Structural connectivity matures along a sensorimotor-association connectional axis in youth DOI Creative Commons
Xiaoyu Xu, Hang Yang, Jing Cong

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 17, 2024

Childhood and adolescence are associated with protracted developmental remodeling of cortico-cortical structural connectivity. However, how heterochronous development in white matter connectivity spatially temporally unfolds across the macroscale human connectome remains unknown. Leveraging non-invasive diffusion MRI data from both cross-sectional (N = 590) longitudinal (baseline: N 3,949; two-year follow-up: 3,155) datasets, we found that diverges along a pre-defined sensorimotor-association (S-A) connectional axis ages 8.1 to 21.9 years. Specifically, observed continuum profiles spans an early childhood increase strength sensorimotor-sensorimotor connections late adolescent association-association strength. The S-A also captured spatial variations associations between higher-order cognition general psychopathology. Together, our findings reveal hierarchical connectome.

Language: Английский

Functional connectivity development along the sensorimotor-association axis enhances the cortical hierarchy DOI Creative Commons
Audrey Luo, Valerie J. Sydnor, Adam Pines

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 25, 2024

Abstract Human cortical maturation has been posited to be organized along the sensorimotor-association axis, a hierarchical axis of brain organization that spans from unimodal sensorimotor cortices transmodal association cortices. Here, we investigate hypothesis development functional connectivity during childhood through adolescence conforms hierarchy defined by axis. We tested this pre-registered in four large-scale, independent datasets (total n = 3355; ages 5–23 years): Philadelphia Neurodevelopmental Cohort ( 1207), Nathan Kline Institute-Rockland Sample 397), Connectome Project: Development 625), and Healthy Brain Network 1126). Across datasets, systematically varied Connectivity regions increased, whereas declined, refining reinforcing hierarchy. These consistent generalizable results establish encodes dominant pattern development.

Language: Английский

Citations

19
Functional connectome through the human life span DOI Creative Commons

Lianglong Sun,

Tengda Zhao, Xinyuan Liang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 13, 2023

The lifespan growth of the functional connectome remains unknown. Here, we assemble task-free and structural magnetic resonance imaging data from 33,250 individuals aged 32 postmenstrual weeks to 80 years 132 global sites. We report critical inflection points in nonlinear curves mean variance connectome, peaking late fourth third decades life, respectively. After constructing a fine-grained, lifespan-wide suite system-level brain atlases, show distinct maturation timelines for segregation within different systems. Lifespan regional connectivity is organized along primary-to-association cortical axis. These connectome-based normative models reveal substantial individual heterogeneities networks patients with autism spectrum disorder, major depressive Alzheimer's disease. findings elucidate evolution can serve as reference quantifying variation development, aging, neuropsychiatric disorders.

Language: Английский

Citations

26
Integrating brainstem and cortical functional architectures DOI Creative Commons
Justine Y. Hansen, Simone Cauzzo, Kavita Singh

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract The brainstem is a fundamental component of the central nervous system, yet it typically excluded from in vivo human brain mapping efforts, precluding complete understanding how influences cortical function. In this study, we used high-resolution 7-Tesla functional magnetic resonance imaging to derive connectome encompassing cortex and 58 nuclei spanning midbrain, pons medulla. We identified compact set integrative hubs with widespread connectivity cerebral cortex. Patterns between manifest as neurophysiological oscillatory rhythms, patterns cognitive specialization unimodal–transmodal hierarchy. This persistent alignment topographies shaped by spatial arrangement multiple neurotransmitter receptors transporters. replicated all findings using 3-Tesla data same participants. Collectively, work demonstrates that organizational features activity can be traced back brainstem.

Language: Английский

Citations

10
Human lifespan changes in the brain’s functional connectome DOI

Lianglong Sun,

Tengda Zhao, Xinyuan Liang

et al.

Nature Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Language: Английский

Citations

2
Morphometric brain organization across the human lifespan reveals increased dispersion linked to cognitive performance DOI Creative Commons
Jiao Li, Chao Zhang, Yao Meng

et al.

PLoS Biology, Journal Year: 2024, Volume and Issue: 22(6), P. e3002647 - e3002647

Published: June 20, 2024

The human brain is organized as segregation and integration units follows complex developmental trajectories throughout life. cortical manifold provides a new means of studying the brain’s organization in multidimensional connectivity gradient space. However, how morphometric changes across lifespan remains unclear. Here, leveraging structural magnetic resonance imaging scans from 1,790 healthy individuals aged 8 to 89 years, we investigated age-related global, within- between-network dispersions reveal networks 3D manifolds based on similarity network (MSN), combining multiple features conceptualized “fingerprint” an individual’s brain. Developmental global dispersion unfolded along patterns molecular organization, such acetylcholine receptor. Communities were increasingly dispersed with age, reflecting more disassortative profiles within community. Increasing within-network primary motor association cortices mediated influence age cognitive flexibility executive functions. We also found that secondary sensory decreasingly rest during aging, possibly indicating shift extreme central position manifolds. Together, our results MSN perspective space, providing insights into brain, well performance.

