Elevated blood remnant cholesterol and triglycerides are causally related to the risks of cardiometabolic multimorbidity

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 19, 2024

Abstract The connection between triglyceride-rich lipoproteins and cardiometabolic multimorbidity, characterized by the concurrence of at least two type 2 diabetes, ischemic heart disease, stroke, has not been definitively established. We aim to examine prospective associations serum remnant cholesterol, triglycerides, risks progression from first disease multimorbidity via multistate modeling in UK Biobank. also evaluate causality these Mendelian randomization using 13 biologically relevant SNPs as genetic instruments. Here we show that elevated cholesterol triglycerides are significantly associated with gradually higher particularly diabetes. These results advocate for effective management a potential strategy mitigating multimorbidity.

Language: Английский

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Analysis of Metabolic Risk Factors for Microcirculation Disorders Post-Percutaneous Coronary Intervention and Predictive Model Construction: A Study on Patients with Unstable Angina

Reviews in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 8, 2025

Background: This study aimed to analyze the metabolic risk factors for microcirculation disorders in patients with unstable angina (UA) after percutaneous coronary intervention (PCI), evaluating their predictive value developing disorders. Methods: A single-center retrospective design was used, which included 553 UA who underwent PCI. The angiographic microcirculatory resistance (AMR) index calculated based on angiography data. Patients were divided into two groups according post-PCI AMR values: a ≤2.50 group and >2.50 group. Variables multivariate regression model through univariate variance inflation factor (VIF) screening. Subgroup analyses conducted by sex further evaluate of selected variables overall sample. total sample randomly split 7:3 ratio training validation sets. nomogram sets then constructed visualize these predictions. discrimination calibration prediction evaluated using receiver operating characteristic (ROC) curve curve. Results: had higher percentage females, increased incidence diabetes, elevated fasting blood glucose (FBG), glycated hemoglobin (HbA1c), triglyceride (TG), cholesterol (TC), low-density lipoprotein (LDL-C), very (VLDL-C), lipoprotein(a) (Lp(a)) levels (p < 0.05). Logistic analysis identified HbA1c, TG, LDL-C, Lp(a) as independent predictors adjusting confounders. confirmed no significant interaction between > set, area under (AUC) ROC 0.824 set 0.746 set. curves showed good fit (training set: p = 0.219; 0.258). Conclusions: are post-PCI. provides accuracy.

Language: Английский

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Drugs for dyslipidaemia: the legacy effect of the Scandinavian Simvastatin Survival Study (4S)

The Lancet, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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Association of pyridoxal 5′-phosphate (PLP) with lipid profiles: a population-based cohort study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 26, 2025

This study aims to explore the correlation between Pyridoxal 5'-Phosphate (PLP) levels and lipid profiles in adult individuals, utilizing data from National Health Nutrition Examination Survey (NHANES) database. The research included individuals aged 20 years above, extracted NHANES database, covering period 2005 2010. primary objective was scrutinize relationship PLP profiles. accomplished by employing weighted, multivariable logistic regression ascertain these associations. Furthermore, assess variability within different demographic segments, interaction analyses were conducted. Additionally, restricted cubic spline (RCS) methodology implemented delve into potential nonlinear dynamics concentrations levels. A cohort of 6,459 this study. Our indicated that 51.60% participants under 50 old, while 48.40% over 50, comprising 48.83% males 51.17% females. demonstrated a negative with low-density lipoprotein cholesterol (LDL-C) After controlling for confounding variables, one-unit increment correlates reduction 17.7% LDL-C (OR: 0.823, 95% CI: 0.823-0.824, p < 0.001). exhibited positive high-density (HDL-C), which increased as rose. all covariates, increase corresponded 1.952-fold enhancement probability high HDL-C 1.952, 1.951-1.953, nonlinear. Subgroup are positively correlated, especially among diabetic patients non-drinkers. inversely associated HDL-C, stronger effects observed These findings underscore clinical utility supplementation preventive measure against cardiovascular metabolic diseases.

Language: Английский

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Joint assessment of abdominal obesity and non-traditional lipid parameters for primary prevention of cardiometabolic multimorbidity: insights from the China health and retirement longitudinal study 2011–2018

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 8, 2025

Obesity and abnormal lipid metabolism increase the risk of various cardiometabolic diseases, including diabetes, heart disease, stroke. However, impact abdominal obesity (AO) non-traditional parameters on multimorbidity (CMM) remains unclear. This study aims to investigate separate combined effects AO incidence CMM. enrolled 7,597 eligible participants from China health retirement longitudinal (CHARLS). Cox proportional hazards models were used perform adjusted regression analyses mediation analyses, with Kaplan-Meier analysis for cumulative hazards. Restricted cubic splines utilized evaluate nonlinear relationship between CMM among AO. Subgroup conducted stratification by age, gender, BMI, smoking status, drinking hypertension interaction across different populations. Additionally, sensitivity further performed subgroups During 7-year follow-up period, a total 699 (9.20%) newly diagnosed curves revealed that subgroup both high levels had highest hazard developing In fully model, exhibited confirmed robustness these findings, showing consistent results demographic groups under analytical conditions. Furthermore, was found significantly mediated associations The associated Notably, may induce partially mediating serum lipids in human metabolism. findings highlighted importance joint evaluation primary prevention

