Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158678 - 158678
Published: Dec. 1, 2024
Language: Английский
Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: 1345, P. 343748 - 343748
Published: Jan. 30, 2025
Language: Английский
Citations
1
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 99 - 99
Published: Jan. 15, 2025
As a structural and catalytic cofactor, copper is involved in many biological pathways required for the biochemistry of all living organisms. However, excess intracellular can induce cell death due to its potential catalyze generation reactive oxygen species, thus homeostasis strictly regulated. And deficiency or accumulation connected with various pathological conditions. Since success platinum-based compounds clinical treatment types neoplasias, metal-based drugs have shown encouraging perspectives drug development. Compared platinum, an essential trace element that may better prospects development than platinum. Recently, therapeutic role copper-induced autophagy chronic diseases such as Parkinson’s, Wilson’s, cardiovascular disease has already been demonstrated. In brief, ions, numerous complexes, copper-based nano-preparations could autophagy, lysosome-dependent process plays important human diseases. this review, we not only focus on current advances elucidating mechanisms compounds/preparations regulation but also outline association between
Language: Английский
Citations
0
Talanta, Journal Year: 2025, Volume and Issue: unknown, P. 127669 - 127669
Published: Jan. 1, 2025
Language: Английский
Citations
0
Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: unknown, P. 106041 - 106041
Published: Feb. 1, 2025
Language: Английский
Citations
0
Small, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 25, 2025
Abstract α‐Synuclein (α‐Syn) amyloidogenesis is considered a promising diagnostic marker and therapeutic target for Parkinson's disease (PD). Simultaneously visualizing mitigating α‐Syn are essential future PD theranostics, yet they continue to pose an insurmountable challenge. This study have herein developed nanobody‐decorated polydiacetylene approach straightforward solution. Grafting α‐Syn61‐95 segment into the third complementary determining region of parent nanobody generates engineered X30 that can bind with prevent its through homotypic interaction. It next use decorate poly(deca‐4,6‐diynedioic acid) (PDDA), ultrastrong alkyne Raman signal (2120 cm −1 ) in cellular silent region, create targeting probe PX30. The binding affinity between be further boosted over 150 times attributed rigidity PDDA backbone multivalent effect. Therefore, PX30 not only enables real‐time visualization high signal‐to‐noise ratio living zebrafish, but also alleviates amyloidogenesis‐mediated damage zebrafish embryos by effectively inhibiting at low stoichiometric concentrations scavenging pathologic reactive oxygen species.
Language: Английский
Citations
0
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Inducing programmed cell death is an efficient strategy for cancer treatments, and a deep understanding of the molecular mechanisms underlying pathways significance rational design anticancer drugs. Herein, propiolamide-mediated crosstalk between ferroptosis apoptosis investigated. In situ monitoring reactive oxygen species (ROS) formation structural changes propiolamide compounds achieved by Raman spectroscopy. The propiolamides in inducing monooxygenase-mediated ROS generation inhibiting GPX4 activities are revealed. Furthermore, pro-ferroptotic pro-apoptotic roles containing terminal alkynes verified. This study provides label-free enzyme-drug interactions their dynamics. It first attempt to basis through two important enzymes death. paves way designing novel drugs that capable triggering synergistic contribution multiple forms efficacy.
Language: Английский
Citations
0
Journal of Raman Spectroscopy, Journal Year: 2025, Volume and Issue: unknown
Published: March 10, 2025
ABSTRACT The inherent benefits of Raman spectroscopy make it a suitable tool for the analysis complex biological objects. Detection and imaging mammalian cells is one its development areas. Plasmonic tags endowed with alkyne reporter intended bioimaging by surface‐enhanced scattering in silent region are presented. Gold nanorods covalently conjugated 4‐aminotolane were obtained using dithiobis (succinimidyl propionate) characterized UV–Vis absorbance, transmission electron microscopy, dynamic light scattering. Verification surface amide bonds formation was performed attenuated total reflectance X‐ray photoelectron spectroscopy. Surface‐enhanced spectra registered various media compared feedback from similar system through non‐specific adsorption on gold nanorods. Cytotoxicity itself conjugates verified HeLa cell line. Spectral mapping scanning microscopy revealed localized intracellular accumulation tags. challenge associated reduced area due to aggregates inside pointed out.
Language: Английский
Citations
0
Nature Reviews Methods Primers, Journal Year: 2025, Volume and Issue: 5(1)
Published: March 27, 2025
Language: Английский
Citations
0
Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114677 - 114677
Published: April 1, 2025
Language: Английский
Citations
0
ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 30, 2025
Language: Английский
Citations
0