Journal of Neuroimaging,
Journal Year:
2024,
Volume and Issue:
34(6), P. 664 - 672
Published: Oct. 27, 2024
Abstract
Background
and
Purpose
Carotid
artery
stenosis
is
a
major
risk
factor
for
ischemic
stroke.
Despite
carotid
stenting,
in‐stent
restenosis
(ISR)
remains
challenging.
Pigs
serve
as
an
ideal
ISR
model.
This
study
aims
to
establish
novel
porcine
model
of
using
open‐loop
closed‐loop
stents
assess
with
optical
coherence
tomography
(OCT)
histopathology,
comparing
incidence
vascular
response
between
stent
types.
Methods
Twelve
adult
male
Bama
miniature
pigs
underwent
stenting
either
or
stents.
The
animals
received
antiplatelet
therapy
pre‐
postimplantation.
Postimplantation
evaluations
at
90
days
included
digital
subtraction
angiography
(DSA),
OCT,
histopathological
examination,
electron
microscopy.
Results
Both
types
showed
detected
by
OCT
DSA.
revealed
comparable
neointimal
proliferation
within
struts
both
types,
no
significant
differences
in
stent,
lumen,
dimensions.
Histopathological
analysis
microscopy
provided
insights
into
tissue
responses
healing
processes
following
implantation.
No
difference
was
found
the
based
on
χ
2
test
(
p
=
.110).
hematoxylin‐eosin
staining
exhibit
highest
consistency
evaluating
area.
Conclusions
demonstrated
similar
outcomes
proved
be
highly
consistent
valuable
tool
arterial
conditions,
findings.
However,
due
small
sample
size,
validity
these
preliminary
findings
requires
further
investigation
confirmed.
ACS Sensors,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 1, 2025
Noncommunicable
diseases
(NCDs)
associated
with
cardiovascular,
neurological,
and
gastrointestinal
disorders
remain
a
leading
cause
of
global
mortality,
sounding
the
alarm
for
urgent
need
better
diagnostic
therapeutic
solutions.
Wearable
implantable
biointegrated
electronics
offer
groundbreaking
solution,
combining
real-time,
high-resolution
monitoring
innovative
treatment
capabilities
tailored
to
specific
organ
functions.
In
this
comprehensive
review,
we
focus
on
affecting
brain,
heart,
organs,
bladder,
adrenal
gland,
along
their
physiological
parameters.
Additionally,
provide
an
overview
characteristics
these
parameters
explore
potential
bioelectronic
devices
in
situ
sensing
applications
highlight
recent
advancements
deployment
across
organs.
Finally,
analyze
current
challenges
prospects
implementing
closed-loop
feedback
control
systems
integrated
sensor-therapy
applications.
By
emphasizing
organ-specific
advocating
systems,
review
highlights
future
bioelectronics
address
needs
serves
as
guide
researchers
navigating
interdisciplinary
fields
diagnostics,
therapeutics,
personalized
medicine.
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
6(1)
Published: June 1, 2024
Abstract
The
objective
of
regenerative
wound
healing
dressings
is
to
accelerate
skin
tissue
regeneration
and
restore
normal
physiological
function
at
sites.
Achieving
this
goal
requires
biomaterials
capable
repairing
distinct
phases
in
a
way
that
balances
material
function,
degradation,
safety,
growth.
In
study,
we
introduced
novel
dual-stage
dressing
system
comprising
methacrylic
anhydride-modified
recombinant
humanized
type
III
collagen
(rhCol
III-MA)
dopamine
(DMA)
(RMDM),
which
was
synthesized
through
free
radical
polymerization
π-π
stacking.
Within
system,
RMDM
formulated
into
two
forms
with
identical
compositions:
hydrogel
sponge,
tailored
for
application
across
various
stages
repair.
These
materials
displayed
favorable
hemocompatibility,
biocompatibility,
antioxidant
properties,
angiogenic
potential
vitro
.
Moreover,
the
vivo
experiments
also
demonstrated
sponges
could
rapidly
stop
bleeding
wounds
mouse
tail
amputation
liver
incision
models.
Notably,
sponge/gel
(S/G)
accelerated
compared
individual
sponge
gel
treatments
rat
full-thickness
model,
underscoring
synergistic
benefits
combining
repair
different
stages.
Therefore,
research
provides
valuable
insights
designing
advanced
can
be
specific
healing,
may
have
significant
biomedical
applications.
Graphical
Small Methods,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 25, 2024
Abstract
Myocardial
infarction
(MI)
has
emerged
as
the
predominant
cause
of
cardiovascular
morbidity
globally.
The
pathogenesis
MI
unfolds
a
progressive
process
encompassing
three
pivotal
phases:
inflammation,
proliferation,
and
remodeling.
Smart
stimulus‐responsive
hydrogels
have
garnered
considerable
attention
for
their
capacity
to
deliver
therapeutic
drugs
precisely
controllably
at
site.
Here,
smart
hydrogel
with
dual‐crosslinked
network
structure
is
designed,
which
enables
precise
controlled
release
in
different
pathological
stages
treatment
MI.
can
rapidly
curcumin
(Cur)
inflammatory
phase
exert
anti‐apoptotic/anti‐inflammatory
effects.
Recombinant
humanized
collagen
type
III
(rhCol
III)
loaded
released
swelled/degraded
during
proliferative
promote
neovascularization.
RepSox
(a
selective
TGF‐β
inhibitor)
releases
from
Pluronic
F‐127
grafted
aldehyde
nanoparticles
(PF127‐CHO@RepSox
NPs)
remodeling
against
fibrosis.
results
vitro
vivo
suggest
that
improves
cardiac
function
alleviates
by
suppressing
inflammation
apoptosis,
promoting
neovascularization,
inhibiting
myocardial
A
whole‐course‐repair
system,
leveraging
multifunctional
hydrogels,
demonstrates
notable
effectiveness
enhancing
post‐MI
facilitating
restoration
damaged
tissue.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(38), P. 50305 - 50320
Published: Sept. 10, 2024
Excessive
fibrotic
scar
formation
during
skin
defect
repair
poses
a
formidable
challenge,
impeding
the
simultaneous
acceleration
of
wound
healing
and
prevention
hindering
restoration
integrity
functionality.
Drawing
inspiration
from
structural,
compositional,
biological
attributes
skin,
we
developed
hydrogel
containing
modified
recombinant
human
collagen
type
III
thiolated
hyaluronic
acid
to
address
challenges
regenerating
appendages
improving
recovery
functions
after
injury
by
reducing
scarring.
The
displayed
favorable
biocompatibility,
antioxidant
properties,
angiogenic
potential,
fibroblast
migration
stimulation
