Pheromone representation in the ant antennal lobe changes with age

Current Biology, Journal Year: 2024, Volume and Issue: 34(14), P. 3233 - 3240.e4

Published: June 13, 2024

While the neural basis of age-related decline has been extensively studied,1Damoiseaux J.S. Effects aging on functional and structural brain connectivity.Neuroimage. 2017; 160: 32-40https://doi.org/10.1016/j.neuroimage.2017.01.077Crossref PubMed Scopus (348) Google Scholar,2Tamura T. Chiang A.-S. Ito N. Liu H.-P. Horiuchi J. Tully Saitoe M. Aging specifically impairs amnesiac-dependent memory in Drosophila.Neuron. 2003; 40: 1003-1011https://doi.org/10.1016/S0896-6273(03)00732-3Abstract Full Text PDF (0) Scholar,3Swenson B.L. Meyer C.F. Bussian T.J. Baker D.J. Senescence disorders central nervous system.Transl. Med. Aging. 2019; 3: 17-25https://doi.org/10.1016/j.tma.2019.01.002Crossref Scholar less is known about changes function during pre-senescent stages adulthood. Adult plasticity likely a key factor social insect age polyethism, where individuals perform different tasks as they divide labor an age-dependent manner.4Beshers S.N. Fewell J.H. Models division insects.Annu. Rev. Entomol. 2001; 46: 413-440https://doi.org/10.1146/annurev.ento.46.1.413Crossref (674) Scholar,5Richardson T.O. Kay Braunschweig R. Journeau O.A. Rüegg McGregor S. Los Rios P.D. Keller L. Ant behavioral maturation mediated by stochastic transition between two fundamental states.Curr. Biol. 2021; 31: 2253-2260.e3https://doi.org/10.1016/j.cub.2020.05.038Abstract (12) Scholar,6Caminer M.A. Libbrecht Majoe Ho D.V. Baumann P. Foitzik Task-specific odorant receptor expression worker antennae indicates that sensory filters regulate ants.Commun. 2023; 6: 1004https://doi.org/10.1038/s42003-023-05273-4Crossref Scholar,7Ferguson S.T. Bakis I. Edwards N.D. Zwiebel L.J. Age task modulate olfactory sensitivity Florida carpenter ant Camponotus floridanus.Insects. 14: 724https://doi.org/10.3390/insects14090724Crossref Scholar,8Page R.E. Erber Levels organization evolution labor.Naturwissenschaften. 2002; 89: 91-106https://doi.org/10.1007/s00114-002-0299-xCrossref Scholar,9Lucas C. Ben-Shahar Y. The foraging gene modulator labour insects.J. Neurogenet. 35: 168-178https://doi.org/10.1080/01677063.2021.1940173Crossref Primarily, workers from nursing to tasks,5Richardson Scholar,10Robinson G.E. Page Huang Z.-Y. Temporal polyethism insects developmental process.Anim. Behav. 1994; 48: 467-469https://doi.org/10.1006/anbe.1994.1260Crossref become more aggressive, readily display alarm behavior11Robinson Modulation pheromone perception honey bee: evidence for based hormonally regulated response thresholds.J. Comp. Physiol. 1987; 613-619https://doi.org/10.1007/BF00611934Crossref Scholar,12Pokorny Sieber L.-M. Hofferberth J.E. Bernadou A. Ruther Age-dependent release ponerine ant.J. Exp. 2020; 223218040https://doi.org/10.1242/jeb.218040Crossref Scholar,13Norman V.C. Hoppé Hughes W.O.H. Old wise but not size: factors affecting threat behaviour nestmate recognition Acromyrmex echinatior leaf-cutting ants.Insectes Soc. 2014; 61: 289-296https://doi.org/10.1007/s00040-014-0355-5Crossref Scholar,14Togni O.C. Giannotti E. Colony defense behavior primitively eusocial wasp, Mischocyttarus cerberus related age.J. Insect Sci. 2010; 10: 136https://doi.org/10.1673/031.010.13601Crossref (10) Scholar,15Giray Genetic variation temporal colony defensiveness bee, Apis mellifera.Behav. Ecol. 2000; 11: 44-55https://doi.org/10.1093/beheco/11.1.44Crossref Scholar,16Norman Butterfield Drijfhout F. Tasman K. Alarm composition activity fungus-growing ants.J. Chem. 43: 225-235https://doi.org/10.1007/s10886-017-0821-4Crossref get older. it unknown how these dynamics are neurally regulated, could partially be generated altered salience behaviorally relevant stimuli.4Beshers Here, we investigated odor coding antennal lobe (AL) with context communication clonal raider (Ooceraea biroi).17Lopes L.E. Frank E.T. Kárpáti Z. Schmitt Kronauer D.J.C. 49: 1-10https://doi.org/10.1007/s10886-023-01407-4Crossref (1) Similar other insects,11Robinson older ants responded rapidly pheromones, chemical signals danger. Using whole-AL calcium imaging,18Hart D.D. Lopes Olivos-Cisneros Lacy K.D. Trible W. Ritger Valdés-Rodríguez Sparse stereotyped encoding implicates core glomerulus behavior.Cell. 186: 3079-3094.e17https://doi.org/10.1016/j.cell.2023.05.025Abstract then mapped representations five general odorants pheromones young old ants. were represented sparsely at all ages. However, responses within individual glomeruli changed age, either increasing or decreasing. Only became sensitized while same time becoming desensitized odorants. Our results suggest heightened occurs via increased glomeruli, illustrating importance modulation age-associated plasticity.

