Marginated aberrant red blood cells induce pathologic vascular stress fluctuations in a computational model of hematologic disorders DOI Creative Commons
Xiaopo Cheng, Christina Caruso, Wilbur A. Lam

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 18, 2023

Red blood cell (RBC) disorders affect billions worldwide. While alterations in the physical properties of aberrant RBCs and associated hemodynamic changes are readily observed, conditions such as sickle disease iron deficiency, RBC can also be with vascular dysfunction. The mechanisms vasculopathy those diseases remain unclear scant research has explored whether biophysical directly function. Here we hypothesize that purely interactions between endothelial cells, due to margination stiff RBCs, play a key role this phenomenon for range disorders. This hypothesis is tested by direct simulations cellular scale computational model flow disease, deficiency anemia, COVID-19, spherocytosis. We characterize distributions normal mixtures straight curved tubes, latter address issues geometric complexity arise microcirculation. In all cases strongly localize near vessel walls (margination) contrasts size, shape, deformability from cells. channel, distribution marginated cells very heterogeneous, indicating geometry. Finally, shear stresses on walls; consistent our hypothesis, generate large transient stress fluctuations high velocity gradients induced their near-wall motions. anomalous experienced may responsible observed inflammation.

Language: Английский

Marginated aberrant red blood cells induce pathologic vascular stress fluctuations in a computational model of hematologic disorders DOI Creative Commons
Xiaopo Cheng, Christina Caruso, Wilbur A. Lam

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 18, 2023

Red blood cell (RBC) disorders affect billions worldwide. While alterations in the physical properties of aberrant RBCs and associated hemodynamic changes are readily observed, conditions such as sickle disease iron deficiency, RBC can also be with vascular dysfunction. The mechanisms vasculopathy those diseases remain unclear scant research has explored whether biophysical directly function. Here we hypothesize that purely interactions between endothelial cells, due to margination stiff RBCs, play a key role this phenomenon for range disorders. This hypothesis is tested by direct simulations cellular scale computational model flow disease, deficiency anemia, COVID-19, spherocytosis. We characterize distributions normal mixtures straight curved tubes, latter address issues geometric complexity arise microcirculation. In all cases strongly localize near vessel walls (margination) contrasts size, shape, deformability from cells. channel, distribution marginated cells very heterogeneous, indicating geometry. Finally, shear stresses on walls; consistent our hypothesis, generate large transient stress fluctuations high velocity gradients induced their near-wall motions. anomalous experienced may responsible observed inflammation.

Language: Английский

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