ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
11(1), P. 429 - 441
Published: Dec. 19, 2024
Chemotherapeutic
drugs
often
fail
to
localize
efficiently
tumors
when
administered
intravenously,
causing
off-target
effects.
This
study
proposes
an
autologous
erythrocyte
(ER)-anchoring
strategy
improve
chemotherapy
efficacy
and
reduce
side
Utilizing
a
modified
hemodialysis
instrument,
closed-system
drug-transfer
device
was
developed
for
ER
procurement
immunogenicity
mitigation.
Doxorubicin
(DOX)
indocyanine
green
(ICG)
were
encapsulated
in
ERs
then
with
DSPE-PEG-FA.
The
final
product,
DOX-ICG@ER-D,
reintroduced
into
circulation
enhance
chemotherapy.
These
obtained
DOX-ICG@ER-D
showed
good
stability,
minimal
cardiotoxicity,
extended
time.
Compared
free
DOX,
had
higher
accumulation
of
DOX
hepatocellular
carcinoma
the
release
could
be
controlled
by
laser
irradiation.
Tumor-bearing
rats
treated
these
demonstrated
improved
antitumor
reduced
cardiotoxicity.
Thus,
this
ER-anchoring
offers
promising
alternative
intravenous
clinic.
Biochemical and Biophysical Research Communications,
Journal Year:
2024,
Volume and Issue:
720, P. 150060 - 150060
Published: May 8, 2024
Artificial
Intelligence
(AI)
is
having
a
revolutionary
impact
on
our
societies.
It
helping
humans
in
facing
the
global
challenges
of
this
century.
Traditionally,
AI
developed
software
or
through
neuromorphic
engineering
hardware.
More
recently,
brand-new
strategy
has
been
proposed.
so-called
Chemical
(CAI),
which
exploits
molecular,
supramolecular,
and
systems
chemistry
wetware
to
mimic
human
intelligence.
In
work,
two
promising
approaches
for
boosting
CAI
are
described.
One
regards
designing
implementing
neural
surrogates
that
can
communicate
optical
chemical
signals
give
rise
networks
computational
purposes
develop
micro/nanorobotics.
The
other
approach
concerns
"bottom-up
synthetic
cells"
be
exploited
applications
various
scenarios,
including
future
nano-medicine.
Both
topics
presented
at
basic
level,
mainly
inform
broader
audience
non-specialists,
so
favour
interest
these
frontier
subjects.
Advanced Biology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 31, 2025
Abstract
Synthetic
cells
(SCs),
developed
through
bottom‐up
synthetic
biology,
hold
great
potential
for
biomedical
applications,
with
the
promise
of
replacing
malfunctioning
natural
and
treating
diseases
spatiotemporal
control.
Currently,
most
SC
synthesis
characterization
processes
are
manual,
limiting
scalability
efficiency.
In
this
study,
an
automated
method
is
large‐scale
production
protein‐producing
SCs
therapeutic
applications.
The
optimized
process,
compatible
a
robotic
liquid
handling
system
(LiHa),
reduces
time
by
half.
Additionally,
incorporation
tissue
dissociator‐based
emulsification
increases
batch
size
30‐fold
while
preserving
characteristics.
To
assess
quality
protein
synthesis,
artificial
intelligence
(AI)‐based
image
analysis
employed,
allowing
automated,
accurate
high‐throughput
characterization.
Large‐scale
luciferase‐expressing
from
single
homogeneous
administered
to
mice,
real‐time
monitoring
expression
reducing
experimental
variability.
By
troubleshooting
several
central
steps
in
it
demonstrated
that
automation
computerized
control
can
significantly
improve
process
preclinical
clinical
Precision medicine and engineering.,
Journal Year:
2024,
Volume and Issue:
1(1), P. 100004 - 100004
Published: Aug. 13, 2024
The
vesicle,
which
consists
of
the
cytoplasm
encapsulated
by
lipid
bilayer,
has
acted
as
an
important
mediator
intercellular
communication
a
potential
tool
for
disease
treatment
during
past
decade.
In
addition
to
ability
biological
amphiphiles
form
vesicles,
artificial
vesicles
can
also
be
formed
from
synthetic
polymers,
have
been
widely
applied
in
transport,
temporary
storage
and
chemical
reaction
chambers.
this
review,
we
summarized
progress
use
polymer
nanoreactors
biomedical
applications.
First,
various
preparation
methods,
including
hydration,
polymerization-induced
self-assembly,
solvent
exchange,
emulsion
phase
transfer,
microfluidics
flash
nanoprecipitation,
are
compared
here.
