Applied Materials Today, Journal Year: 2024, Volume and Issue: 37, P. 102141 - 102141
Published: Feb. 27, 2024
Language: Английский
Neuron, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Medicinal Research Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: April 12, 2025
Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design mode application have made them useful tools studying dynamic biological processes in vitro vivo. Recently, there has been growing body data investigating potential development drug delivery systems. Of various PPG scaffolds use, quinoline photocages history about 20 years. The structure-property relationships PPGs, as well alternative multibranch designs based on monomers thoroughly studied both experimentally theoretically. Therefore, PPGs serve representative study development, showing how applications followed chemical optimization or drove design. Since raison d'être lies light-activated performing structural changes materials, it is crucial to understand are selected utilized end-users, who often not chemists themselves. we discuss whether conclusions drawn from family could lead more general insights field whole. As PPG-related still rely heavily limited number scaffolds, worth considering, what be reasons slow uptake novel scaffolds.
Language: Английский
Citations
0
Biophysics Reviews, Journal Year: 2023, Volume and Issue: 4(1)
Published: Jan. 20, 2023
Light has broad applications in medicine as a tool for diagnosis and therapy. Recent advances optical technology bioelectronics have opened opportunities wearable, ingestible, implantable devices that use light to continuously monitor health precisely treat diseases. In this review, we discuss recent progress the development application of light-based bioelectronic devices. We summarize key features technologies underlying these devices, including sources, detectors, energy storage harvesting, wireless power communications. investigate current state continuous measurement on-demand delivery Finally, highlight major challenges associated with their promise enabling digital forms care.
Language: Английский
Citations
8
Small, Journal Year: 2023, Volume and Issue: 19(39)
Published: June 1, 2023
Abstract Precisely delivering light to multiple locations in biological tissue is crucial for advancing multiregional optogenetics neuroscience research. However, conventional implantable devices typically have rigid geometries and limited sources, allowing only single or dual probe placement with fixed spacing. Here, a fully flexible optogenetic device thin‐film microscale light‐emitting diode (µ‐LED) displays scattering from central controller presented. Each display heterogeneously integrated 5 × 10 µ‐LEDs five optical fibers 125 µm diameter achieve cellular‐scale spatial resolution. Meanwhile, the boasts compact, circuit capable of multichannel configuration wireless transmission, an overall weight 1.31 g, enabling wireless, real‐time neuromodulation freely moving rats. Characterization results finite element analysis demonstrated excellent properties mechanical stability, while cytotoxicity tests further ensure biocompatibility applications. Behavior studies under modulation indicate great promise wirelessly modulating neural functions animals. The multisite capability offers comprehensive platform advance both fundamental potential applications brain‐computer interfaces.
Language: Английский
Citations
7
Applied Materials Today, Journal Year: 2024, Volume and Issue: 37, P. 102141 - 102141
Published: Feb. 27, 2024
Language: Английский
Citations
2