Genes,
Journal Year:
2024,
Volume and Issue:
15(12), P. 1507 - 1507
Published: Nov. 25, 2024
As
the
global
population
ages,
rising
prevalence
of
neurodegenerative
diseases,
characterized
by
abnormal
protein
aggregates,
presents
significant
challenges
for
early
diagnosis
and
disease
monitoring.
Identifying
accessible
tissue
biomarkers
is
crucial
advancing
our
ability
to
detect
track
progression
these
diseases.
Among
most
promising
skin,
which
shares
a
common
embryological
origin
with
brain
central
nervous
system
(CNS).
This
biological
connection
positions
skin
as
potential
reflection
CNS
pathology.
Over
past
decades,
gene
expression
studies
have
demonstrated
that
key
genes
involved
in
diseases
are
also
expressed
tissues.
Genes
such
Advanced Biology,
Journal Year:
2024,
Volume and Issue:
8(9)
Published: June 27, 2024
Abstract
Population
aging
has
increased
the
global
prevalence
of
aging‐related
diseases,
including
cancer,
sarcopenia,
neurological
disease,
arthritis,
and
heart
disease.
Understanding
aging,
a
fundamental
biological
process,
led
to
breakthroughs
in
several
fields.
Cellular
senescence,
evinced
by
flattened
cell
bodies,
vacuole
formation,
cytoplasmic
granules,
ubiquitously
plays
crucial
roles
tissue
remodeling,
embryogenesis,
wound
repair
as
well
cancer
therapy
aging.
The
lack
universal
biomarkers
for
detecting
quantifying
senescent
cells,
vitro
vivo,
constitutes
major
limitation.
applications
limitations
senescence
biomarkers,
senescence‐associated
β‐galactosidase
staining,
telomere
shortening,
cell‐cycle
arrest,
DNA
methylation,
secreted
phenotypes
are
discussed.
Furthermore,
explore
senotherapeutic
approaches
aging‐associated
diseases
cancer.
In
addition
conventional
this
review
highlighted
vitro,
disease
models
used
studies.
Further,
technologies
from
current
decade
multi‐omics
computational
methods
fields
also
discussed
review.
processes
using
cellular
can
enable
therapeutic
innovation
interventions
improve
quality
life
older
adults.
npj Aging,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: July 10, 2024
Abstract
The
ability
to
reprogram
patient-derived-somatic
cells
IPSCs
(Induced
Pluripotent
Stem
Cells)
has
led
a
better
understanding
of
aging
and
age-related
diseases
like
Parkinson’s,
Alzheimer’s.
established
patient-derived
disease
models
mimic
pathology
can
be
used
design
drugs
for
diseases.
However,
the
age
genetic
mutations
donor
cells,
employed
reprogramming,
differentiation
protocol
might
often
pose
challenges
in
establishing
an
appropriate
model.
In
this
review,
we
will
focus
on
various
strategies
successful
reprogramming
diseases,
emphasizing
accuracy
recapitulation
ways
overcome
limitations
its
potential
application
cell
replacement
therapy
drug
development.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(9), P. 1066 - 1066
Published: Aug. 26, 2024
Skin
aging
is
influenced
by
intrinsic
and
extrinsic
factors
that
progressively
impair
skin
functionality
over
time.
Investigating
the
process
requires
thorough
research
using
innovative
technologies.
This
review
explores
use
of
in
vitro
human
3D
culture
models,
serving
as
valuable
alternatives
to
animal
ones,
research.
The
aim
highlight
benefits
necessity
improving
methodology
analyzing
molecular
mechanisms
underlying
aging.
Traditional
2D
including
monolayers
keratinocytes,
fibroblasts,
or
melanocytes,
even
if
providing
cost-effective
straightforward
methods
study
critical
processes
such
extracellular
matrix
degradation,
pigmentation,
effects
secretome
on
cells,
fail
replicate
complex
tissue
architecture
with
its
intricated
interactions.
Advanced
models
(organoid
cultures,
“skin-on-chip”
technologies,
reconstructed
skin,
bioprinting)
considerably
enhance
physiological
relevance,
enabling
a
more
accurate
representation
peculiar
features.
By
reporting
advantages
limitations
this
highlights
importance
advanced
systems
develop
practical
anti-aging
preventive
reparative
approaches
improve
translational
field.
Further
exploration
these
technologies
will
provide
new
opportunities
for
previously
unexplored
knowledge
Brain Behavior and Immunity,
Journal Year:
2024,
Volume and Issue:
122, P. 216 - 230
Published: Aug. 14, 2024
Pro-inflammatory
cytokines
are
emerging
as
neuroinflammatory
mediators
in
Parkinson's
disease
(PD)
due
to
their
ability
act
through
neuronal
cytokine
receptors.
Critical
questions
persist
regarding
the
role
of
dysfunction
and
contribution
PD
pathology.
Specifically,
potential
synergy
hallmark
protein
alpha-synuclein
(α-syn)
with
is
interest.