Language: Английский

Citations

7
Functional network modules overlap and are linked to interindividual connectome differences during human brain development DOI Creative Commons
Tianyuan Lei, Xuhong Liao, Xinyuan Liang

et al.

PLoS Biology, Journal Year: 2024, Volume and Issue: 22(9), P. e3002653 - e3002653

Published: Sept. 18, 2024

The modular structure of functional connectomes in the human brain undergoes substantial reorganization during development. However, previous studies have implicitly assumed that each region participates one single module, ignoring potential spatial overlap between modules. How overlapping modules develop and whether this development is related to gray white matter features remain unknown. Using longitudinal multimodal structural, functional, diffusion MRI data from 305 children (aged 6 14 years), we investigated maturation networks further revealed their structural associations. An edge-centric network model was used identify modules, nodal module affiliations quantified using entropy measure. We showed a regionally heterogeneous topography extent nodes children, with higher (i.e., more involvement) ventral attention, somatomotor, subcortical regions lower less visual default-mode regions. developed linear, spatially dissociable manner, decreased dorsomedial prefrontal cortex, putamen increased parietal lobules lateral cortex. patterns captured individual maturity as characterized by chronological age were predicted integrating morphology microstructural properties. Our findings highlight substrates, thereby advancing our understanding principles connectome

Language: Английский

Citations

4
Integrating brainstem and cortical functional architectures DOI Creative Commons
Justine Y. Hansen, Simone Cauzzo, Kavita Singh

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 26, 2023

The brainstem is a fundamental component of the central nervous system yet it typically excluded from

Language: Английский

Citations

9
The connecting brain in context: How adolescent plasticity supports experiential learning and development DOI Creative Commons
Amanda E. Baker, Adriana Galván, Andrew J. Fuligni

et al.

Developmental Cognitive Neuroscience, Journal Year: 2024, Volume and Issue: 71, P. 101486 - 101486

Published: Nov. 28, 2024

Language: Английский

Citations

3
Role of Sex in Shaping Brain Network Organization During Reading in Developmental Dyslexia DOI Creative Commons

Tihomir Taskov,

Juliana Dushanova

Children, Journal Year: 2025, Volume and Issue: 12(2), P. 207 - 207

Published: Feb. 10, 2025

Background/Methods: The influence of sex on brain organization was investigated in functional reading networks 8-year-old children, those typically developing and with developmental dyslexia (DD), utilizing the minimum spanning tree model. Results: word task revealed subtle differences connectivity highlighted even small individual variations characteristics, particularly among boys DD. In girls, significantly stronger connections core hubs were identified within between motor, parietal, visual posterior regions both hemispheres, θ (dyslexics) δ (normolexics) frequency bands. contrast, showed a more diffuse pattern, predominantly left hemisphere, encompassing anterior heteromodal sensorimotor networks. Girls exhibited greater network complexity (bigger leaf fraction, kappa, hierarchy), bands, while DD increased efficiency, except for γ2 band (smaller diameter bigger fraction). Therefore, gender-specific may affect development dyslexia. While development, its impact frontoparietal children is relatively limited. Significant observed only subset primarily higher (β2-γ2) Conclusions: Interindividual evident DD, impacting association Different rates cortical maturation sexes during childhood contribute to associated disruptions fundamental like network.

Language: Английский

Citations

0
Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health DOI Creative Commons
Golia Shafiei, Nathália Bianchini Esper, Max Hoffmann

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Major mental disorders are increasingly understood as of brain development. Large and heterogeneous samples required to define generalizable links between development psychopathology. To this end, we introduce the Reproducible Brain Charts (RBC), an open data resource that integrates from 5 large studies in youth three continents ( N =6,346; 45% Female). Confirmatory bifactor models were used create harmonized psychiatric phenotypes capture major dimensions Following rigorous quality assurance, neuroimaging carefully curated processed using consistent pipelines a reproducible manner with DataLad, Configurable Pipeline for Analysis Connectomes (C-PAC), FreeSurfer. Initial analyses RBC emphasize benefit careful assurance harmonization delineating developmental effects associations Critically, all - including phenotypes, unprocessed images, fully imaging derivatives openly shared without use agreement via International Neuroimaging Data-sharing Initiative. Together, facilitates large-scale, reproducible, research neuroscience.

Language: Английский

Citations

0