Mitochondrial fission – changing perspectives for future progress

Journal of Cell Science, Journal Year: 2025, Volume and Issue: 138(9)

Published: March 19, 2025

ABSTRACT Mitochondrial fission is important for many aspects of cellular homeostasis, including mitochondrial distribution, stress response, mitophagy, mitochondrially derived vesicle production and metabolic regulation. Several decades research has revealed much about fission, identification a key division protein – the dynamin Drp1 (also known as DNM1L) receptors on outer membrane (OMM), Mff, MiD49 MiD51 MIEF2 MIEF1, respectively) Fis1, regulators, post-translational modifications, actin filaments phospholipid cardiolipin. In addition, it now appreciated that other organelles, endoplasmic reticulum, lysosomes Golgi-derived vesicles, can participate in fission. However, more holistic understanding process lacking. this Review, we address three questions highlight knowledge gaps. First, how do quantify fission? Second, does inner (IMM) divide? Third, ‘types’ exist? We also introduce model integrates multiple regulatory factors mammalian model, possible pathways (cellular stimulation, switching or dysfunction) independently initiate recruitment at site, followed by shared second step which Mff mediates subsequent assembly contractile ring. conclude discussing some perplexing issues regulation, effects phosphorylation isoforms.

Language: Английский

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Infectious viruses and neurodegenerative diseases: The mitochondrial defect hypothesis

Reviews in Medical Virology, Journal Year: 2024, Volume and Issue: 34(4)

Published: June 21, 2024

Abstract Global attention is riveted on neurodegenerative diseases due to their unresolved aetiologies and lack of efficacious therapies. Two key factors implicated include mitochondrial impairment microglial ageing. Several viral infections, including Herpes simplex virus‐1 (HSV‐1), human immunodeficiency virus (HIV) Epstein‐Barr virus, are linked heightened risk these disorders. Surprisingly, numerous studies indicate viruses induce aforementioned precipitating events. Hepatitis C Virus, HIV, respiratory syncytial HSV‐1, Japanese Encephalitis Zika Enterovirus 71 specifically impact function, leading malfunction. These vital organelles govern various cell activities and, under specific circumstances, trigger This article explores the role infections in elucidating pathogenesis ailments. Various instigate ageing via destruction, causing senescent microglia exhibit activated behaviour, thereby inducing neuroinflammation contributing neurodegeneration.

Language: Английский

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l-Glutamic Acid Alleviates Mastitis in Dairy Cows by Targeting the Sirt5/Nrf2/Prdx1 Signaling Axis and Mitochondrial Function

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Mastitis in dairy cows is an inflammatory disease that severely affects the health and lactation functions of cows. Mitochondrial damage closely related to response. How effectively alleviate mitochondrial key preventing treating mastitis In this study, we found elevated levels response accompanied by reduced expression Sirt5 (Sirtuin5) with compared healthy This suggests plays important role Subsequently, further analyzed mammary gland tissue from untargeted metabolomics (LC-MS/MS) screened for differential metabolite l-glutamic acid (l-Glu). To validate effect l-Glu on cows, conducted a study using MAC-T cells. The results showed was able ameliorate LPS-induced activating promoting fusion upregulation membrane potential (MMP) levels. contrast, unable protect function after knocking down Sirt5. Furthermore, upregulate nuclear factor E2-related (Nrf2) peroxiredoxin 1 (Prdx1) cells, promoted entry Nrf2 into nucleus, which reversed Next, explored whether alleviates through Nrf2/Prdx1 signaling axis inhibitor RA. use RA blocked protective function. conclusion, ameliorates targeting activate provides new target theoretical basis clinical control mastitis. could be added as dietary supplement diets maintain homeostasis, thereby protecting economic value

Language: Английский

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MG53 Deficiency Mediated Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease Via Impairing Mitochondrial Dynamics

Published: Jan. 1, 2025

Language: Английский

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FIS1 alleviates neuropathic pain by inhibiting mitochondrial fragmentation

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Although neuropathic pain leads to abnormal mitochondrial fission in neurons, it remains unclear whether inhibiting has analgesic effects. This study focused on protein 1 (FIS1) investigate its role spared nerve injury (SNI)-induced and the underlying mechanisms. Using MiNA analysis, electron microscopy, membrane potential (MMP), reactive oxygen species (ROS), adenosine triphosphate (ATP) detection, we observed that networks both excitatory inhibitory neurons of spinal dorsal horn (SDH) were disrupted SNI mice, as demonstrated through use specifically constructed GAD2-MITO vGluT2-MITO transgenic mouse models. Furthermore, down-regulating FIS1 but not could exert effects, using vGluT2-Cre mice GAD2-Cre mice. Third, epigallocatechin gallate (EGCG), which was capable horn, concurrently inhibited SNI-induced pain. The above results indicate SDH can alleviate by reducing fragmentation. In addition, improving dysfunction. Our research findings suggest may represent a novel molecular target for treatment

Language: Английский

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Excessive Mitochondrial Fission and Associated Extracellular Mitochondria Mediate Cardiac Dysfunction in Obesity Cardiomyopathy

Published: Jan. 1, 2025

Language: Английский

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Inhibition of Drp1-mediated mitochondrial fission by P110 ameliorates renal injury in diabetic nephropathy

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114342 - 114342

Published: March 3, 2025

Language: Английский

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Nutritional Interventions in Amyotrophic Lateral Sclerosis: From Ketogenic Diet and Neuroprotective Nutrients to the Microbiota-Gut-Brain Axis Regulation

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Language: Английский

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DRP1, fission and apoptosis

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 7, 2025

Language: Английский

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Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Oct. 12, 2023

Ensuring mitochondrial quality is essential for maintaining neuronal homeostasis, and transport plays a vital role in control. In this review, we first provide an overview of transport, followed by detailed description the various motors adaptors associated with anterograde retrograde mitochondria. Subsequently, review modest evidence involving mechanisms that has surfaced acute neurological disorders, including traumatic brain injury, spinal cord spontaneous intracerebral hemorrhage, ischemic stroke. An in-depth study area will help deepen our understanding underlying development disorders ultimately improve therapeutic options.

Language: Английский

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