Heliyon, Journal Year: 2024, Volume and Issue: unknown, P. e36742 - e36742
Published: Sept. 1, 2024
Microbiological Research, Journal Year: 2023, Volume and Issue: 274, P. 127432 - 127432
Published: June 8, 2023
Language: Английский
Citations
48
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Feb. 29, 2024
Early-life human gut microbiome is a pivotal driver of homeostasis and infant health. However, the viral component (known as "virome") remains mostly unexplored. Here, we establish Early-Life Gut Virome (ELGV), catalog 160,478 non-redundant DNA RNA sequences from 8130 virus-like particles (VLPs) enriched or bulk metagenomes in first three years life. By clustering, 82,141 species are identified, 68.3% which absent existing databases built mainly adults, 64 8 based on VLPs-enriched metagenomes, respectively, exhibit potentials biomarkers to distinguish infants adults. With largest longitudinal population profiled by either metagenomic sequencing, track inherent instability temporal development early-life virome, identify differential viruses associated with multiple clinical factors. The mother-infant shared virome interactions between bacteriome early life further expanded. Together, ELGV provides most comprehensive complete blueprint facilitating discovery pediatric disease-virome associations future.
Language: Английский
Citations
17
Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(4), P. 833 - 845
Published: Aug. 14, 2023
A growing body of evidence suggests that the gut microbiota contributes to development neurodegenerative diseases via microbiota-gut-brain axis. As a contributing factor, dysbiosis always occurs in pathological changes diseases, such as Alzheimer's disease, Parkinson's and amyotrophic lateral sclerosis. High-throughput sequencing technology has helped reveal bidirectional communication between central nervous system enteric is facilitated by microbiota's diverse microorganisms, for both neuroimmune neuroendocrine systems. Here, we summarize bioinformatics analysis wet-biology validation metagenomics with an emphasis on multi-omics studies virome. The pathogen-associated signaling biomarkers identifying brain disorders potential therapeutic targets are also elucidated. Finally, discuss role diet, prebiotics, probiotics, postbiotics exercise interventions remodeling microbiome reducing symptoms diseases.
Language: Английский
Citations
29
Nature Microbiology, Journal Year: 2023, Volume and Issue: 8(11), P. 2170 - 2182
Published: Sept. 25, 2023
Language: Английский
Citations
27
Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17
Published: March 21, 2023
Stroke-induced depression is a common complication and an important risk factor for disability. Besides psychiatric symptoms, depressed patients may also exhibit variety of gastrointestinal even take symptoms as the primary reason medical treatment. It well documented that stress disrupt balance gut microbiome in suffering from post-stroke (PSD), disruption closely related to severity condition patients. Therefore, maintaining intestinal microbiota can be focus research on mechanism acupuncture treatment PSD. Furthermore, stroke effectively treated with at all stages it act special microecological regulator by regulating well. In this article, we reviewed studies changing after examined existing problems development prospects acupuncture, microbiome, poststroke depression, order provide new ideas future research.
Language: Английский
Citations
26
Life, Journal Year: 2023, Volume and Issue: 13(8), P. 1765 - 1765
Published: Aug. 18, 2023
The microbiota inhabits the gastrointestinal tract, providing essential capacities to host. is a crucial factor in intestinal health and regulates physiology. However, disturbances, named dysbiosis, can disrupt homeostasis, leading development of diseases. Classically, has been referred as bacteria, though other organisms form this complex group, including viruses, archaea, eukaryotes such fungi protozoa. This review aims clarify role helminths, bacteriophages, fungi, archaea homeostasis diseases, their interaction with use therapeutic targets maladies.
Language: Английский
Citations
16
microLife, Journal Year: 2024, Volume and Issue: 5
Published: Jan. 1, 2024
Archaeal viruses display a high degree of structural and genomic diversity. Few details are known about the mechanisms by which these enter exit their host cells. Research on archaeal has lately made significant progress due to advances in genetic tools imaging techniques, such as cryo-electron tomography (cryo-ET). In recent years, steady output newly identified viral receptors egress offered first insight into how interact with cell envelope. As more entry unravelled, patterns starting emerge. This helps better understand interactions between envelope compare infection strategies other domains life. Here, we provide an overview developments field egress, shedding light onto most elusive part virosphere.
Language: Английский
Citations
5
Biosafety and Health, Journal Year: 2024, Volume and Issue: 6(2), P. 101 - 115
Published: March 2, 2024
Chicken is an important food animal worldwide and plays role in human life by providing meat eggs. Despite recent significant advances gut microbiome studies, a comprehensive study of chicken bacterial, archaeal, viral genomes remains unavailable. In this study, we constructed multi-kingdom catalog (CMKMC), including 18,201 225 33,411 genomes, annotated over 6,076,006 protein-coding genes integrating 135 metagenomes publicly available metagenome-assembled (MAGs) from ten countries. We found that 812 240 MAGs our dataset were putative novel species genera, respectively, far beyond what was previously reported. The newly unclassified predominant Phyla Firmicutes_A (n = 263), followed Firmicutes 126), Bacteroidota 121), Proteobacteria 87). Most the classified species-level operational taxonomic units belong to Caudovirales. Approximately, 63.24 % viromes are predicted infect two or more hosts, complete circular viruses. Moreover, diverse auxiliary metabolic antibiotic resistance carried Together, CMKMC provides largest integrated date, functional insights into gastrointestinal tract microbiota, paves way for microbial interventions better health productivity.
Language: Английский
Citations
5
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Dec. 20, 2024
Abstract CRISPR-based gene editing technology theoretically allows for precise manipulation of any genetic target within living cells, achieving the desired sequence modifications. This revolutionary advancement has fundamentally transformed field biomedicine, offering immense clinical potential treating and correcting disorders. In treatment most diseases, genome that avoids generation mixed byproducts is considered ideal approach. article reviews current progress base editors prime editors, elaborating on specific examples their applications in therapeutic field, highlights opportunities improvement. Furthermore, we discuss performance these technologies terms safety efficacy applications, analyze latest advancements directions could influence future development technologies. Our goal to outline relevance this rapidly evolving scientific preview a roadmap successful DNA therapies hereditary or idiopathic diseases.
Language: Английский
Citations
5
Cancer Immunology Immunotherapy, Journal Year: 2025, Volume and Issue: 74(2)
Published: Jan. 3, 2025
We focused on how the immunophenotypes based distribution of CD8-positive tumor-infiltrating lymphocytes (TILs) relate to endometrial cancer (EC) molecular subtypes and patients' prognosis.
Language: Английский
Citations
0