Language: Английский

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Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons

Journal of Neuroinflammation, Journal Year: 2024, Volume and Issue: 21(1)

Published: Jan. 17, 2024

Abstract Background Venezuelan Equine Encephalitis virus ( VEEV) may enter the central nervous system (CNS) within olfactory sensory neurons (OSN) that originate in nasal cavity after intranasal exposure. While it is known VEEV has evolved several mechanisms to inhibit type I interferon (IFN) signaling infected cells, whether this inhibits virologic control during neuroinvasion along OSN not been studied. Methods We utilized an established murine model of infection with and a repository scRNAseq data from IFN-treated assess cellular targets IFN responses Results found immature OSN, which express higher levels receptor LDLRAD3 than mature are first cells by VEEV. Despite rapid exposure, neuroepithelium (ONE) bulb (OB) responses, as assessed evaluation expression genes (ISG), delayed for up 48 h neuroinvasion, representing potential therapeutic window. Indeed, single dose recombinant IFNα triggers early ISG both OB. When administered at time or infection, treatment onset sequelae associated encephalitis extended survival days. replication was also transiently suppressed ONE, inhibited subsequent invasion into CNS. Conclusions Our results demonstrate critical promising human encephalitic alphavirus exposures.

Language: Английский

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Establishment and maintenance of random monoallelic expression

Development, Journal Year: 2024, Volume and Issue: 151(10)

Published: May 15, 2024

ABSTRACT This Review elucidates the regulatory principles of random monoallelic expression by focusing on two well-studied examples: X-chromosome inactivation regulator Xist and olfactory receptor gene family. Although choice a single X chromosome or occurs in different developmental contexts, common guide both systems. In cases, an event breaks symmetry between genetically epigenetically identical copies gene, leading to one allele, stabilized through negative feedback control. many steps that govern establishment maintenance have been identified, key pieces puzzle are still missing. We provide overview current knowledge models for receptors. discuss their similarities differences, highlight open questions approaches could study other monoallelically expressed genes.

Language: Английский

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Cell type- and layer-specific plasticity of olfactory bulb interneurons following olfactory sensory neuron ablation

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 1, 2024

Lifelong neurogenesis endows the mouse olfactory system with a capacity for regeneration that is unique in mammalian nervous system. Throughout life, sensory neurons (OSNs) are generated from epithelium (OE) stem cells nose, while subventricular zone generates neuroblasts migrate to bulb (OB) and differentiate into multiple populations of inhibitory interneurons. Methimazole (MMZ) selectively ablates OSNs, but OE enables OSN repopulation gradual recovery input OB within 6 weeks. However, it not known how interneurons affected by this loss subsequent following MMZ treatment. We found dopaminergic neuron density was significantly reduced 7–14 days post-MMZ recovered substantially at 35 days. The parvalbumin-expressing unaffected MMZ; however, their soma size post-MMZ, recovering Surprisingly, we transient increase calretinin-expressing glomerular external plexiform layers, granule cell layer, 7 post-MMZ. This could be accounted increased may result calretinin expression. Together, our data demonstrate type- layer-specific changes interneuron morphology after treatment, providing new insight range plasticity mechanisms employed circuits during input.

