Comprehensive Assessment of Cannabidiol and HU308 in Acute and Chronic Colitis Models: Efficacy, Safety, and Mechanistic Innovations

Cells, Journal Year: 2024, Volume and Issue: 13(23), P. 2013 - 2013

Published: Dec. 5, 2024

Cannabinoids are emerging as promising treatments for inflammatory diseases such ulcerative colitis. Specifically, cannabinoid 2 (CB2) receptors, which upregulated during inflammation, have been distinctively linked to anti-inflammatory and analgesic effects. HU308, a synthetic developed activate CB2 receptors selectively, aims minimize unwanted off-target side This study evaluated the effectiveness of both cannabidiol (CBD) HU308 in mouse models dextran sodium sulphate (DSS)-induced colitis, mimic acute chronic phases Mice were treated with DSS drinking water (four percent model one two model) induce indicated by increased disease activity index (DAI) scores markers. Treatment 60 mg/kg CBD, but not lower doses, significantly reduced colitis symptoms, cytokine levels, MPO activity, while also normalizing glucagon-like peptide-1 (GLP-1) levels. showed comparable efficacy high-dose CBD (60 mg/kg) at much dose (2.5 mg/kg), without observable toxicity. effectively normalized DAI scores, colon ammonia GLP-1 expression models. These results suggest that However, demonstrates enhanced therapeutic potential achieving similar outcomes fraction required reducing risk The ability modulate GLP-1, biomarker gut endocrine function, further underscores its promise novel treatment option.

Language: Английский

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Compound (E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one downregulation of Galectin-3 ameliorates Aβ pathogenesis-induced neuroinflammation in 5 × FAD mice

Life Sciences, Journal Year: 2024, Volume and Issue: 357, P. 123085 - 123085

Published: Oct. 1, 2024

Language: Английский

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Xanthohumol Protects Against Neuronal Excitotoxicity and Mitochondrial Dysfunction in APP/PS1 Mice: An Omics-Based Study

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3754 - 3754

Published: Oct. 31, 2024

: Neuronal excitotoxicity and metabolic decline, which begin in the early stages of Alzheimer's disease (AD), pose challenges for effective amelioration. Our previous work suggested that natural compound xanthohumol, most abundant prenylated flavonoid hops, prevents memory deficits APP/PS1 mice; however, underlying mechanisms remain unclear.

Language: Английский

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Quantitative Data Analysis of Amino Acids in Serum Samples Using Surface Assisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS)

Published: Nov. 22, 2024

Language: Английский

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