Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
30, P. 101394 - 101394
Published: Dec. 9, 2024
Esophageal
cancer
is
the
eighth
most
common
worldwide
and
sixth
leading
cause
of
cancer-related
deaths.
In
this
study,
we
propose
a
novel
esophageal
stent
equipped
with
wireless,
battery-free,
movable
photodynamic
therapy
(PDT)
unit
designed
to
treat
tumors
flexibility,
precision,
real-time
control.
This
system
integrates
PDT
an
electrochemical
pneumatic
soft
actuator
into
conventional
stent.
Each
module
incorporates
piezoelectric
transducer
capable
receiving
external
ultrasound
power
respective
module.
These
transducers
selectively
respond
different
frequencies,
enabling
independent
operation
without
mutual
interference.
The
provides
light
source
for
PDT,
inducing
production
cytotoxic
reactive
oxygen
species
(ROS)
in
tumor
cells
promoting
apoptosis.
based
on
principles
plays
critical
role
controlling
position
source,
movement
up
200
mm
within
15
min.
allows
control
maintain
near
tumor,
ensuring
precise
targeted
treatment.
can
wirelessly
source's
via
ultrasound,
offering
approach
treating
patients
according
need
tumor's
progression.
Sensors,
Journal Year:
2024,
Volume and Issue:
24(9), P. 2714 - 2714
Published: April 24, 2024
In
this
paper,
we
present
a
novel
three-dimensional
(3D)
coupled
configuration
of
piezoelectric
micromachined
ultrasound
transducers
(pMUTs)
by
combing
curved
and
an
annular
diaphragm
for
transmit
performance
optimization
in
biomedical
applications.
An
analytical
equivalent
circuit
model
(EQC)
is
developed
with
varied
excitation
methods
to
incorporate
the
acoustic–structure
coupling
diaphragm-coupled
pMUTs
(CAC-pMUTs).
The
model-derived
results
align
well
reference
simulated
finite
element
method
(FEM).
Using
EQC
model,
optimize
key
design
parameters
CAC-pMUTs
order
improve
output
sound
pressure,
including
width
membrane,
thickness
passive
layer,
phase
difference
driving
voltage.
anti-phase
mode,
designed
demonstrate
efficiency
285
times
higher
than
that
single
pMUTs.
This
substantial
improvement
underscores
potential
large
array
Russian Ophthalmological Journal,
Journal Year:
2024,
Volume and Issue:
17(2), P. 128 - 134
Published: July 2, 2024
The
review
presents
recent
research
works
on
new
technologies
of
scleral
collagen
crosslinking,
a
promising
approach
to
sclerastrengthening
treatment
progressive
myopia.
We
assess
the
advantages
and
limitations
number
experimental
techniques
photochemical
medicinal
crosslinking
sclera,
as
well
donor
tissue
aimed
at
optimizing
plastic
material
for
sclera-strengthening
surgery.
Successful
experiments
effective
first
clinical
implementation
results
can
be
viewed
basis
its
further
improvement
wider
introduction
technology
into
ophthalmological
practice.
MedComm – Biomaterials and Applications,
Journal Year:
2024,
Volume and Issue:
3(3)
Published: July 29, 2024
In
a
recent
paper
published
in
Nature
Communications,
Zhong
et
al.1
described
wireless
battery-free
ocular
modulation
patch.
This
patch
could
be
utilized
posterior
scleral
reinforcement
(PSR)
surgery,
to
correct
high
myopia
by
shortening
the
axial
length
(AXL)
and
reinforce
sclera
prevent
recurrence.
Myopia
is
state
of
refraction
which
parallel
rays
light
coming
from
infinity
are
brought
focus
front
retina.
The
mechanism
involves
various
signals
traveling
retina
through
choroid
sclera,
eventually
resulting
weakening
AXL
elongation.
elongation
occurs,
causing
fail
converge
on
also
leads
complications
arising
changes
segment
structures
eye,
including
staphyloma
myopic
maculopathy,
turn,
contributes
continual
expansion
globe
direction.
There
many
surgical
options
available
for
patients
with
myopia.
Myopic
avoid
wearing
glasses
corneal
laser
surgery
Implantable
Collamer
Lens
work
flattening
cornea
or
adding
lenses
anterior
chamber
help
However,
these
surgeries
purely
optical
corrections
do
not
address
pathological
structure
eyeballs.
Comparatively,
traditional
PSR
aims
strengthen
weakened
technique
was
first
reported
Shevelev
1930
later
modified
Snyder
Thompson.
primary
goal
shorten
achieve
perfect
convergence
Thus,
particularly
essential
related
complications.
research
background,
al.
proposed
concept,
that
novel
remarkably
groundbreaking,
potentially
allowing
precise
personalized
treatment
PSR.
Furthermore,
macular
buckle
primarily
used
treat
schisis
myopia,
addressing
traction
caused
area
promoting
reattachment
schisis.
this
focused
more
specifically
shrinkage
further
reinforcing
cross-linking
(SCXL).
