The malic acid inhibiting inflammation in ankylosing spondylitis by interfering M1 macrophage polarization DOI Creative Commons

Zhou Ji,

Xinzhe Feng,

Changhao Han

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113653 - 113653

Published: Nov. 19, 2024

Ankylosing spondylitis (AS) is a motor system immune disease with significant genetic characteristics, resulting in joint fusion, deformity, rigidity, seriously affecting the quality of life patients. Inflammatory bowel (IBD), characterized by intestinal mucosal damage and inflammatory changes, most common extra-articular manifestation AS. Due to limitations application therapeutic drugs, it urgent look for new mechanisms strategies effectively inhibit AS inflammation is. The content malic acid (MA) was significantly decreased peripheral blood patients, negatively correlated C-reactive protein (CRP) erythrocyte sedimentation rate (ESR). MA dramatically alleviated spinal mouse models induced β-1, 3-glucan solution. Mechanically, suppressed NF-κB pathway inhibiting polarization M1-type macrophages, thereby alleviating inflammation. From perspective material metabolism, this study explored mechanism which MA, an intermediate product glucose reducing M1 macrophages inflammation, providing reliable basis pathogenesis research precise targeted treatment later stage.

Language: Английский

FSH exacerbates bone loss by promoting osteoclast energy metabolism through the CREB-MDH2-NAD+ axis DOI

Jingqiu Chen,

Yilin Liao, Yue Sheng

et al.

Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 156147 - 156147

Published: Jan. 1, 2025

Language: Английский

Citations

2
Current applications of intestinal organoids: a review DOI Creative Commons
Tao Xiang, Jie Wang, Hui Li

et al.

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 31, 2024

In the past decade, intestinal organoid technology has paved way for reproducing tissue or organ morphogenesis during physiological processes in vitro and studying pathogenesis of various diseases. Intestinal organoids are favored drug screening due to their ability high-throughput cultivation closer resemblance patient genetic characteristics. Furthermore, as disease models, find wide applications diagnostic markers, identifying therapeutic targets, exploring epigenetic mechanisms Additionally, a transplantable cellular system, have played significant role reconstruction damaged epithelium conditions such ulcerative colitis short bowel syndrome, well material exchange metabolic function restoration. The rise interdisciplinary approaches, including organoid-on-chip technology, genome editing techniques, microfluidics, greatly accelerated development organoids. this review, VOSviewer software is used visualize hot co-cited journal keywords trends firstly. Subsequently, we summarized current modeling, screening, regenerative medicine. This will deepen our understanding further explore intestine

Language: Английский

Citations

8
Capillary electrochromatography synergistic enantioseparation system for racemate malic acid based on a novel nanomaterial synthesized by chiral molecularly imprinted polymer and chiral metal-organic framework DOI

Pandeng Miao,

Yifan Yan,

Shuaijing Du

et al.

Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1330, P. 343303 - 343303

Published: Oct. 4, 2024

Language: Английский

Citations

4
Tenascin-C promotes bone regeneration via inflammatory macrophages DOI Creative Commons

Qian Ren,

Wenhui Xing, Bo Jiang

et al.

Cell Death and Differentiation, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract During the early stage of tissue injury, macrophages play important roles in activation stem cells for further regeneration. However, regulation during bone regeneration remains unclear. Here, extracellular matrix (ECM) tenascin-C (TNC) is found to express periosteum and recruit inflammatory macrophages. TNC-deficiency delays repair. Transplantation derived from injured able rescue decreased skeletal impaired caused by TNC deficiency. The cell communication analysis identifies ITGA7 as a receptor contributing recruitment expression declines aged mice exogenous delivery significantly promotes after aging through Taken together, this study reveals macrophage its function providing strategy accelerate delivery.

Language: Английский

Citations

0
High Expression of SERPINE1 and CTSL in Keratinocytes in Pressure Injury Caused by Ischemia-reperfusion Injury DOI
Liangjia Bi, Yaxin Liu, Lei Zhang

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: 93, P. 102746 - 102746

Published: Jan. 22, 2025

Language: Английский

Citations

0
Dietary addition of compound organic acids improves the growth performance, carcass trait, and body health of broilers DOI Creative Commons

Fang Cai,

Mingyuan Huang, Wei Liu

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 28, 2025

Introduction The poultry industry constantly seeks strategies to enhance broiler growth performance and overall health. Organic acidifiers, including L-lactic acid, L-malic acetic have gained attention as potential feed additives improve animal production by modulating gut health, enhancing nutrient absorption, supporting immune function. Despite their promising effects in other species, the impact of this novel compound organic acidifier on performance, metabolism, response has not been fully elucidated. This study aims evaluate serum lipid profile, antioxidant status, parameters broilers, providing insights into its benefits a dietary supplement for health productivity. Methods A total 240 broilers were randomly divided four groups: control group three treatment groups receiving 0.25%, 0.5%, or 1.0% acidifier, with six replicates ten birds each. Over 6-week period, various measured, triglycerides, high-density lipoproteins, lysozyme, immunoglobulins (IgA, IgM), superoxide dismutase (SOD) activity, IL-2, TNF- α , gene expressions related metabolism. Results decreased triglycerides lipoproteins while also performance. Additionally, it raised levels IgA, IgM, SOD. IL-2 concentrations jejunum mucosa decreased. upregulated PPARα AMPK FABP1 MTTP expressions, downregulated APOB100 . Overall, effectively improved during early development phase primarily hepatic capacity, Conclusion These results suggest that may accelerate liver metabolism expression profiles involved