Language: Английский

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Activity‐dependent formation of the topographic map and the critical period in the development of mammalian olfactory system

genesis, Journal Year: 2024, Volume and Issue: 62(1)

Published: Jan. 30, 2024

Summary Neural activity influences every aspect of nervous system development. In olfactory systems, sensory neurons expressing the same odorant receptor project their axons to stereotypically positioned glomeruli, forming a spatial map receptors in bulb. As individual odors activate unique combinations this forms basis for encoding information. The establishment stereotypical requires coordinated regulation axon guidance molecules instructed by spontaneous activity. Recent studies show that experiences also modify innervation patterns bulb, especially during critical period This review examines evidence field suggest potential mechanisms which various aspects neural regulate targeting. We discuss precise functions served plasticity period.

Language: Английский

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Impact of diesel particulate matter on the olfactory bulb of mice: insights from behavioral, histological, and molecular assessments

Molecular & Cellular Toxicology, Journal Year: 2023, Volume and Issue: 20(3), P. 735 - 745

Published: Dec. 1, 2023

Language: Английский

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Early corticosteroid treatment enhances recovery from SARS-CoV-2 induced loss of smell in hamster

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 118, P. 78 - 89

Published: Feb. 15, 2024

Among the numerous long COVID symptoms, olfactory dysfunction persists in ∼10 % of patients suffering from SARS-CoV-2 induced anosmia. few potential therapies, corticoid treatment has been used for its anti-inflammatory effect with mixed success patients. In this study, we explored impact using hamster as an animal model. infected hamsters lose their smell abilities and loss is correlated damage epithelium persistent presence innate immunity cells. We started a dexamethasone 2 days post infection, when olfaction was already impacted, until 11 infection it to recover. observed improvement capacities animals treated compared those vehicle. This recovery not related differences remaining epithelium, which similar both groups. however reduced inflammation local increase mature neuron population. Surprisingly, at increased disorganized immature neurons, especially inflammatory zones epithelium. unusual population neurons coincided strong proliferation Our results indicate that following may alter extent speed regeneration population, effective limit improve infection.

Language: Английский

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Hair from sexually active bucks strongly activates olfactory sensory inputs but fails to trigger early first ovulation in prepubescent does

Physiology & Behavior, Journal Year: 2024, Volume and Issue: 275, P. 114451 - 114451

Published: Jan. 3, 2024

Language: Английский

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Dimethyl Fumarate Alleviates Adult Neurogenesis Disruption in Hippocampus and Olfactory Bulb and Spatial Cognitive Deficits Induced by Intracerebroventricular Streptozotocin Injection in Young and Aged Rats

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(24), P. 15449 - 15449

Published: Dec. 7, 2022

The disorder of adult neurogenesis is considered an important mechanism underlying the learning and memory impairment observed in Alzheimer's disease (AD). sporadic nonhereditary form AD (sAD) affects over 95% patients related to interactions between genetic environmental factors. An intracerebroventricular injection streptozotocin (STZ-ICV) a representative well-established method induce sAD-like pathology. Dimethyl fumarate (DMF) has antioxidant anti-inflammatory properties used for multiple sclerosis treatment. present study determines whether 26-day DMF therapy ameliorates disruption BDNF-related neuroprotection hippocampus olfactory bulb (OB) STZ-ICV rat model sAD. Considering age as risk factor developing AD, this was performed using 3-month-old (the young group) 22-month-old aged male Wistar rats. Spatial cognitive functions were evaluated with Morris water maze task. Immunofluorescent labelling assess parameters OB. Our results showed that evoked spatial disturbances BDNF expression both examined brain structures. In animals, deficits more severe. We found treatment significantly alleviated STZ-ICV-induced behavioural neuronal disorders groups findings suggest DMF, due its beneficial effect on formation new neurons neuroprotection, may be promising therapeutic agent human

Language: Английский

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The role of a ciliary GTPase in the regulation of neuronal maturation of olfactory sensory neurons

Development, Journal Year: 2023, Volume and Issue: 150(2)

Published: Jan. 15, 2023

ABSTRACT Olfactory sensory neurons (OSNs) form embryonically and mature perinatally, innervating glomeruli extending dendrites with multiple cilia. This process its timing are crucial for odor detection perception continues throughout life. In the olfactory epithelium (OE), differentiated OSNs proceed from an immature (iOSN) to a (mOSN) state through well-defined sequential morphological molecular transitions, but precise mechanisms controlling OSN maturation remain largely unknown. We have identified that GTPase, ARL13B, has transient state-dependent expression in marking emergence of primary cilium. Utilizing iOSN-specific Arl13b-null murine model, we examined role ARL13B OSNs. The loss Arl13b iOSNs caused profound dysregulation cellular homeostasis development OE. Importantly, null demonstrated delay their maturation. Finally, resulted severe deformation structure innervation glomeruli. Our findings demonstrate previously unknown

Language: Английский

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