Advanced Science,
Journal Year:
2024,
Volume and Issue:
12(2)
Published: Nov. 21, 2024
Abstract
Endogenous
stimuli‐responsive
prodrugs,
due
to
their
disease
lesion
specificity
and
reduced
systemic
toxicity,
have
been
widely
explored
for
antitumor
therapy.
However,
reactive
oxygen
species
(ROS)
as
classical
endogenous
stimuli
in
the
tumor
microenvironment
(TME)
are
not
enough
achieve
expected
drug
release.
Herein,
a
ROS‐activatable
heterodimeric
prodrug‐loaded
enzyme
assembly
is
developed
self‐boosting
programmable
release
of
multiple
therapeutic
agents.
The
prodrug
NBS‐TK‐PTX
(namely
NTP)
composed
5‐(ethylamino)‐9‐diethylaminobenzo[
]phenothiazinium
chloride
analog
(NBS),
paclitaxel
(PTX)
ROS‐responsive
thioketal
(TK)
linker,
which
shows
strong
binding
affinity
with
glucose
oxidase
(GOx),
thus
obtaining
NTP@GOx
assembly.
Notably,
enzymatic
activity
GOx
inhibited
by
NTP.
achieved
following
steps:
i)
partially
dissociated
acidic
TME,
releasing
small
segment
NTP
GOx.
Thereupon,
recovered;
ii)
GOx‐triggered
pH
reduction
further
facilitates
dissociation
NTP@GOx,
accelerating
large
amount
release;
iii)
TK
linker
cleaved
hydrogen
peroxide
generated
catalysis,
expediting
NBS
Type‐I
photodynamic
therapy
PTX
chemotherapy,
respectively.
great
potential
multimodal
synergistic
cancer
Medicina,
Journal Year:
2024,
Volume and Issue:
60(2), P. 228 - 228
Published: Jan. 28, 2024
Cancer
is
one
of
the
leading
causes
death
in
world.
Various
drugs
have
been
developed
to
eliminate
it
but
no
avail
because
a
tumor
can
go
into
dormancy
avoid
therapy.
In
past
few
decades,
has
become
popular
topic
cancer
Recently,
there
an
important
breakthrough
study
dormancy.
That
is,
cells
enter
reversible
drug-tolerant
persister
(DTP)
state
therapy,
exact
mechanism
found.
The
link
between
DTP
and
diapause
seems
provide
opportunity
for
correct
understanding
state.
Completely
treating
avoiding
by
targeting
expression
key
genes
are
possible.
This
review
delves
characteristics
its
connection
with
embryonic
diapause,
possible
treatment
strategies
summarized.
authors
believe
that
this
will
promote
development
Cancers,
Journal Year:
2024,
Volume and Issue:
16(15), P. 2622 - 2622
Published: July 23, 2024
Colorectal
cancer
(CRC)
represents
a
significant
global
healthcare
burden,
with
particularly
concerning
rising
incidence
among
younger
adults.
This
trend
may
highlight
potential
links
between
diet,
gut
microbiome,
and
CRC
risk.
Novel
therapeutic
options
have
been
increasingly
based
on
the
understanding
of
molecular
mechanisms
pathways.
The
PI3K/AKT/mTOR
pathway,
crucial
cell
growth
regulator,
offers
promising
target
for
therapy.
mTOR,
key
component
within
this
controls
growth,
survival,
metabolism.
Understanding
specific
roles
defensins,
human
β-Defensin
1
(HBD-1),
in
is
crucial.
HBD-1
exhibits
potent
antimicrobial
activity
influence
development.
Deciphering
defensin
expression
patterns
holds
promise
improved
tumorigenesis,
which
pave
way
diagnostics
therapies.
article
reviews
recent
advances
regarding
how
influences
initiation
progression,
highlighting
by
it
impacts
CRC.
Further,
we
describe
interaction
defensins
mTOR
pathway
Advanced Science,
Journal Year:
2024,
Volume and Issue:
12(2)
Published: Nov. 21, 2024
Abstract
Endogenous
stimuli‐responsive
prodrugs,
due
to
their
disease
lesion
specificity
and
reduced
systemic
toxicity,
have
been
widely
explored
for
antitumor
therapy.
However,
reactive
oxygen
species
(ROS)
as
classical
endogenous
stimuli
in
the
tumor
microenvironment
(TME)
are
not
enough
achieve
expected
drug
release.
Herein,
a
ROS‐activatable
heterodimeric
prodrug‐loaded
enzyme
assembly
is
developed
self‐boosting
programmable
release
of
multiple
therapeutic
agents.
The
prodrug
NBS‐TK‐PTX
(namely
NTP)
composed
5‐(ethylamino)‐9‐diethylaminobenzo[
]phenothiazinium
chloride
analog
(NBS),
paclitaxel
(PTX)
ROS‐responsive
thioketal
(TK)
linker,
which
shows
strong
binding
affinity
with
glucose
oxidase
(GOx),
thus
obtaining
NTP@GOx
assembly.
Notably,
enzymatic
activity
GOx
inhibited
by
NTP.
achieved
following
steps:
i)
partially
dissociated
acidic
TME,
releasing
small
segment
NTP
GOx.
Thereupon,
recovered;
ii)
GOx‐triggered
pH
reduction
further
facilitates
dissociation
NTP@GOx,
accelerating
large
amount
release;
iii)
TK
linker
cleaved
hydrogen
peroxide
generated
catalysis,
expediting
NBS
Type‐I
photodynamic
therapy
PTX
chemotherapy,
respectively.
great
potential
multimodal
synergistic
cancer