Language: Английский

Citations

0
Organoid models: applications and research advances in colorectal cancer DOI Creative Commons

Yijie Wu,

Sha Yu,

Xingpo Guo

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 7, 2025

This review summarizes the applications and research progress of organoid models in colorectal cancer research. First, high incidence mortality rates are introduced, emphasizing importance organoids as a model. Second, this provides detailed introduction to concept, biological properties, organoids, including their strengths mimicking structural functional aspects organs. article further analyzes adult stem cell-derived pluripotent discusses advancements for basic research, drug development, personalized treatment evaluation prediction, regenerative medicine. Finally, prospects applying technology its significant value improving patient survival rates. In conclusion, systematically explains highlighting tremendous potential promising

Language: Английский

Citations

0
The Use of Gut Organoids: To Study the Physiology and Disease of the Gut Microbiota DOI Creative Commons
Ya Deng, Xiaolu Yuan,

Xianmin Lu

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(4)

Published: Feb. 1, 2025

ABSTRACT The intestinal flora has attracted much attention in recent years. An imbalance the can cause not only diseases but also a variety of parenteral diseases, such as endocrine nervous system and cardiovascular diseases. Research on mechanism disease is likely to be hampered by sample accessibility, ethical issues, differences between cellular animal physiological studies. However, advances stem cell culture have made it possible reproduce 3D human tissues vitro that mimic cellular, anatomical functional characteristics real organs. Recent studies shown organoids used simulate development gut wide range applications physiology disease. Intestinal provide preeminent model for cultivating microbiota influence GI physiology, well understanding how they encounter epithelial cells mechanistic details obtained from modelling may new avenues prevention treatment many gastrointestinal (GI) disorders. Researchers are now starting take inspiration other fields, bioengineering, rise interdisciplinary approaches, including organoid chip technology microfluidics, greatly accelerated generate more physiologically relevant suitable Here, we describe models biology application study pathophysiology caused dysbiosis.

Language: Английский

Citations

0
Malic enzyme 3 mediated the effects of malic acid on intestinal redox status and feed efficiency in broilers DOI Creative Commons
Hongfeng Jiang,

Genghui Li,

Xue Yang

et al.

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 24, 2025

Abstract Background Intestinal oxidative stress serves as an endogenous host defense against the gut microbiota by increasing energy expenditure and therefore decreasing feed efficiency (FE). Several systems coordinately regulate redox balance, including mitochondrial respiratory chain, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, different antioxidants. However, it remains unclear which balance compartments in intestine are crucial for determining FE. Results In this study, we first screened key targets of metabolites balance-related gene expression broiler ceca. We then constructed a mouse colitis model to explore malic acid (MA) ability alleviate intestinal inflammation. further used controlled release technology coat MA investigated its effects on status FE vivo. Finally, examined underlying mechanism modulated using porcine epithelial cell jejunum 2 (IPEC-J2) vitro. Our results demonstrated that MA/malic enzyme 3 ( ME3 ) pathway may play important role reducing cecum. addition, colon infusion attenuated inflammatory phenotypes dextran sulfate sodium salt (DSS) induced model. Then, dietary supplementation with controlled-release pellet (MAP) reduced gain (F/G) ratio promoted chicken growth, increased bacterial diversity. vitro IPEC-J2 revealed mediated effect cellular stress. Conclusion summary, our study firstly MA/ system hindgut chickens improving health FE, also be implications inflammation associated diseases.

Language: Английский

Citations

0
Static magnetic fields alleviate diabetic nephropathy by reducing renal cell inflammation and promoting M2 macrophage polarization DOI
Weili Chen, Ying Wang, Wenjing Xie

et al.

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(5)

Published: Feb. 27, 2025

Abstract Diabetic nephropathy (DN) is one of the most severe diabetic complications, which can easily progress into irreversible and detrimental end‐stage renal disease if not properly controlled. However, effective prevention DN progression has always remained a huge challenge. Moderate intensity static magnetic fields (SMFs), have advantages non‐invasive high penetration, shown beneficial effects in reducing blood glucose type 2 diabetes mice recent years. In this study, by using both db/db high‐fat diet streptozotocin‐induced moderate mice, we found that SMFs significant on compared to control. Further analyzing with diabetes, kidney inflammation, vascular abnormalities, fibrosis were all greatly reduced. Moreover, promote macrophages polarized M2. vitro cellular experiments also demonstrate positive cell as well increasing M2 macrophage polarization promoting F‐actin assembly. Therefore, our results show great potential be developed new physical modality used treatment DN, possibly other types chronic diseases.

Language: Английский

Citations

0