Protein‐Integrated Hydrogen‐Bonded Organic Frameworks: Chemistry and Biomedical Applications DOI
L. J. Li, Tianyu Ma, Ming Wang

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(21)

Published: March 26, 2024

Abstract Hydrogen‐bonded organic frameworks (HOFs) are porous nanomaterials that offer exceptional biocompatibility and versatility for integrating proteins biomedical applications. This minireview concisely discusses recent advancements in the chemistry functionality of protein‐HOF interfaces. It particularly focuses on strategic methodologies, such as careful selection building blocks genetic engineering proteins, to facilitate interactions. We examine role enzyme encapsulation within HOFs, highlighting its capability preserve function, a crucial aspect applications biosensing disease diagnosis. Moreover, we discuss emerging utility nanoscale HOFs intracellular protein delivery, illustrating their applicability nanoreactors catalysis neuroprotective biorthogonal cellular compartments. highlight significant advancement designing biodegradable tailored cytosolic underscoring promising application targeted cancer therapies. Finally, provide perspective viewpoint design biocompatible assemblies, underlining prospects drug diagnosis, broader

Language: Английский

Exploring Multifunctional Hydrogen-Bonded Organic Framework Materials DOI
Zhangjing Zhang,

Yingxiang Ye,

Shengchang Xiang

et al.

Accounts of Chemical Research, Journal Year: 2022, Volume and Issue: 55(24), P. 3752 - 3766

Published: Dec. 1, 2022

ConspectusHydrogen-bonded organic framework (HOF) materials have provided a new dimension and bright promise as platform for developing multifunctional materials. They can be readily self-assembled from their corresponding molecules with diverse functional sites such carboxylic acid amine groups hydrogen bonding aromatic ones weak π···π interactions to stabilize the frameworks. Compared those established porous zeolites, metal–organic frameworks (MOFs), covalent–organic (COFs), it is much more difficult HOFs thus establish permanent porosities given fact that bonds are typically weaker than ionic, coordination, covalent bonds. But provides uniqueness of HOF in which they easily recovered regenerated through simple recrystallization. also straightforwardly processed very compatible biomolecules, making them potentially useful industrial biomedical applications. The reversible nature utilized construct flexible we tune temperature pressure control and, thus, applications, example, on gas separations, storage, drug delivery, sensing. Some specific quite directional bond formations; prefers form dimer, has enabled us reticular whose pores systematically tuned. In this Account, outline our journey exploring type material by establishing one first 2011 its We been able use different sites, including 2,4-diaminotriazine (DAT), (COOH), aldehyde (CHO), cyano (CN), HOFs. Through tuning pore sizes, introducing binding flexibility, realized series separations C2H2/C2H4, C2H4/C2H6, C3H6/C3H8, C2H2/CO2, CO2/N2, Xe/Kr enantioselective separation alcohols. To make optically active molecules, developed luminescent sensing optical lasing. Our research endeavors initiated extensive emerging topic among chemistry sciences communities. foresee not only many will but novel functions fulfilled beyond imaginations soon.

Language: Английский

Citations

181
Microenvironment Engineering of Single/Dual‐Atom Catalysts for Electrocatalytic Application DOI Open Access
Yun Gao, Baozhong Liu, Dingsheng Wang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(31)

Published: Feb. 23, 2023

Single/dual-metal atoms supported on carbon matrix can be modulated by coordination structure and neighboring active sites. Precisely designing the geometric electronic uncovering structure-property relationships of single/dual-metal confront with grand challenges. Herein, this review summarizes latest progress in microenvironment engineering single/dual-atom sites via a comprehensive comparison single-atom catalyst (SACs) dual-atom catalysts (DACs) term design principles, modulation strategy, theoretical understanding structure-performance correlations. Subsequently, recent advances several typical electrocatalysis process are discussed to get general reaction mechanisms finely-tuned SACs DACs. Finally, full-scaled summaries challenges prospects given for This will provide new inspiration development atomically dispersed electrocatalytic application.

Language: Английский

Citations

181
Multifunctional Porous Hydrogen-Bonded Organic Frameworks: Current Status and Future Perspectives DOI Creative Commons
Zu‐Jin Lin, A. R. Mahammed Shaheer, Tian‐Fu Liu

et al.

ACS Central Science, Journal Year: 2022, Volume and Issue: 8(12), P. 1589 - 1608

Published: Dec. 16, 2022

Hydrogen-bonded organic frameworks (HOFs), self-assembled from or metalated building blocks (also termed as tectons) by hydrogen bonding, π–π stacking, and other intermolecular interactions, have become an emerging class of multifunctional porous materials. So far, a library HOFs with high porosity has been synthesized based on versatile tectons supramolecular synthons. Benefiting the flexibility reversibility H-bonds, feature structural flexibility, mild synthetic reaction, excellent solution processability, facile healing, easy regeneration, good recyclability. However, flexible reversible nature H-bonds makes most suffer poor designability low framework stability. In this Outlook, we first describe development features summarize design principles strategies to enhance their Second, highlight state-of-the-art for diverse applications, including gas storage separation, heterogeneous catalysis, biological sensing, proton conduction, applications. Finally, current challenges future perspectives are discussed.

Language: Английский

Citations

166
Hydrogen-bonded organic framework-based bioorthogonal catalysis prevents drug metabolic inactivation DOI
Congcong Huang, Chuanqi Zhao, Qingqing Deng

et al.

