Electrochemical demethoxyl-cyanation of methoxyarenes via SNAr DOI
Suming Chen,

Anzai Shi,

Guoqing Yang

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110810 - 110810

Published: Dec. 1, 2024

Language: Английский

Electrochemical Oxidative Cascade Cyclization of Alkenyl Alcohols with External Nucleophiles to Access Amino- and Hydroxy-Functionalized O-Heterocycles DOI

Liang-Chen Ren,

Min Wang, Xiao Zha

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

A convenient electrochemical oxidative cascade cyclization of alkenes equipped with pendant alcohols general nucleophiles was developed. Using readily available diarylmethanimine and carboxylic acids as nucleophilic sources, a broad range internal alkene terminal substrates could produce RCO2- Ar2CN-functionalized O-heterocycles in moderate to high yields without the requirement for external oxidants metals. These resulting products can subsequently be hydrolyzed yield valuable NH2- OH-functionalized tetrahydrofurans tetrahydropyranes under mild conditions. Importantly, efficient conversion secondary alcohol amines complete inversion configuration enhances methodology, enabling construction 2-aryl-3-amino tetrahydrofuran complementary diastereoselectivity.

Language: Английский

Citations

0
Electrochemical demethoxyl-cyanation of methoxyarenes via SNAr DOI
Suming Chen,

Anzai Shi,

Guoqing Yang

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110810 - 110810

Published: Dec. 1, 2024

Language: Английский

Citations

0