024

The zebrafish ( Danio rerio ) is increasingly used in neuroscience research. Zebrafish are relatively easy to maintain, and their high fecundity makes them suitable for high-throughput experiments. Their small, transparent embryos larvae allow microscopic imaging of the developing brain. also share a degree genetic similarity with humans, amenable manipulation techniques, such as gene knockdown, knockout, or knock-in, which allows researchers study role specific genes relevant human brain development, function, disease. can serve model behavioral studies, including locomotion, learning, social interactions. In this review, we present state-of-the-art methods function zebrafish, tools labeling single neurons neuronal circuits, live neural activity, synaptic dynamics protein interactions brain, optogenetic manipulation, use virtual reality technology testing. We highlight potential research, especially regarding genetic-based disorders discuss its certain limitations model.

Language: Английский

Citations

8
Nature-Inspired Intelligent Computing: A Comprehensive Survey DOI Creative Commons
Licheng Jiao, Jiaxuan Zhao, Chao Wang

et al.

Research, Journal Year: 2024, Volume and Issue: 7

Published: Jan. 1, 2024

Nature, with its numerous surprising rules, serves as a rich source of creativity for the development artificial intelligence, inspiring researchers to create several nature-inspired intelligent computing paradigms based on natural mechanisms. Over past decades, these have revealed effective and flexible solutions practical complex problems. This paper summarizes mechanisms diverse advanced paradigms, which provide valuable lessons building general-purpose machines capable adapting environment autonomously. According mechanisms, we classify into 4 types: evolutionary-based, biological-based, social-cultural-based, science-based. Moreover, this also illustrates interrelationship between well their real-world applications, offering comprehensive algorithmic foundation mitigating unreasonable metaphors. Finally, detailed analysis challenges current promising future research directions are presented.

Language: Английский

Citations

8