Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(10), P. 2075 - 2080
Published: Jan. 1, 2024
Direct
C(sp
3
)-H
selenation,
which
is
most
atom
economical,
remains
a
formidable
challenge,
and
only
few
examples
have
been
reported
to
date.
In
this
article,
we
introduce
the
transition
metal-free
selenation
with
β-ketosulfones
diselenides
as
material
source.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(44), P. 9586 - 9591
Published: Oct. 29, 2024
Herein,
we
describe
the
development
and
application
of
a
novel
benzotriazole-based
reagent
toward
radical
trifluoroethoxylation.
Various
alkene
classes,
including
styrene
derivatives,
enol
carbonates,
allyl
silanes,
are
viable
reaction
partners
in
this
transformation,
yielding
diverse
trifluoroethoxylated
products.
Furthermore,
method
is
readily
applicable
for
late-stage
modification
natural
product
drugs
molecules.
Mechanistic
computational
studies
suggest
intermediacy
an
OCH2CF3
generated
under
photocatalytic
conditions.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(16), P. 11682 - 11692
Published: Aug. 1, 2024
Alkene
difunctionalization
is
a
very
attractive
tool
in
synthetic
organic
chemistry.
Herein,
we
disclose
an
operationally
and
practically
simple
method
to
access
2-hydroxytrifluoroethylacetophenones
from
styrene
derivatives
via
photoredox
catalysis.
This
light-mediated
transformation
promotes
the
generation
of
1-hydroxy-2,2,2-trifluoroethyl
carbon-centered
radical
as
key
synthon,
which
undergoes
Giese
addition
with
styrenes
followed
by
Kornblum
oxidation
process.
The
presented
not
only
mild
cost-effective,
but
also
utilizes
photocatalyst
DMSO
oxidant.
Experimental
investigations
support
operative
mechanism
net-neutral
radical/polar
crossover.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(19), P. 14691 - 14716
Published: Jan. 1, 2025
Transition
metal-free
benzylic
C(sp
3
)–H
activation
is
a
direct
strategy
for
forming
C–C
and
C–X
bonds.
This
review
highlights
C–H
activation/annulation
or
activation/functionalization
of
toluenes
using
non-metal
catalysts
promoters.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(31)
Published: June 17, 2024
Abstract
In
this
study,
a
novel
approach
for
the
tertiary
α‐alkylation
of
ketones
using
alkanes
with
electron‐deficient
C─H
bonds
is
presented,
employing
synergistic
catalytic
system
combining
inexpensive
copper
salts
aminocatalysis.
This
methodology
addresses
limitations
traditional
alkylation
methods,
such
as
need
strong
metallic
bases,
regioselectivity
issues,
and
risk
over
alkylation,
by
providing
high
reactivity
chemoselectivity
without
necessity
pre‐functionalized
substrates.
The
dual
strategy
enables
direct
functionalization
C(sp
3
)─H
bonds,
demonstrating
remarkable
selectivity
in
presence
conventional
that
are
adjacent
to
heteroatoms
or
π
systems,
which
typically
susceptible
single‐electron
transfer
processes.
findings
contribute
advancement
techniques,
offering
practical
efficient
route
construction
)─C(sp
)
paving
way
further
developments
synthesis
complex
organic
molecules.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 24, 2024
Abstract
Dearomatization
of
arenes
emerges
as
a
reliable
strategy
for
crafting
intricate
3D
polycyclic
frameworks.
Nonetheless,
the
development
an
efficient
method
dearomatization
across
diverse
remains
formidable
challenge,
particularly
in
case
unactivated
benzene.
In
this
study,
we
present
facile
dearomative
difunctionalization
approach
through
highly
selective
radical
relay
reaction.
The
reaction
operates
under
mild
conditions,
devoid
metals,
photocatalysts,
and
additives.
This
exhibits
broad
substrate
scope
exceptional
functional
group
tolerance,
successfully
transforming
various
aromatics,
including
inert
naphthalene
benzene
rings,
indoles,
pyrroles,
benzofuran,
thiophene.
Bioactivity
assessments
reveal
significant
inhibitory
effect
synthesized
complex
frameworks
on
HCT
116
cancer
cells,
with
subsequent
mouse
experiments
providing
compelling
evidence
its
feasibility.