Nature Catalysis, Journal Year: 2023, Volume and Issue: 6(8), P. 729 - 739

Published: Aug. 10, 2023

Language: Английский

Citations

62
Structural Motifs in Covalent Organic Frameworks for Photocatalysis DOI

Liyang Qin,

Chengdi Ma,

Jian Zhang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: March 10, 2024

Abstract Covalent organic frameworks (COFs) attract significant attention due to their ordered, crystalline, porous, metal‐free, and predictable structures. These unique characteristics offer great opportunities for the diffusion transmission of photogenerated charges during photocatalysis. Currently, a considerable number COFs are used as metal‐free semiconductor photocatalysts. This review aims understand relationships between structure photocatalysis performance provides in‐depth insight into synthetic strategy improve performance. Subsequently, focuses on structural motif in sustainable photocatalytic hydrogen evolution, carbon dioxide reduction, peroxide generation, compound transformations. Last, conjunction with progress achieved challenges yet be overcome, candid discussion is undertaken regarding field COF photocatalysis, accompanied by presentation potential research avenues future directions. seeks provide readers comprehensive understanding pivotal role robust guidance innovative utilization

Language: Английский

Citations

61
Encapsulating and stabilizing enzymes using hydrogen-bonded organic frameworks DOI
Guosheng Chen, Siming Huang, Xiaomin Ma

et al.

Nature Protocols, Journal Year: 2023, Volume and Issue: 18(7), P. 2032 - 2050

Published: May 17, 2023

Language: Английский

Citations

59
Hydrogen-bonded organic frameworks: new horizons in biomedical applications DOI

Dongqin Yu,

Haochen Zhang, Jinsong Ren

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(21), P. 7504 - 7523

Published: Jan. 1, 2023

Hydrogen-bonded organic frameworks (HOFs) are an emerging attractive class of highly crystalline porous materials characterized by significant biocompatibility, rich chemical functionalities and well-defined porosity. The unique advantages including metal-free nature reversible binding manner significantly distinguish HOFs from other in the biotechnology biomedical field. However, relevant HOF studies still remain their infancy despite promising remarkable results that have been presented recent years. Due to intricate dynamic physiological conditions, major challenge lies stability structural diversity vivo. In this Tutorial Review, we summarize common building blocks for construction HOF-based functional biomaterials latest developments biological Moreover, highlight current challenges regarding functionalization along with corresponding potential solutions. This Review will a profound effect future years on design applications biomaterials.

Language: Английский

Citations

57
Harnessing Self-Repairing and Crystallization Processes for Effective Enzyme Encapsulation in Covalent Organic Frameworks DOI
Yufeng Zhang,

Chunyan Xing,

Zhenjie Mu

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(24), P. 13469 - 13475

Published: June 7, 2023

Immobilization of fragile enzymes in crystalline porous materials offers new opportunities to expand the applications biocatalysts. However, limited by pore size and/or harsh synthesis conditions hosts, often suffer from dimension limitation or denaturation during immobilization process. Taking advantage dynamic covalent chemistry feature organic frameworks (COFs), herein, we report a preprotection strategy encapsulate COFs self-repairing and crystallization Enzymes were first loaded low-crystalline polymer networks with mesopores formed at initial growth stage, which could offer effective protection for reaction conditions, subsequently encapsulation proceeded disordered into framework. Impressively, biological activity can be well-maintained after encapsulation, obtained enzyme@COFs also show superior stability. Furthermore, circumvents enzymes, its versatility was verified different sizes surface charges, as well two-enzyme cascade system. This study universal design idea robust supports holds promise developing high-performance immobilized

Language: Английский

Citations

56
Pore‐Environment‐Dependent Photoresponsive Oxidase‐Like Activity in Hydrogen‐Bonded Organic Frameworks DOI

Linjing Tong,

Yuhong Lin,

Xiaoxue Kou

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(13)

Published: Jan. 31, 2023

Abstract Mimicking the bioactivity of native enzymes through synthetic chemistry is an efficient means to advance biocatalysts in a cell‐free environment, however, remains long‐standing challenges. Herein, we utilize structurally explicit hydrogen‐bonded organic frameworks (HOFs) mimic photo‐responsive oxidase, and uncover important role pore environments on mediating oxidase‐like activity by constructing isostructural HOFs. We discover that HOF with suitable geometry can stabilize spatially organize catalytic substrate into favorable route, as function enzyme pocket. Based desirable activity, visual sensitive HOFs biosensor established for detection phosphatase, biomarker skeletal hepatobiliary diseases. This work demonstrates significantly influence nanozymes’ addition active center.

Language: Английский

Citations

54
Green synthesis of stable hybrid biocatalyst using a hydrogen-bonded, π-π-stacking supramolecular assembly for electrochemical immunosensor DOI Creative Commons
Wei Huang, Haitao Yuan, Hongling Yang

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: June 20, 2023

Abstract Rational integration of native enzymes and nanoscaffold is an efficient means to access robust biocatalyst, yet remains on-going challenges due the trade-off between fragile harsh assembling conditions. Here, we report a supramolecular strategy enabling in situ fusion into porous crystal. A c2-symmetric pyrene tecton with four formic acid arms utilized as building block engineer this hybrid biocatalyst. The decorated afford tectons high dispersibility minute amount organic solvent, permit hydrogen-bonded linkage discrete extended network around enzyme almost solvent-free aqueous solution. This biocatalyst covered by long-range ordered pore channels, which can serve gating sieve catalytic substrate thus enhance biocatalytic selectivity. Given structural integration, biocatalyst-based electrochemical immunosensor developed, pg/mL detection cancer biomarker.

Language: Английский

Citations

46