Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158338 - 158338
Published: Dec. 1, 2024
Language: Английский
MedComm, Journal Year: 2024, Volume and Issue: 5(11)
Published: Nov. 1, 2024
Abstract Small molecule drugs are increasingly emerging as innovative and effective treatments for various diseases, with mRNA therapeutics being a notable representative. The success of COVID‐19 vaccines has underscored the transformative potential in RNA therapeutics. Within family, there is another unique type known circRNA. This single‐stranded closed‐loop offers advantages over mRNA, including enhanced stability prolonged protein expression, which may significantly impact therapeutic strategies. Furthermore, circRNA plays pivotal role pathogenesis such cancers, autoimmune disorders, cardiovascular making it promising clinical intervention target. Despite these benefits, application settings remains underexplored. review provides comprehensive overview current state synthetic therapeutics, focusing on its synthesis, optimization, delivery, diverse applications. It also addresses challenges impeding advancement from bench to bedside. By summarizing aspects, aims equip researchers insights into ongoing developments future directions Highlighting both progress existing gaps research, this valuable perspectives advancing field guiding investigations.
Language: Английский
Citations
9
Journal of Materials Chemistry A, Journal Year: 2024, Volume and Issue: 12(35), P. 23125 - 23146
Published: Jan. 1, 2024
The present review gives an overview of the different state-of-the-art X-ray techniques employed for characterisation photoelectrocatalytic systems, focusing on possibilities studied techniques, cell designs and relevant results.
Language: Английский
Citations
7
Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(11)
Published: Oct. 25, 2024
Lactylation, a recently identified form of protein post-translational modification (PTM), has emerged as key player in cancer biology. The Warburg effect, hallmark tumour metabolism, underscores the significance lactylation progression. By regulating gene transcription and function, facilitates metabolic reprogramming, enabling tumours to adapt nutrient limitations sustain rapid growth. Over past decade, extensive research revealed intricate regulatory network underlying tumours. Large-scale sequencing machine learning have confirmed widespread occurrence sites across proteome. Targeting enzymes or pathways demonstrated promising anti-tumour effects, highlighting therapeutic potential this modification. This review comprehensively explores mechanisms cells microenvironment. We expound on application advanced omics technologies for target identification data modelling within field. Additionally, we summarise existing anti-lactylation drugs discuss their clinical implications. providing comprehensive overview recent advancements, aims stimulate innovative accelerate translation lactylation-based therapies into practice. KEY POINTS: Lactylation significantly influences metabolism regulation, contributing Advanced reveal shows promise enhancing drug efficacy overcoming chemotherapy resistance. outlines implications future directions oncology.
Language: Английский
Citations
5
MedComm, Journal Year: 2025, Volume and Issue: 6(2)
Published: Feb. 1, 2025
Abstract Circular RNA (circRNA), a subtype of noncoding RNA, has emerged as significant focus in research due to its distinctive covalently closed loop structure. CircRNAs play pivotal roles diverse physiological and pathological processes, functioning through mechanisms such miRNAs or proteins sponging, regulation splicing gene expression, serving translation templates, particularly the context various cancers. The hallmarks cancer comprise functional capabilities acquired during carcinogenesis tumor progression, providing conceptual framework that elucidates nature malignant transformation. Although numerous studies have elucidated role circRNAs cancers, their functions development chemoradiotherapy resistance remain unexplored clinical applications circRNA‐based translational therapeutics are still infancy. This review provides comprehensive overview circRNAs, covering biogenesis, unique characteristics, functions, turnover mechanisms. We also summarize involvement relevance biomarkers therapeutic targets, especially thyroid (TC). Considering potential fascination therapeutics, “Ying‐Yang” dynamic regulations TC warrant vastly dedicated investigations.
Language: Английский
Citations
0
Chemical Communications, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Extracellular vesicles have been deemed as potential drug carriers for treatment of various diseases. Recent advances summarized, including the sources, delivery function, extraction and cargo-loading technology extracellular vesicles.
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 8, 2025
Colorectal cancer (CRC) is one of the most common cancers worldwide and liver metastasis leading reason for its mortality. Circular RNAs (circRNAs) are conclusively associated with progression various cancers, rendering exploration specific mechanisms in colorectal metastasis(CRLM) highly valuable. Combined GEO (Gene Expression Omnibus) databases clinical data our center, we found that high expression circSATB1 closely related to CRLM. Functionally, could significantly promote metastatic ability CRC cells vitro vivo. Mechanistically, facilitated RNF25-mediated ubiquitylation degradation FKBP8, releasing inhibitory effects on mTOR signaling. In this process, acted as a scaffold RNF25-FKBP8 complexes. Additionally, be packaged exosomes secreted from primary tumors into plasma. conclusion, study uncovered new acts potent promoter CRLM offers novel insights precision therapeutic strategies
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 17, 2025
Abstract Electrotherapy has shown considerable potential in treating chronic wounds, but conventional approaches relying on bulky external power supplies and mechanical force are limited their clinical utility. This study introduces an autonomous, moisture‐driven flexible electrogenerative dressing (AMFED) that overcomes these limitations. The AMFED integrates a moist‐electric generator (MEG), antibacterial hydrogel dressing, concentric molybdenum (Mo) electrodes to provide self‐sustaining electrical supply potent activity against Staphylococcus aureus Escherichia coli . MEG harnesses chemical energy from moisture produce stable direct current of 0.61 V without input, delivering this therapeutic stimulation the wound site through Mo electrodes. facilitates macrophage polarization toward reparative M2 phenotype regulates inflammatory cytokines. Moreover, vivo studies suggest group significantly enhances healing, with approximate 41% acceleration compared control group. Using diabetic mouse model, demonstrates its effectiveness promoting nerve regulation, epithelial migration, vasculogenesis. These findings present novel efficient platform for accelerating healing.
Language: Английский
Citations
0
Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)
Published: Feb. 22, 2025
Language: Английский
Citations
0
ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 6, 2025
Language: Английский
Citations
0
Russian Chemical Reviews, Journal Year: 2024, Volume and Issue: 93(11), P. RCR5150 - RCR5150
Published: Oct. 30, 2024
Diabetes and its complications derived are among serious global health concerns that critically deteriorate the quality of life patients and, in some cases, result lethal outcome. Herein, general information on pathogenesis, factors aggravating course disease drugs used for treatment two types diabetes briefly discussed. The aim review is to introduce supramolecular strategies currently being developed mellitus present a very effective alternative chemical synthesis, allowing fabrication nanocontainers with switchable characteristics meet criteria green chemistry. Particular attention paid organic (amphiphilic polymeric) formulations, including those natural origin, due their biocompatibility, low toxicity, bioavailability. advantages limitations different nanosystems discussed, emphasis adaptivity noninvasive administration routes.<br>The bibliography includes 378 references.
Language: Английский
Citations
3