We
therefore
investigated
direct
impact
pro-inflammatory
on
neurons
hypothesized
that
α-syn
pathology
exacerbates
cytokine-induced
deficits
PD.
iPSC-derived
cortical
(CNs)
from
healthy
controls
patients
gene
locus
duplication
(SNCA
dupl)
were
stimulated
IL-17A,
TNF-α,
IFN-γ,
or
a
combination
thereof.
For
rescue
experiments,
CNs
pre-treated
anti-oligomerisation
compound
NPT100-18A
prior
IL-17A
stimulation.
Cytokine
receptor
expression,
microtubule
cytoskeleton,
axonal
transport
activity
assessed.
SNCA
dupl
displayed
an
increased
expression
impaired
IL-17A-mediated
regulation.
Cytokines
exacerbated
altered
distribution
tubulin
post-translational
modifications
neurites,
dupl-specific
effects.
Tau
was
also
aggravated
by
mix.
slowed
down
mitochondrial
transport,
retrograde
slowing
only.
The
pre-treatment
prevented
IL-17A-induced
functional
impairments
neural
activity.
Our
work
elucidates
detrimental
effects
cytokines,
particularly
human
structure
function
context
pathology,
suggesting
cytokine-mediated
inflammation
represents
second
hit
which
amenable
modifying
therapies
currently
clinical
trials.
Neuron,
Journal Year:
2025,
Volume and Issue:
113(1), P. 82 - 108
Published: Jan. 1, 2025
SummaryBrain
aging
leads
to
a
decline
in
cognitive
function
and
concomitant
increase
the
susceptibility
neurodegenerative
diseases
such
as
Alzheimer's
Parkinson's
diseases.
A
key
question
is
how
changes
within
individual
cells
of
brain
give
rise
age-related
dysfunction.
Developments
single-cell
"omics"
technologies,
transcriptomics,
have
facilitated
high-dimensional
profiling
cells.
These
technologies
led
new
comprehensive
characterizations
at
resolution.
Here,
we
review
insights
gleaned
from
omics
studies
aging,
starting
with
cell-type-centric
overview
age-associated
followed
by
discussion
cell-cell
interactions
during
aging.
We
highlight
provide
an
unbiased
view
different
rejuvenation
interventions
comment
on
promise
combinatorial
approaches
for
brain.
Finally,
propose
directions,
including
models
neural
stem
focal
point
rejuvenation.
Next frontier.,
Journal Year:
2025,
Volume and Issue:
8(1), P. 219 - 219
Published: Jan. 14, 2025
Aging
is
often
accompanied
by
cognitive
changes,
including
forgetfulness,
which
can
impact
an
individual's
quality
of
life
and
independence.
Recent
advancements
in
Artificial
Intelligence
(AI)
have
opened
avenues
for
addressing
these
challenges
developing
tools
to
support
health
memory.
AI-powered
systems,
such
as
memory
assistance
devices,
predictive
diagnostic
tools,
personalized
training
programs,
offer
transformative
potential
mitigating
the
effects
aging-related
forgetfulness.
This
paper
explores
how
AI
bridge
gaps
traditional
care,
emphasizing
a
human-centered
approach
that
prioritizes
ethical
considerations,
user-friendliness,
inclusivity.
By
analyzing
case
studies
examining
interdisciplinary
methodologies,
research
highlights
both
opportunities
leveraging
enhance
health.
The
findings
underscore
importance
collaboration
between
developers,
healthcare
providers,
end-users
create
solutions
are
effective,
accessible,
empathetic.
integration
into
care
holds
promise
not
only
improving
retention
but
also
fostering
dignity
autonomy
among
aging
populations.
Advanced Biology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 17, 2025
Abstract
Corneal
blindness
remains
a
significant
global
health
challenge,
with
limited
treatment
options
due
to
donor
tissue
scarcity
outside
of
the
United
States
and
inadequate
in
vitro
models.
This
review
analyzes
current
state
cornea
chip
technology,
addressing
fundamental
challenges
exploring
future
directions.
Recent
advancements
biomaterials
fabrication
techniques
are
discussed
that
aim
recapitulate
complex
structure
function
human
cornea,
including
multilayered
epithelium,
organized
stroma,
functional
endothelium.
The
highlights
potential
chips
revolutionize
ocular
research
by
offering
more
predictive
physiologically
relevant
models
for
drug
screening,
disease
modeling,
personalized
medicine.
Current
designs,
their
applications
studying
permeability,
barrier
function,
wound
healing,
limitations
replicating
native
corneal
architecture,
examined.
Key
include
integrating
curvature,
basement
membrane
formation,
innervation.
Applications
explored
modeling
diseases
like
keratitis,
dry
eye
disease,
keratoconus,
Fuchs'
endothelial
dystrophy.
Future
directions
incorporating
curvature
using
hydraulically
controlled
systems,
patient‐derived
cells,
developing
comprehensive
accelerate
therapy
development
reduce
reliance
on
animal
testing.
