Fructose-Induced Metabolic Dysfunction Is Dependent on the Baseline Diet, the Length of the Dietary Exposure, and Sex of the Mice

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 124 - 124

Published: Dec. 31, 2024

Background/Objectives: High sugar intake, particularly fructose, is implicated in obesity and metabolic complications. On the other hand, fructose from fruits vegetables has undisputed benefits for health. This raises a paradoxical question—how same molecule can be associated with detrimental health effects some studies beneficial others. study investigates how diet sex interact to modulate outcomes. Methods: Male female mice were fed different normal chow diets, Boston (BCD; 23% protein, 22% fat, 55% carbohydrates), Lexington (LXD; 24% 18% 58% low-fat (LFD; 20% 10% 70% supplemented 30% water. Results: Fructose-supplemented male on BCD gained weight developed glucose intolerance hepatic steatosis. Conversely, given LXD did not gain weight, remained glucose-tolerant, had lipid content. Furthermore, fructose-fed LFD weight. However, upon switching BCD, they exhibited worsening liver steatosis, advanced insulin resistance. The of are sex-dependent. Thus, insulin-sensitive supplementation despite developing These differences outcomes correlate propensity baseline suppress ketohexokinase expression de novo lipogenesis pathway. likely driven by dietary fat-to-carbohydrate ratio. Conclusions: Metabolic dysfunction attributed intake universal outcome. Instead, it depends diet, exposure length, sex.

Language: Английский

Low-Fat, High-Carbohydrate Diets Reduce Body Weight and Sperm Count but Increase Sperm Motility in Mice

Journal of Nutrition, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 1, 2023

Language: Английский

Diet composition during the early post‐nursing period: in male mice, macronutrients matter

The Journal of Physiology, Journal Year: 2023, Volume and Issue: 601(21), P. 4657 - 4658

Published: Sept. 18, 2023

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Language: Английский