Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Aug. 15, 2024
Microflow
catalysis
is
a
cutting-edge
approach
to
advancing
chemical
synthesis
and
manufacturing,
but
the
challenge
lies
in
developing
efficient
stable
multiphase
catalysts.
Here
we
showcase
incorporating
amine-containing
metal-organic
cages
into
automated
microfluidic
reactors
through
covalent
bonds,
enabling
highly
continuous
flow
catalysis.
Two
Fe4L4
tetrahedral
bearing
four
uncoordinated
amines
were
designed
synthesized.
Post-synthetic
modifications
of
amine
groups
with
3-isocyanatopropyltriethoxysilane,
introducing
silane
chains
immobilized
on
inner
walls
reactor.
The
prove
for
reaction
anthranilamide
aldehydes,
showing
superior
reactivity
recyclability
relative
free
cages.
This
superiority
arises
from
large
cavity,
facilitating
substrate
accommodation
conversion,
high
mass
transfer
rate
bonds
between
cage
microreactor.
study
exemplifies
synergy
microreactor
technology,
highlighting
benefits
heterogenous
potential
future
processes
represents
method
though
catalysts
remains
challenging.
authors
demonstrate
incorporation
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: May 11, 2023
Abstract
Transition
metal-based
homogeneous
photocatalysts
offer
a
wealth
of
opportunities
for
organic
synthesis.
The
most
versatile
ruthenium(II)
and
iridium(III)
polypyridyl
complexes,
however,
are
among
the
rarest
metal
complexes.
Moreover,
immobilizing
these
precious
catalysts
recycling
is
challenging
as
their
opacity
may
obstruct
light
transmission.
Recovery
by
conventional
polymeric
membranes
promising
but
limited,
modulation
pore
structure
tolerance
polar
solvents
challenging.
Here,
we
report
effective
recovery
using
covalent
framework
(COF)
membranes.
An
array
COF
with
tunable
sizes
superior
solvent
resistance
were
prepared.
Ruthenium
iridium
photoredox
recycled
10
cycles
in
various
types
photochemical
reactions,
constantly
achieving
high
catalytical
performance,
rates,
permeance.
We
successfully
recovered
at
gram-scale.
Furthermore,
demonstrated
cascade
isolation
an
photocatalyst
purification
small
molecule
product
possessing
different
sizes.
Our
results
indicate
intriguing
potential
to
shift
paradigm
pharmaceutical
fine
chemical
synthesis
campaign.
Organic Process Research & Development,
Journal Year:
2024,
Volume and Issue:
28(4), P. 891 - 923
Published: March 22, 2024
Separation
and
purification
in
organic
solvents
are
indispensable
procedures
pharmaceutical
manufacturing.
However,
they
still
heavily
rely
on
the
conventional
separation
technologies
of
distillation
chromatography,
resulting
high
energy
massive
solvent
consumption.
As
an
alternative,
nanofiltration
(OSN)
offers
benefits
low
consumption,
solid
waste
generation,
easy
scale-up
incorporation
into
continuous
processes.
Thus,
there
is
a
growing
interest
employing
membrane
technology
area
to
improve
process
sustainability
efficiency.
This
Review
comprehensively
summarizes
recent
progress
(especially
last
10
years)
its
applications
industry,
including
concentration
active
ingredients,
homogeneous
catalyst
recovery,
exchange
OSN-assisted
peptide/oligonucleotide
synthesis.
Furthermore,
challenges
future
perspectives
discussed
detail.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(19), P. 3799 - 3842
Published: Jan. 1, 2024
Tetrabutylammonium
decatungstate
(TBADT)
has
recently
emerged
as
an
intriguing
photocatalyst
under
visible-light
or
near-visible-light
irradiation
in
a
wide
range
of
organic
reactions
that
were
previously
not
conceivable.
Given
its
ability
to
absorb
visible
light
and
excellent
effectiveness
activating
unactivated
chemical
bonds,
it
is
promising
addition
traditional
photocatalysts.
This
review
covers
some
the
contemporary
developments
photocatalysis
enabled
by
TBADT
catalyst
2023,
with
contents
organized
reaction
type.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(52)
Published: Nov. 17, 2023
Electrophotocatalytic
transformations
are
garnering
attention
in
organic
synthesis,
particularly
for
accessing
reactive
intermediates
under
mild
conditions.
Moving
these
methodologies
to
continuous-flow
systems,
or
flow
ElectroPhotoCatalysis
(f-EPC),
showcases
potential
scalable
processes
due
enhanced
irradiation,
increased
electrode
surface,
and
improved
mixing
of
the
reaction
mixture.
Traditional
methods
sequentially
link
photochemical
electrochemical
reactions,
using
reactors
connected
series,
yet
struggle
accommodate
transient
species.
In
this
study,
we
introduce
a
new
reactor
concept
electrophotocatalysis
(EPC)
that
simultaneously
utilizes
photons
electrons.
The
is
designed
with
transparent
employs
cost-effective
materials.
We
used
technology
develop
an
efficient
process
electrophotocatalytic
heteroarylation
C(sp3
)-H
bonds.
Importantly,
same
setup
can
also
facilitate
purely
transformations.
This
represents
significant
advancement
electrophotocatalysis,
providing
framework
its
application
complex
synthetic
ChemSusChem,
Journal Year:
2024,
Volume and Issue:
17(16)
Published: April 12, 2024
Abstract
Photocatalytic
synthesis
of
value‐added
chemicals
has
gained
increasing
attention
in
recent
years
owing
to
its
versatility
driving
many
important
reactions
under
ambient
conditions.
Selective
hydrogenation,
oxidation,
coupling,
and
halogenation
with
a
high
conversion
the
reactants
have
been
realized
using
designed
photocatalysts
batch
reactors
small
volumes
at
laboratory
scale;
however,
scaling‐up
remains
critical
challenge
due
inefficient
utilization
incident
light
active
sites
photocatalysts,
resulting
poor
catalytic
performance
that
hinders
practical
applications.
Flow
systems
are
considered
one
solutions
for
applications
light‐driven
experienced
great
success
photolytic
homogeneous
photocatalysis,
yet
their
heterogeneous
photocatalysis
still
development.
In
this
perspective,
we
summarized
progress
photocatalytic
synthetic
chemistry
performed
flow
from
view
reactor
design
special
focus
on
photocatalysis.
The
advantages
limitations
different
systems,
as
well
some
considerations
strategies
discussed.
