The Chemical Record,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 27, 2024
Carbohydrates
are
natural,
renewable,
chemical
compounds
that
play
crucial
roles
in
biological
systems.
Thus,
efficient
and
stereoselective
glycosylation
is
an
urgent
task
for
the
preparation
of
pure
structurally
well-defined
carbohydrates.
Photoredox
catalysis
has
emerged
as
a
powerful
tool
carbohydrate
chemistry,
providing
alternative
addressing
some
challenges
glycochemistry.
Over
last
few
decades,
Ir-
Ru-based
organometallic
photocatalysts
have
attracted
significant
interest
because
their
high
stability,
high-energy
triplet
state,
strong
visible-light
absorption,
long
luminescence
lifetime,
amenability
to
ligand
modification.
This
review
highlights
recent
progress
photocatalyst-promoted
synthesis
modification
carbohydrates
under
photoirradiation,
well
related
benefits
drawbacks.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(45)
Published: July 25, 2024
Abstract
C−H
bond
functionalization
involving
C
,
‐palladacycle
intermediates
provides
a
unique
platform
for
developing
novel
reactions.
However,
the
vast
majority
of
studies
have
been
limited
to
transformations
(aryl),
‐palladacycles.
In
sharp
contrast,
catalytic
reactions
(alkyl),
(alkyl)‐palladacycles
rarely
reported.
Herein,
we
disclose
an
unprecedented
cascade
C(sp
3
)−H
annulation
(alkyl)‐palladacycles.
this
protocol,
alkene‐tethered
cycloalkenyl
bromides
undergo
intramolecular
Heck/C(sp
activation
generate
(alkyl)‐palladacycles,
which
can
be
captured
by
α
‐bromoacrylic
acids
afford
tricyclic
fused
pyridinediones.
addition,
strategy
also
applied
indole‐tethered
construct
pentacyclic
pyridinediones
via
suquential
Heck
dearomatization/C(sp
activation/decarboxylative
cyclization.
Notably,
removal
in
reaction
build
interesting
skeleton
containing
four‐membered
ring.
Preliminary
mechanistic
experiments
indicate
that
five‐membered
serve
as
key
intermediates.
Meanwhile,
density
functional
theory
(DFT)
calculations
provided
insights
into
pathway.
Comptes Rendus Chimie,
Journal Year:
2025,
Volume and Issue:
28(G1), P. 199 - 213
Published: Feb. 27, 2025
The
importance
and
ubiquity
of
glycosides
in
both
compounds
interest
biological
processes
make
these
biomolecules
an
interesting
topic
study.
development
unnatural
analogues
is
equally
compelling
has
already
led
to
the
production
several
marketed
drugs.
discovery
novel
carbohydrates
thus
a
field
interest.
In
order
open
up
this
chemical
space,
it
necessary
set
new
efficient
synthetic
methods,
which
lead
diverse
glycosides,
some
could
become
beneficial
compounds.
This
account
deals
with
benefits
presented
by
metal-catalyzed
reactions,
especially
cross-couplings
C–H
functionalization,
enable
glycoside
diversity.
L'importance
et
l'omniprésence
des
dans
composés
d'intérêt
les
processus
biologiques
font
de
ces
biomolécules
motifs
intéressants.
Le
développement
d'analogues
non
naturels
est
d'importance
déjà
permis
d'accéder
nombreux
médicaments.
La
découverte
nouveaux
donc
un
domaine
d'intérêt.
Afin
d'ouvrir
l'espace
chimique,
il
nécessaire
mettre
au
point
nouvelles
méthodes
synthèse
efficaces
permettant
à
une
diversité
dont
certains
pourraient
se
révéler
être
chefs
file.
Cet
article
rapporte
le
bénéfice
réactions
métallo-catalysées,
en
particulier
couplages
croisés
la
fonctionnalisation
C–H,
pour
accéder
glycosides.
Nanotechnology,
Journal Year:
2025,
Volume and Issue:
36(18), P. 185202 - 185202
Published: March 28, 2025
Abstract
The
optical
response
manipulation
of
two-dimensional
materials
is
crucial
for
designing
and
optimizing
high-performance
optoelectronic
devices.
Previously,
modulation
in
semiconductors
primarily
relied
on
adjusting
carrier
density
through
excitation
or
charge
injection
using
the
energy
band-filling
effect.
Recently,
twist
angle
has
been
found
to
tune
properties
van
der
Waals
structure,
but
its
impact
transient
remains
unexplored.
Herein,
we
demonstrate
that
can
effectively
regulate
behaviors
by
tracing
evolution
responses
twisted
bilayer
WS
2
from
0°
60°.
Both
Raman
PL
spectra
consistently
show
bilayers
are
highly
dependent
angle.
Exciton
behavior
phonon
modes
exhibit
similarity
at
angles
near
60°,
significantly
change
as
approaches
30°.
