Fuel Processing Technology, Journal Year: 2023, Volume and Issue: 247, P. 107798 - 107798
Published: May 3, 2023
Language: Английский
Nature Reviews Materials, Journal Year: 2023, Volume and Issue: 8(7), P. 422 - 438
Published: March 24, 2023
Language: Английский
Citations
284
Nature Nanotechnology, Journal Year: 2023, Volume and Issue: 18(9), P. 1067 - 1077
Published: Aug. 3, 2023
Language: Английский
Citations
78
Advanced Science, Journal Year: 2023, Volume and Issue: 10(6)
Published: Jan. 3, 2023
Abstract Covalent organic frameworks (COFs) have attracted increasing attention for biomedical applications. COFs‐based nanosensitizers with uniform nanoscale morphology and tumor‐specific curative effects are in high demand; however, their synthesis is yet challenging. In this study, distinct COF nanobowls synthesized a controlled manner engineered as activatable sonodynamic activity. High crystallinity ensures an ordered porous structure of the efficient loading small‐molecule sonosensitizer rose bengal (RB). To circumvent non‐specific damage to normal tissues, sonosensitization effect specifically inhibited by situ growth manganese oxide (MnO x ) on RB‐loaded COFs. Upon reaction tumor‐overexpressed glutathione (GSH), “gatekeeper” MnO rapidly decomposed recover reactive oxygen species (ROS) generation capability under ultrasound irradiation. Increased intracellular ROS stress GSH consumption concomitantly induce ferroptosis improve efficacy. Additionally, unconventional bowl‐shaped renders enhanced tumor accumulation retention. The combination therapy achieves efficacy killing cancer cells inhibiting growth. This study paves way development morphologies biomedicine, offering paradigm realize ferroptosis‐augmented therapy.
Language: Английский
Citations
71
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(19)
Published: Feb. 7, 2024
The common clinical chemotherapy often brings serious side effects to patients, mainly due the off-target and leakage of toxic drugs. However, this is fatal for some specific tumors, such as brain tumors neuroma. This study performs a drug-free approach by encapsulating black phosphorus (BP) calcium peroxide (CaO
Language: Английский
Citations
18
Advanced Science, Journal Year: 2024, Volume and Issue: 11(26)
Published: May 5, 2024
Abstract It is newly revealed that collagen works as a physical barrier to tumor immune infiltration, oxygen perfusion, and depressor in solid tumors. Meanwhile, after radiotherapy (RT), the programmed death ligand‐1 (PD‐L1) overexpression transforming growth factor‐β (TGF‐β) excessive secretion would accelerate DNA damage repair trigger T cell exclusion limit RT efficacy. However, existing drugs or nanoparticles can hardly address these obstacles of highly effective simultaneously, effectively, easily. In this study, it inducing mitochondria dysfunction by using oxidative phosphorylation inhibitors like Lonidamine (LND) serve multi‐immune pathway regulation strategy through PD‐L1, collagen, TGF‐β co‐depression. Then, IR‐LND prepared combining mitochondria‐targeted molecule IR‐68 with LND, which then loaded liposomes (Lip) create IR‐LND@Lip nanoadjuvants. By doing this, more effectively sensitizes generating cold tumors into hot ones activation co‐inhibition. conclusion, combined treatment ultimately almost completely suppressed bladder breast
Language: Английский
Citations
17
Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123138 - 123138
Published: Jan. 28, 2025
Language: Английский
Citations
2
Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(12), P. 2605 - 2605
Published: Nov. 26, 2022
Nanoparticles (NPs) are versatile candidates for nanomedical applications due to their unique physicochemical properties. However, clinical applicability is hindered by undesirable recognition the immune system and consequent immunotoxicity, as well rapid clearance in vivo. After injection, NPs usually covered with layers of proteins, called protein coronas (PCs), which alter identity, biodistribution, half-life, efficacy. Therefore, characterization PC predicting fate The aim this review was summarize state art regarding intrinsic factors closely related NP structure, extrinsic that govern formation vitro. In addition, well-known opsonins, including complement, immunoglobulins, fibrinogen, dysopsonins, such histidine-rich glycoprotein, apolipoproteins, albumin, described relation role detection cells. Particular emphasis placed on mediating interaction innate adaptive Finally, strategies reduce discussed detail.
Language: Английский
Citations
51
Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 355, P. 593 - 603
Published: Feb. 15, 2023
Language: Английский
Citations
38
Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(7), P. 499 - 517
Published: March 22, 2023
Language: Английский
Citations
38
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 199 - 199
Published: Jan. 6, 2023
Gelatin is a biocompatible, biodegradable, cheap, and nontoxic material, which already used for pharmaceutical applications. Nanoparticles from gelatin (GNPs) are considered promising delivery system hydrophilic macromolecular drugs. Mechanical properties of particles recognized as an important parameter affecting drug carrier interaction with biological systems. GNPs offer the preparation different stiffness. were loaded Fluorescein isothiocyanate-labeled 150 kDa dextran (FITC-dextran) yielding also elastic properties. visualized using atomic force microscopy (AFM), force-distance curves center evaluated Young's modulus calculation. The prepared have moduli 4.12 MPa soft to 9.8 stiff particles. Furthermore, cytokine release (IL-6 TNF-α), cell viability, uptake determined on macrophage lines mouse (RAW 264.7) human (dTHP-1 cells, differentiated monocytic THP-1 cells) origin GNPs. Both particle types showed good compatibility did not induce IL-6 TNF-α RAW 264.7 dTHP-1 cells. Stiffer internalized into cells faster larger extent.
Language: Английский
Citations
29