Vascular endothelial cell development and diversity

Nature Reviews Cardiology, Journal Year: 2022, Volume and Issue: 20(3), P. 197 - 210

Published: Oct. 5, 2022

Language: Английский

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Origin and Heterogeneity of Tissue Myeloid Cells: A Focus on GMP-Derived Monocytes and Neutrophils

Annual Review of Immunology, Journal Year: 2023, Volume and Issue: 41(1), P. 375 - 404

Published: April 26, 2023

Myeloid cells are a significant proportion of leukocytes within tissues, comprising granulocytes, monocytes, dendritic cells, and macrophages. With the identification various myeloid that perform separate but complementary functions during homeostasis disease, our understanding tissue has evolved significantly. Exciting findings from transcriptomics profiling fate-mapping mouse models have facilitated their developmental origins, maturation, tissue-specific specializations. This review highlights current contributing factors functional heterogeneity to better comprehend complex dynamic immune interactions healthy or inflamed tissue. Specifically, we discuss new contributions granulocyte-monocyte progenitor–derived phagocytes cell as well impact niche-specific on monocyte neutrophil phenotype function. Lastly, explore developing paradigm inflammation disease.

Language: Английский

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Endothelial and Leptin Receptor+ cells promote the maintenance of stem cells and hematopoiesis in early postnatal murine bone marrow

Developmental Cell, Journal Year: 2023, Volume and Issue: 58(5), P. 348 - 360.e6

Published: March 1, 2023

Mammalian hematopoietic stem cells (HSCs) colonize the bone marrow during late fetal development, and this becomes major site of hematopoiesis after birth. However, little is known about early postnatal niche. We performed single-cell RNA sequencing mouse stromal at 4 days, 14 8 weeks Leptin-receptor-expressing (LepR+) endothelial increased in frequency period changed their properties. At all stages, LepR+ expressed highest cell factor (Scf) levels marrow. Cxcl12 levels. In marrow, SCF from LepR+/Prx1+ promoted myeloid erythroid progenitor maintenance, while HSC maintenance. Membrane-bound contributed to are thus important niche components

Language: Английский

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YAP and TAZ couple osteoblast precursor mobilization to angiogenesis and mechanoregulation in murine bone development

Developmental Cell, Journal Year: 2023, Volume and Issue: 59(2), P. 211 - 227.e5

Published: Dec. 22, 2023

Language: Английский

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Bone marrow niches for hematopoietic stem cells: life span dynamics and adaptation to acute stress

Blood, Journal Year: 2024, Volume and Issue: 144(1), P. 21 - 34

Published: April 5, 2024

Language: Английский

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Uncovering the emergence of HSCs in the human fetal bone marrow by single-cell RNA-seq analysis

Cell stem cell, Journal Year: 2022, Volume and Issue: 29(11), P. 1562 - 1579.e7

Published: Nov. 1, 2022

Language: Английский

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Murine fetal bone marrow does not support functional hematopoietic stem and progenitor cells until birth

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 15, 2022

Abstract While adult bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs) their extrinsic regulation is well studied, little known about the composition, function, of first HSPCs to enter BM during development. Here, we functionally interrogate murine from E15.5 through P0. Our work reveals that fetal are present by E15.5, but distinct HSPC pool seen in liver, both phenotypically functionally, until near birth. We also generate a transcriptional atlas perinatal niche mice across ontogeny, revealing lacks with robust intrinsic cell programs, as supportive HSPCs. In contrast, programs preserved neonatal HSPCs, which reside expressing HSC factors those adults. Collectively, our results provide important insights into shaping hematopoiesis this understudied window

Language: Английский

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The role of the haematopoietic stem cell niche in development and ageing

Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Language: Английский

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Hematopoietic stem cell niche generation and maintenance are distinguishable by an epitranscriptomic program

Cell, Journal Year: 2024, Volume and Issue: 187(11), P. 2801 - 2816.e17

Published: April 23, 2024

Language: Английский

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Enhancement of adipose stem cell quality via Cu‐MON: Transcriptome and bioinformatics analysis of normal and diabetic stem cells

FASEB BioAdvances, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 18, 2025

Abstract Transplanted adipose stem cells (ASC) have a low survival rate in the body, and there are not many ASC that can be effectively used, which weakens their tissue repair function. Based on this status quo, new type of copper‐based metal–organic network (Cu‐MON) was used to pretreat regulate cell activity order improve efficacy therapy or reduce number thus reducing cost clinical treatment. Gene expression changes before after Cu‐MON treatment normal donor (ND‐ASC) 2 diabetes mellitus (T2DM‐ASC) were evaluated through RNA sequencing, KEGG GO enrichment analysis. The results showed improved quality by regulating immune response promoting paracrine secretion. IL‐17 signaling pathway IL‐6, CXCL8, MMP‐9 key pathways necessary genes affected ability cells. In addition, also antiviral Type I interferon pathway. Our research had response, secretion, improving capabilities. This approach biomaterial pretreatment is fast, convenient, relatively safe, provides strategies for efficiency therapies.

Language: Английский

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