Second,
applications
nanoreactors,
such
stimuli-responsive
drug
delivery,
blood–brain
barrier
penetration,
enhanced
physiological
stability,
diseases,
highlighted
review.
addition,
existing
obstacles
future
development
directions
proposed
broader
clinical
translations.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101565 - 101565
Published: Feb. 8, 2025
Artificial
cells
have
bridged
the
gap
between
non-living
systems
and
biological
cells.
In
recent
years,
artificial
designed
to
simulate
cellular
structure
function
garnered
significant
attention.
These
demonstrate
vast
potential
for
advancements
in
various
biomedical
areas,
including
simulating
cell
function,
creating
innovative
biosensors,
facilitating
bioactives
transport,
enabling
micro
nanoreactors,
improving
targeted
therapy
chronic
foodborne
diseases.
interdisciplinary
field
of
construction,
based
on
their
constituent
components,
these
can
be
categorized
into
lipid/polymer
vesicles,
coacervate,
colloidosome,
metal-organic
framework
(MOF)
They
are
anticipated
significantly
enhance
food
science,
particularly
optimization,
precise
nutrition
delivery,
nutrient
release,
rapid
detection
methods.
Consequently,
this
paper
will
comprehensively
cover
historical
background,
fabrication
techniques,
structural
characteristics
From
a
functional
design
perspective,
review
examines
growth
division
mechanisms,
energy
production
processes,
encapsulation
reaction
vessels,
carriers,
information
exchange
Ultimately,
it
provides
comprehensive
evaluation
safety
from
both
environmental
viewpoints,
introduce
expand
application
scenarios
biotechnology
science.
Therapeutic Delivery,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 9
Published: March 9, 2025
Oxygen
therapeutics
hold
great
potential
as
alternatives
to
red
blood
cell/whole
transfusions.
The
development
of
hemoglobin-based
oxygen
carriers
began
in
the
1930s,
but,
regrettably,
none
have
received
FDA
approval.
This
review
starts
with
an
overview
cell
physiology
and
then
focuses
on
(including
modified
encapsulated
hemoglobin)
well
mimetics,
particularly
regarding
their
size
shape.
also
addresses
different
approaches
carriers.
Macromolecular Bioscience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 25, 2025
Artificial
cells
represent
a
transformative
innovation
in
biomedical
science,
offering
engineered,
cell-like
constructs
capable
of
mimicking
certain
biological
functions.
Although
remarkable
progress
has
been
made
to
construct
complex
multifunctional
artificial
cells,
there
are
still
significant
differences
between
and
natural
cells.
Thus,
thorough
understanding
the
techniques
challenges
associated
with
fabrication
alongside
their
applications,
is
essential
for
driving
further
technological
this
field.
This
review
aims
summarize
recent
advances
preparation
applications
In
emphasize
potential
revolutionize
cancer
therapeutics,
gene
therapy,
immunotherapy,
vaccine,
reactors
manufacture
biomolecules
signal
communication.
primarily
fabricated
through
bottom-up
approaches,
including
liposomes,
metal-organic
frameworks,
colloidal,
hydrogel,
droplet
microfluidic
which
allow
precise
control
over
composition,
structure,
functionality.
Finally,
future
outlook
development
simulating
real
activities
described.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 3, 2025
The
assembly
of
protocells
into
prototissues
represents
a
significant
step
forward
in
mimicking
the
hierarchical
structure
and
complex
functions
biological
tissues.
This
review
explores
construction
various
protocell
models,
including
lipid
vesicles,
polymer
proteinosomes,
membraneless
coacervates,
emulsion
droplets.
It
examines
range
chemical
physical
methods
employed
to
spatially
organize
these
structured,
functional
prototissues.
Furthermore,
highlights
distinctive
properties
prototissues,
such
as
their
ability
facilitate
intra-
inter-protocell
communication,
exhibit
collective
behaviors
like
oscillations
deformation,
promising
applications
biomedicine.
By
bridging
gap
between
synthetic
cells
tissue-like
systems,
this
provides
insights
design,
fabrication,
potential
biology
regenerative
medicine.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
unknown, P. 101723 - 101723
Published: April 1, 2025
Biomimetic
Artificial
Cells
(ACs)
are
engineered
systems
that
mimic
the
properties
and
functions
of
natural
cells,
offering
significant
potential
for
biomedical
applications.
The
performance
applicability
these
synthetic
constructs
depend
on
choice
materials
fabrication
methods.
Our
review
delves
into
materials,
techniques,
diverse
applications
ACs,
emphasizing
their
transformative
impact
field
cancer
therapy
as
smart
vehicles
drug
delivery,
immune
system
stimulation,
cell
targeting
to
minimize
off-target
effects
maximizing
therapeutic
efficacy
well
in
vitro
models
research.
By
providing
a
comprehensive
overview,
we
aim
elucidate
how
cells
can
move
forward,
innovative
solutions
longstanding
challenges
treatment
opening
new
frontiers
less
toxic
options.
