Microglia specific Csf1r haploinsufficiency induces depressive-like behaviors by promoting NLRP6/caspase-1 signaling in mice DOI
Ran Pang, Jiayi Zheng, Haoyou Xu

et al.

Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Anxiety Disorders: Treatments, Models, and Circuitry Mechanisms DOI Creative Commons
Li Ren,

Yue Fan,

Wenjian Wu

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 983, P. 176994 - 176994

Published: Sept. 12, 2024

Language: Английский

Citations

5
Pde4b-regulated cAMP signaling pathway in the AUDGABA-S1TrSst circuit underlies acute-stress-induced anxiety-like behavior DOI Creative Commons

Zhixin Xiao,

Xiaoya Wang,

Nan Zhou

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(2), P. 115253 - 115253

Published: Jan. 30, 2025

Language: Английский

Citations

0
Dual and plasticity-dependent regulation of cerebello-zona incerta circuits on anxiety-like behaviors DOI Creative Commons

Yue Zhao,

Jintao Wu, Jiabin Feng

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 8, 2025

Clinical observation has identified cerebellar cognitive affective syndrome, which is characterized by various non-motor dysfunctions such as social disorders and anxiety. Increasing evidence revealed reciprocal mono-/poly-synaptic connections of cerebello-cerebral circuits, forming the concept connectome. In this study, we demonstrate that neurons in nuclei (CN) male mice project to a subset zona incerta (ZI) through long-range glutamatergic GABAergic transmissions, both capable encoding acute stress. Furthermore, activating or inhibiting transmissions CN → ZI pathway can positively negatively regulate anxiety place preference presynaptic plasticity-dependent mechanisms, well mediate motor-induced alleviation Our data support close relationship between cerebellum emotional processes suggest targeting outputs may be an effective approach for treating

Language: Английский

Citations

0
Role of glial cells in neurotoxicological effects of alcohol DOI
Yousef Tizabi, Bruk Getachew, Michael Aschner

et al.

Advances in neurotoxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Stress-induced anxiety-related behavior in mice is driven by enhanced excitability of ventral tegmental area GABA neurons DOI Creative Commons

Eric H. Mitten,

Anna Souders,

Ezequiel Marrón Fernández de Velasco

et al.

Frontiers in Behavioral Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: July 17, 2024

Introduction Stress and trauma are significant risk factors for many neuropsychiatric disorders diseases, including anxiety disorders. Stress-induced symptoms have been attributed to enhanced excitability in circuits controlling fear, anxiety, aversion. A growing body of evidence has implicated GABAergic neurons the ventral tegmental area (VTA) aversion processing affective behavior. Methods We used an unpredictable footshock (uFS) model, together with electrophysiological behavioral approaches, investigate role VTA GABA anxiety-related behavior mice. Results One day after a single uFS session, C57BL/6J mice exhibited elevated neuron excitability. The was correlated increased glutamatergic input reduction postsynaptic signaling mediated via B receptors. Chemogenetic activation sufficient increase stress-naïve In addition, chemogenetic inhibition suppressed exposed uFS. Discussion These data show that early substrate stress-induced suggest approaches mitigating may hold promise treatment provoked by stress trauma.

Language: Английский

Citations

4
Cpeb1 remodels cell type–specific translational program to promote fear extinction DOI Creative Commons

Juan Zhang,

Chunqing Yang,

Zhiqiang Liu

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(2)

Published: Jan. 10, 2025

Protein translation is crucial for fear extinction, a process vital adaptive behavior and mental health, yet the underlying cell-specific mechanisms remain elusive. Using Tet-On 3G genetic approach, we achieved precise temporal control over protein in infralimbic medial prefrontal cortex ( IL ) during extinction. In addition, our results reveal that disruption of cytoplasmic polyadenylation element binding 1 (Cpeb1) leads to notable alterations cell type–specific translational programs, thereby affecting Specifically, Cpeb1 deficiency neurons activates heterochromatin 3, which enhances microRNA networks, whereas microglia, it suppresses chemokine receptor Cx3cr1 ), resulting an aged-like microglial phenotype. These coordinated impair spine formation plasticity. Our study highlights critical role extinction provides insight into therapeutic targets disorders with deficits.

Language: Английский

Citations

0
Microglia regulate nucleus accumbens synaptic development and circuit function underlying threat avoidance behaviors DOI Creative Commons
Michael W. Gongwer, Fanny Etienne,

Eric N. Moca

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Abstract While CNS microglia have well-established roles in synapse pruning during neurodevelopment, only a few studies identified for formation. These focused on the cortex and primary sensory circuits restricted developmental time periods, leaving substantial gaps our understanding of early functions microglia. Here we investigated how absence impacts synaptic development nucleus accumbens (NAc), region critical emotional regulation motivated behaviors where dysfunction is implicated psychiatric disorders that arise life. Using genetically modified mouse lacks ( Csf1r ΔFIRE/ΔFIRE ), found blunted excitatory formation NAc. This effect was most prominent second third postnatal weeks, when previously to be overproduced, accompanied by an increase presynaptic release probability alterations postsynaptic kinetics. Tissue-level NAc proteomics confirmed microglial impacted numerous proteins involved structure, trans-synaptic signaling, pre-synaptic function. However, did not perturb levels astrocyte-derived cues adhesive promote synaptogenesis, suggesting reduced number may caused microglial-derived synaptogenic cue. Although observed electrophysiological changes were largely normalized adulthood, lasting effects threat avoidance behavior, these behavioral directly associated with neuronal activity. Together, results indicate role regulating landscape developing establishing functional underlying adult repertoires.

Language: Английский

Citations

0
Anxiolytic effects of accelerated continuous theta burst stimulation on mice exposed to chronic restraint stress and the underlying mechanism involving gut microbiota DOI
Yihan Wang,

Cong Guo,

Berlin Zang

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 375, P. 49 - 63

Published: Jan. 21, 2025

Language: Английский

Citations

0
Pituitary adenylyl cyclase-activating polypeptide modulates the stress response: the involvement of different brain areas and microglia DOI Creative Commons

Aayushee Singh,

Paul Shim,

Sadaf Naeem

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 27, 2025

Stress is necessary for survival. However, chronic unnecessary stress exposure leads to cardiovascular, gastrointestinal and neuropsychiatric disorders. Thus, understanding the mechanisms involved in initiation maintenance of response essential since it may reveal underpinning pathophysiology these disorders aid development medication treat stress-mediated diseases. Pituitary adenylyl cyclase activating polypeptide (PACAP) its receptors (PAC1, VPAC1 VPAC2) are expressed hypothalamus other brain areas as well adrenal gland. Previous research has shown that this peptide/receptor system serves a modulator response. In addition modulating response, also be connected emerging role neuroprotective against hypoxia, ischemia, neurodegeneration. This article aims review literature regarding PACAP involvement different regions microglia PACAP-mediated modulation long-term adaptation recognizable clinically survival with resilience while manifested anxiety, depression neurobehavioral

Language: Английский

Citations

0
Role of Glial Cells and Receptors in Schizophrenia Pathogenesis DOI
Yousef Tizabi, Marta C. Antonelli,

Daniela Tizabi

et al.

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)

Published: Jan. 27, 2025

Language: Английский

Citations

0