Epigenetics of Hypertensive Nephropathy DOI Creative Commons

Yize Zhang,

Hamidreza Arzaghi,

Zhehan Ma

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2622 - 2622

Published: Nov. 16, 2024

Hypertensive nephropathy (HN) is a leading cause of chronic kidney disease (CKD) and end-stage renal (ESRD), contributing to significant morbidity, mortality, rising healthcare costs. In this review article, we explore the role epigenetic mechanisms in HN progression their potential therapeutic implications. We begin by examining key modifications-DNA methylation, histone modifications, non-coding RNAs-observed disease. Next, discuss underlying pathophysiology highlight current vitro vivo models used study condition. Finally, compare various types HN-induced injury associated with those observed other models, drawing inferences on therapies for HN. The information gathered work indicate that can drive regulating molecular signaling pathways involved damage fibrosis. limitations Renin-Angiotensin-Aldosterone System (RAAS) inhibitors underscore need alternative treatments targeting pathways. This emphasizes importance further research into regulation develop more effective preventive strategies. Identifying novel markers could provide new opportunities managing CKD reducing burden ESRD.

Language: Английский

Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants DOI
Hongbo Liu, Amin Abedini, Eunji Ha

et al.

Science, Journal Year: 2025, Volume and Issue: 387(6734)

Published: Feb. 6, 2025

Kidney dysfunction is a major cause of mortality, but its genetic architecture remains elusive. In this study, we conducted multiancestry genome-wide association study in 2.2 million individuals and identified 1026 (97 previously unknown) independent loci. Ancestry-specific analysis indicated an attenuation newly signals on common variants European ancestry populations the power population diversity for further discoveries. We defined genotype effects allele-specific gene expression regulatory circuitries more than 700 human kidneys 237,000 cells. found 1363 coding disrupting 782 genes, with 601 genes also targeted by convergence 161 genes. Integrating 32 types information, present “Kidney Disease Genetic Scorecard” prioritizing potentially causal cell types, druggable targets kidney disease.

Language: Английский

Citations

2
Genetic Insights into Blood Pressure From Kidney Multi-Omics DOI
Chenyu Li, Katalin Suszták

American Journal of Kidney Diseases, Journal Year: 2024, Volume and Issue: 84(6), P. 787 - 790

Published: July 9, 2024

Language: Английский

Citations

1
Exploring novel therapeutic opportunities for hypertension: a paradigm-shifting approach via integrative multiomic analysis, pioneering the path to precision medicine DOI

Sushant Saluja,

Rachel Lennon

Journal of Hypertension, Journal Year: 2024, Volume and Issue: 42(7), P. 1147 - 1149

Published: May 30, 2024

aDivision of Cardiovascular Sciences, Faculty Biology, Medicine and Health, The University Manchester bDivision Academic Health Science Centre, NHS Foundation Trust cWellcome Centre for Cell-Matrix Research, Division Biology Regenerative Medicine, School Biological Manchester, UK Correspondence to Sushant Saluja, Medicine: United Kingdom. E-mail: [email protected]

Language: Английский

Citations

0
scTWAS Atlas: an integrative knowledgebase of single-cell transcriptome-wide association studies DOI Creative Commons
Jialin Mai, Qiheng Qian, Hao Gao

et al.

Nucleic Acids Research, Journal Year: 2024, Volume and Issue: 53(D1), P. D1195 - D1204

Published: Oct. 18, 2024

Single-cell transcriptome-wide association studies (scTWAS) is a new method for conducting TWAS analysis at the cellular level to identify gene-trait associations with higher precision. This approach helps overcome challenge of interpreting cell-type heterogeneity in traditional results. As field scTWAS rapidly advances, there growing need additional database platforms integrate this wealth data and knowledge effectively. To address gap, we present Atlas (https://ngdc.cncb.ac.cn/sctwas/), comprehensive information integrating literature curation analysis. The current version amasses 2,765,211 encompassing 34 traits, 30 cell types, 9 conditions 16,470 genes. features visualization tools, including an interactive graph that integrates single-cell expression quantitative trait loci (sc-eQTL) build multi-omics regulatory network level. Additionally, facilitates cross-cell-type analysis, highlighting cell-type-specific shared designed user-friendly interfaces allows easy browsing, searching, downloading relevant information. Overall, instrumental exploring genetic mechanisms shedding light on role various types biological processes, offering novel insights human health research.

Language: Английский

Citations

0
Omics Studies in CKD: Diagnostic Opportunities and Therapeutic Potential DOI
Merita Rroji, Goce Spasovski

PROTEOMICS, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Omics technologies have significantly advanced the prediction and therapeutic approaches for chronic kidney disease (CKD) by providing comprehensive molecular insights. This is a review of current state future prospects integrating biomarkers into clinical practice CKD, aiming to improve patient outcomes targeted interventions. In fact, integration genomic, transcriptomic, proteomic, metabolomic data has enhanced our understanding CKD pathogenesis identified novel an early diagnosis treatment. Advanced computational methods artificial intelligence (AI) further refined multi-omics analysis, leading more accurate models progression responses. These developments highlight potential care with precise individualized treatment plan .

Language: Английский

Citations

0
Epigenetics of Hypertensive Nephropathy DOI Creative Commons

Yize Zhang,

Hamidreza Arzaghi,

Zhehan Ma

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2622 - 2622

Published: Nov. 16, 2024

Hypertensive nephropathy (HN) is a leading cause of chronic kidney disease (CKD) and end-stage renal (ESRD), contributing to significant morbidity, mortality, rising healthcare costs. In this review article, we explore the role epigenetic mechanisms in HN progression their potential therapeutic implications. We begin by examining key modifications-DNA methylation, histone modifications, non-coding RNAs-observed disease. Next, discuss underlying pathophysiology highlight current vitro vivo models used study condition. Finally, compare various types HN-induced injury associated with those observed other models, drawing inferences on therapies for HN. The information gathered work indicate that can drive regulating molecular signaling pathways involved damage fibrosis. limitations Renin-Angiotensin-Aldosterone System (RAAS) inhibitors underscore need alternative treatments targeting pathways. This emphasizes importance further research into regulation develop more effective preventive strategies. Identifying novel markers could provide new opportunities managing CKD reducing burden ESRD.

Language: Английский

Citations

0