Risk Factors and Prevention Strategies for Group B Streptococcus Colonization in Pregnant Women and Infection in Newborns

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 25, 2024

Background: Group B Streptococcus (GBS), poses a significant threat to the health of pregnant women and newborns, often leading life-threatening conditions such as neonatal sepsis, meningitis, pneumonia, urinary tract infections. Hence, investigating colonization rate GBS in women, along with associated risk factors their implications on adverse pregnancy outcomes, remains imperative. Objective: This study aims ascertain prevalence late-term analyze influencing infection. Methods: A prospective monitoring was conducted 7751 who underwent screening delivered between January 2020 December 2022. diagnosis via bacterial culture. Results: The found be 6.08% (471/7751), 44 newborns testing positive for (5.68/1000). Among these cases, 27 required hospitalization due EOGBS infection (3.48/1000). Multivariate logistic regression analysis revealed that maternal colonization, premature rupture membranes, chorioamnionitis were independent GBS-positive (P=2.19e-09,P=8.02e-06,P=0.0354). Cesarean section emerged an protective factor against (P=0.0277). Moreover, identified newborns(P=7.41e-07,P=0.00133,P=0.01721). Conclusion: Timely identification enhancing prognosis infants can achieved through intervention newborns.

Language: Английский

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Identification of Glyoxalase A in Group BStreptococcusand its contribution to methylglyoxal tolerance and virulence

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Abstract Group B Streptococcus (GBS) is a Gram-positive pathobiont that commonly colonizes the gastrointestinal and lower female genital tracts but can cause sepsis pneumonia in newborns leading of neonatal meningitis. Despite resulting disease severity, pathogenesis GBS not completely understood, especially during early phases infection. To investigate factors necessary for blood stream survival, we performed transposon (Tn) mutant screen our bacteremia infection model using mariner library previously developed by group. We identified significantly underrepresented mutations 539 genes contribute to survival blood, including those encoding known virulence such as capsule, β-hemolysin, inorganic metal ion transport systems. Most have been characterized or studied GBS, gloA gloB, which are homologs involved methylglyoxal (MG) detoxification. MG byproduct glycolysis highly reactive toxic aldehyde elevated immune cells Here, observed sensitivity across multiple isolates confirm contributes tolerance invasive show specifically presence neutrophils depleting mice abrogates decreased mutant. The requirement glyoxalase pathway suggests detoxification important bacterial host-pathogen interactions. Author Summary A group an murine revealed be β-hemolysin/cytolysin, homeostasis. Many uncharacterized were also part metabolic breaks down (MG). made most cells. common breakdown only two-step process ( ) gloB enzymes. first enzyme pathway, encoded , resistance survival. further demonstrate GloA neutrophil vitro vivo and, therefore, factor required Research aimed at understanding stressors development new treatments will expand knowledge about

Language: Английский

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Intrapartum antibiotic exposure and infectious diseases in childhood – a population-based cohort study

EBioMedicine, Journal Year: 2024, Volume and Issue: 109, P. 105426 - 105426

Published: Nov. 1, 2024

Intrapartum antibiotics are used to prevent group B streptococcus disease in newborn infants. We hypothesised that intrapartum antibiotic exposure is associated with the occurrence of childhood infectious diseases because it influences development gut microbiome.

Language: Английский

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