For
decades,
have
consisted
homologous
dura
mater
pericardium
patches.2
years,
nonbiological
source
materials
gained
popularity.
Researchers
using
hydrogel
were
PSR,
but
studies
remained
limited
animal
experiments.3,
4
developed
patch,
powered
controlled
an
external
ultrasound
source.
piezoelectric
transducers,
electrochemical
micro-actuator,
drug
microneedle
array,
μ-LEDs,
flexible
circuit
biocompatible
encapsulation
(Figure
1).
adoption
energy
transmission
eliminated
inaccuracies
associated
controlling
mitigates
potential
hazards
posed
cumbersome
batteries.
wirelessly
powering
micro-actuator
trigger
electrolysis
process,
involved
use
microfabricated
copper/gold-forked
electrodes
electrolyze
aqueous
solution,
producing
hydrogen
oxygen
gas.
generation
gas
led
mechanical
deformation
polydimethylsiloxane/polystyrene-block-polybutadiene-block-polystyrene
membrane.
When
placed
rabbit
eye
globe,
applied
pressure
macula,
thus
inducing
action.
After
activated,
underwent
reduction
approximately
1217
μm.
human
eyes,
μm
change
translated
modification
refractive
power
2.5D
patients.
study,
solely
observed
impact
normal
rabbits.
We
eagerly
await
assessment
efficacy
like
addition,
control
coupled
another
function:
SCXL.
integration
SCXL
theoretically
stabilized
shortened
AXL,
prolonging
effectiveness
aiding
reducing
recurrence
Previously,
development
lagged
far
behind
cross-linking,
only
being
investigated
experiments.
due
anatomical
location
made
effective
delivery
photosensitizers
illumination
challenging.
Most
articles
describe
360-degree
conjunctival
peritomy
muscle
expose
equatorial-posterior
sclera.
Riboflavin
then
exposed
area,5
some
mentioning
iontophoresis
technology
enhance
absorption.
Since
it
difficult
most
targeted
equatorial
region
position
combined
SXL
directly
target
Notably,
marked
instance
delivering
riboflavin
array
(polyvinylpyrrolidone
riboflavin),
overcoming
previous
challenges
commonly
blue
side
effects
ultraviolet
light.
μ-LED
(443
nm)
has
already
been
activated
ultrasound.
combination
within
single
procedure
represented
exceptionally
innovative
concept.
emergence
significantly
advance
application
composite
control.
Measurements
rigidity
revealed
that,
increased
Young's
modulus
151.25%
at
Day
7
387%
22.
Collagen
fibers
exhibited
tightly
arranged
after
Analysis
porosity
H&E-stained
sections
showed
58.33%
decrease
group
compared
group.
A
comparison
therapeutic
varying
intensities
exposure
different
concentrations
might
future
As
Zhang
noted,
study
had
limitations
its
small
sample
size
relatively
short
22-day
postsurgery
observation
period.
Potential
postoperative
complications,
such
as
hypertension,
tissue
edema,
vitreous
hemorrhage,
should
considered
future.
would
interesting
consider
choroidal
thickness
blood
flow
postsurgery,
found
closely
summary,
treating
functions
manner.
While
there
methods
achieving
balance
between
safety
often
crucial.
article
introduced
concept
issues
unresolved.
Further
needed
long-term
monitoring
safety.
eyes
differs
so
uncertain
whether
needs
redesigned
use.
Additionally,
we
anticipate
seeing
new
considering
significant
differences
Lin
Ye:
Conceptualization;
investigation;
visualization;
writing—original
draft.
Jing
Zheng:
project
administration;
supervision;
writing—review
&
editing.
All
authors
read
approved
final
manuscript.
supported
Grant
24NSFSC8140
Sichuan
Natural
Science
Foundation
Young
Scholars.
declare
no
conflict
interest.
Not
applicable.
Data
sharing
applicable
data
created
analyzed
study.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
30, P. 101394 - 101394
Published: Dec. 9, 2024
Esophageal
cancer
is
the
eighth
most
common
worldwide
and
sixth
leading
cause
of
cancer-related
deaths.
In
this
study,
we
propose
a
novel
esophageal
stent
equipped
with
wireless,
battery-free,
movable
photodynamic
therapy
(PDT)
unit
designed
to
treat
tumors
flexibility,
precision,
real-time
control.
This
system
integrates
PDT
an
electrochemical
pneumatic
soft
actuator
into
conventional
stent.
Each
module
incorporates
piezoelectric
transducer
capable
receiving
external
ultrasound
power
respective
module.
These
transducers
selectively
respond
different
frequencies,
enabling
independent
operation
without
mutual
interference.
The
provides
light
source
for
PDT,
inducing
production
cytotoxic
reactive
oxygen
species
(ROS)
in
tumor
cells
promoting
apoptosis.
based
on
principles
plays
critical
role
controlling
position
source,
movement
up
200
mm
within
15
min.
allows
control
maintain
near
tumor,
ensuring
precise
targeted
treatment.
can
wirelessly
source's
via
ultrasound,
offering
approach
treating
patients
according
need
tumor's
progression.