Moreover,
was
carefully
investigated
a
femtosecond
pump-probe
technique.
results
reveal
significant
decrease
thermalization/relaxation
time
exciton
formation/recombination
with
∼31.0°,
compared
∼2.9°
∼58.9°,
which
be
attributed
accumulation
intralayer
carriers
due
weakened
interlayer
coupling.
These
modulate
2D
materials.
Our
study
elucidates
dynamic
provides
new
insights
future
photonic
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(22), P. 4711 - 4715
Published: May 29, 2024
The
Catellani
reaction
offers
an
opportunity
to
address
multiple
chemical
bonds
in
a
single
pot.
However,
it
is
still
quite
challenge
construct
fully
substituted
olefins
via
this
strategy,
especially
electron-rich,
unstable,
and
highly
functionalized
glycals.
Herein
we
report
the
first
palladium-catalyzed
for
direct
preparation
of
1,2-disubstituted
C-aryl
glycosides
from
easily
available
2-iodoglycals,
bromoaryl,
alkene/alkyne
substrates.
This
transformation
exhibits
wide
substrate
scope,
accommodating
diverse
functional
groups
intricate
molecular
frameworks.
innovative
reactivity
efficient
pathway
valuable
carbohydrate
analogues
building
blocks,
facilitating
novel
strategic
bond
disconnections
broadening
landscape
palladium
catalysis.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(16), P. 11502 - 11512
Published: Aug. 2, 2024
The
stereo-
and
regioselective
formation
of
chiral
molecules
is
an
interesting
important
topic
in
organic
synthesis
due
to
its
wide
applicability
intricacy
during
synthesis.
Herein,
we
disclose
a
method
for
the
selective
functionalization
glycal
dienes
synthesizing
different
glycosides
branched
sugars
regioselectively.
methodology
broad
regarding
substrate
scope
which
various
nucleophiles
glycals
were
explored.
Furthermore,
delve
into
converting
synthesized
products
naphthalene-fused
pyran
derivatives,
achieved
through
4
+
2
cycloaddition
followed
by
aromatization.
Additionally,
conducted
density
functional
theory
studies
gain
insight
when
employed.
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
42(23), P. 3029 - 3034
Published: Aug. 21, 2024
Comprehensive
Summary
A
highly
stereoselective
nickel‐catalyzed
cross‐electrophile
coupling
of
readily
accessible,
novel,
stable
oxygen‐based
glycosyl
radical
precursors,
specifically
1,2‐glycosyl
orthoesters,
is
developed.
This
approach
offers
an
effective
pathway
to
synthesize
diverse
C
‐vinyl
glycosides,
characterized
by
good
yields,
excellent
stereoselectivity,
mild
reaction
conditions,
a
broad
substrate
scope,
and
versatile
transformations
the
resulting
products.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(45)
Published: July 25, 2024
Abstract
C−H
bond
functionalization
involving
C
,
‐palladacycle
intermediates
provides
a
unique
platform
for
developing
novel
reactions.
However,
the
vast
majority
of
studies
have
been
limited
to
transformations
(aryl),
‐palladacycles.
In
sharp
contrast,
catalytic
reactions
(alkyl),
(alkyl)‐palladacycles
rarely
reported.
Herein,
we
disclose
an
unprecedented
cascade
C(sp
3
)−H
annulation
(alkyl)‐palladacycles.
this
protocol,
alkene‐tethered
cycloalkenyl
bromides
undergo
intramolecular
Heck/C(sp
activation
generate
(alkyl)‐palladacycles,
which
can
be
captured
by
α
‐bromoacrylic
acids
afford
tricyclic
fused
pyridinediones.
addition,
strategy
also
applied
indole‐tethered
construct
pentacyclic
pyridinediones
via
suquential
Heck
dearomatization/C(sp
activation/decarboxylative
cyclization.
Notably,
removal
in
reaction
build
interesting
skeleton
containing
four‐membered
ring.
Preliminary
mechanistic
experiments
indicate
that
five‐membered
serve
as
key
intermediates.
Meanwhile,
density
functional
theory
(DFT)
calculations
provided
insights
into
pathway.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Nov. 23, 2024
Site-specific
modification
of
glycosides
to
enhance
or
alter
the
physiological
properties
parent
molecule
has
become
a
highly
attractive
strategy
in
drug
development.
However,
creating
glycoside
building
blocks
with
multiple
diversifiable
positions
from
readily
available
sugar
precursors
remains
challenging
task.
Herein,
we
present
regio-
and
stereoselective
nickel-catalyzed
carboboration
glycals,
which
offers
platform
for
generating
diversity
diverse
C1
C2
potential.
Specially,
integration
modifiable
boronate
group
at
position
markedly
amplifies
versatility
this
approach,
furnishing
universal
method
swiftly
rare
sugars
C2-site
modifications
through
expedited
downstream
transformations.
This
demonstrates
broad
substrate
scope
tolerates
various
functional
groups
complex
natural
molecular
architectures.
Moreover,
illustrate
synthetic
potential
synthesis
array
analogs
both
products
pharmaceuticals.
Creating
authors
