Herein,
we
presented
a
practical
methodology
for
the
intermolecular
aziridination
of
alkenes,
using
HOSA
as
aminating
agent,
alongside
pyridine
or
piperidine
base,
within
HFIP
solvent
system.
Notably,
this
approach
showcases
excellent
reactivity,
especially
with
non-activated
and
facilitates
transformation
various
alkenes
substrates,
including
mono-,
di-,
tri,
tetra-substituted
into
aziridines
moderate
to
yield.
This
method
presents
promising
avenue
synthesizing
from
wide
range
featuring
benefits
straightforward
operation,
mild
reaction
conditions,
extensive
substrate
compatibility,
scalability.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
63(5)
Published: Dec. 7, 2023
A
mechanochemical
synthesis
of
sulfonimidamides
by
iron(II)-catalyzed
exogenous
ligand-free
N-acyl
nitrene
transfer
to
sulfinamides
is
reported.
The
one-step
method
tolerates
a
wide
range
with
various
substituents
under
solvent-free
ambient
conditions.
Compared
its
solution-phase
counterpart,
this
approach
shows
better
conversion
and
chemoselectivity.
Mechanistic
investigations
ESI-MS
revealed
the
generation
crucial
iron
intermediates.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(4), P. 1998 - 1998
Published: Feb. 20, 2023
Dichalcogenides
(disulfides
and
diselenides),
as
reactants
for
organic
transformations,
are
important
widely
used
because
of
their
potential
to
react
with
nucleophiles,
electrophilic
reagents,
radical
precursors.
In
recent
years,
in
combination
photochemical
technology,
the
application
dichalcogenides
stable
reagents
has
opened
up
a
new
route
synthesis
various
sulfur-
selenium-containing
compounds.
this
paper,
synthetic
strategies
disulfides
diselenides
applications
technology
reviewed:
(i)
Cyclization
alkenes
alkynes;
(ii)
direct
selenylation/sulfuration
C−H/C−C/C−N
bonds;
(iii)
visible-light-enabled
seleno-
sulfur-bifunctionalization
alkenes/alkynes;
(iv)
Direct
construction
C(sp)–S
bond.
addition,
scopes,
limitations,
mechanisms
some
reactions
also
described.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(8), P. 2070 - 2074
Published: Jan. 1, 2023
Acid-catalyzed
disulfuration
and
rearrangement
have
been
disclosed
for
the
construction
of
alkynyl
or
acyl
disulfides
from
thiols
N
-alkynylthio
phthalimides,
enabling
access
to
disulfide-modified
thiodrugs,
thiopeptides
thioglycosides.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(41), P. 22639 - 22648
Published: Oct. 3, 2023
Disulfide
bonds
are
widely
found
in
natural
peptides
and
play
a
pivotal
role
stabilizing
their
secondary
structures,
which
highly
associated
with
biological
functions.
Herein,
we
introduce
light-mediated
strategy
to
effectively
control
the
formation
of
disulfides.
Our
is
based
on
2-nitroveratryl
(oNv),
used
photolabile
motif,
serves
both
as
photocaging
group
an
oxidant
(after
photolysis).
We
demonstrated
that
irradiation
oNv-caged
thiols
UV
light
could
release
free
rapidly
oxidized
by
locally
released
byproduct
nitrosoarene,
leading
"break-to-bond"
fashion.
This
highlighted
situ
restoration
antimicrobial
peptide
tachyplesin
I
(TPI)
from
its
external
disulfide-caged
analogue
TPI-1.
TPI-1
exhibits
distorted
structure
diminished
function.
However,
upon
irradiation,
β-hairpin
membrane
activity
TPI
were
largely
restored
via
rapid
intramolecular
disulfide
formation.
study
proposes
powerful
method
regulate
conformation
function
spatiotemporal
manner,
has
significant
potential
for
design
disulfide-centered
light-responsive
systems.
Herein,
we
presented
a
practical
methodology
for
the
intermolecular
aziridination
of
alkenes,
using
HOSA
as
aminating
agent,
alongside
pyridine
or
piperidine
base,
within
HFIP
solvent
system.
Notably,
this
approach
showcases
excellent
reactivity,
especially
with
non-activated
and
facilitates
transformation
various
alkenes
substrates,
including
mono-,
di-,
tri,
tetra-substituted
into
aziridines
moderate
to
yield.
This
method
presents
promising
avenue
synthesizing
from
wide
range
featuring
benefits
straightforward
operation,
mild
reaction
conditions,
extensive
substrate
compatibility,
scalability.