Language: Английский

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The relationship between remnant cholesterol and young-onset myocardial infarction in patients with type 2 diabetes: a retrospective study

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 17, 2025

Remnant cholesterol (RC) has emerged as a novel therapeutic target beyond low-destiny-lipoproteins (LDL-c). While elevated RC levels are strongly associated with cardiovascular disease risk in the general population, their specific role young-onset acute myocardial infarction (AMI) among patients type 2 diabetes mellitus (T2DM) remains insufficiently explored and warrants further investigation. This retrospective study included AMI T2DM admitted to First Affiliated Hospital of Xi'an Jiaotong University from 2018 2022. Patients were stratified into tertiles according compared using thresholds derived commanded values PREDIMED cohort study. The primary outcome was AMI. Group differences analyzed chi-square test Kruskal-Wallis H test, while Spearman correlation analyses assessed relationships between variables. Univariate multivariate logistic regression employed evaluate association Among 2,514 participants (mean age 61.58 ± 11.15 years), 802 (31.9%) had increase increased significantly rising (27.0% vs 29.7% 39.1%, P < 0.001). showed significant positive total (TC, r = 0.497, 0.001), triglycerides (TG, 0.411, LDL-c (r 0.166, independently higher (OR: 1.579; 95% CI: 1.354-1.842; even after adjusting for other traditional factors 1.415; CI 1.189-1.684; Notably, remained linked regardless whether within desired range. is independent factor patients, irrespective level. These findings underscore importance monitoring managing clinical practice mitigate this population.

Language: Английский

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Effects of remnant cholesterol on adverse renal outcomes in lupus nephritis

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 10, 2025

Remnant cholesterol (RC) causes inflammation and promotes kidney diseases development. However, its role in lupus nephritis (LN) remains unclear. The purpose of this study was to investigate the association between RC LN. This observational conducted among patients enrolled 2000 2018 High Quality Evidence Guangzhou Lupus Nephritis Cohort. outcomes were defined as adverse renal outcomes, including serum creatinine doubled end-stage disease. Patients stratified into lower higher groups based on optimal cutoff value (86.88 mg/dL) for outcomes. To explore RC, survival analyses, multivariate Cox regression subgroup analyses conducted. Overall, 909 individuals enrolled. Over a median follow-up 8.33 (interquartile range, 3.08-12.83) years, 134(14.74%) them reached endpoints. Kaplan-Meier indicated that with levels more susceptible LN (P < 0.001). After adjusting confounding factors, exhibited significant correlations [hazard ratio (HR):1.98, 95% confidence interval (CI):1.16-3.39; P = 0.012]. Subgroup revealed strong relationship particularly aged 40 an estimated glomerular filtration rate 60 ml/min/1.73m2 or proliferative pathological changes nephrotic syndrome 0.05). Higher significantly associated poor LN, indicating may become non-invasive prognostic tool clinical assessment

Language: Английский

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Great debate: Plasma triglycerides are an important causal factor and therapeutic target for atherosclerotic cardiovascular disease

European Heart Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

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Transport functions of intestinal lymphatic vessels

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Language: Английский

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Elevated Remnant Cholesterol Predicts Poor Outcome in Patients with Premature Acute Coronary Syndrome：A Retrospective, Single-Center Study

Published: May 7, 2025

Background The association of remnant cholesterol (RC) with recurrent cardiovascular events following acute coronary syndrome (ACS) is well documented. However, no RC-stratified analysis focused on patients premature ACS (PACS). Objectives This study sought to elucidate the clinical characteristics and subsequent in high RC low PACS. Methods In this retrospective cohort study, we consecutively recruited 820 PACS between January 2019 2020. was calculated as total minus high-density lipoprotein low-density cholesterol. ≥ 66.6 percentile defined RC. primary endpoint major adverse cerebrovascular event (MACCE), including death, myocardial infarction (MI), stroke, ischemia-driven revascularization, or hospitalization for unstable angina heart failure. Results Among enrolled, 277 (33.8%) were 543 (66.2%) High had higher prevalence traditional risk factors diabetes (33.6% vs 27.3%, p = 0.04), hypertension (68.2% 61.3%, hyperlipidemia (43.3% 31.3%, 0.001). levels glucose (p < 0.001), hemoglobin A1C 0.005), triglyceride 0.001) LDL-C 0.017) group significantly than those group, while HDL-C lower. During 3 years follow-up, RC, compared have a cumulative incidence MACCE (16.2% 10.9%; adjusted HR 1.68, 95% CI 1.10–2.59; 0.02). increased primarily attributable rates (12.3% 7.9%; 1.69, 1.03–2.75; 0.03) composite cardiac MI, revascularization failure (14.8% 9.8%; 1.75, 1.12–2.73; 0.01). Conclusions hospitalized patients, that during median follow-up nearly years. incremental might be explained by events. Therefore, should pay close attention indicator pursue further exploration.

Language: Английский

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